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Atypical Antipsychotic

olanzapine for Insulin Resistance

Phase < 1
Waitlist Available
Research Sponsored by Wayne State University
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be between 18 and 65 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up baseline (day 1) to endpoint of intervention (day 7)
Awards & highlights

Study Summary

This trial will study how atypical antipsychotics cause insulin resistance by looking at genetic and protein changes in people taking the medication.

Eligible Conditions
  • Insulin Resistance
  • Adverse Effects

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~baseline (day 1) to endpoint of intervention (day 7)
This trial's timeline: 3 weeks for screening, Varies for treatment, and baseline (day 1) to endpoint of intervention (day 7) for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Change in DNA methylation
Secondary outcome measures
Change in protein activity
Change in protein levels

Side effects data

From 2013 Phase 4 trial • 450 Patients • NCT01157351
12%
Insomnia
9%
Headache
8%
Dry Mouth
8%
Sedation
8%
Anxiety
8%
Depression
8%
Akathisia
7%
Weight Increased
7%
Somnolence
6%
Laceration
6%
Toothache
6%
Nasopharyngitis
5%
Schizophrenia
5%
Upper Respiratory Tract Infection
5%
Dizziness
5%
Suicidal Ideation
4%
Hypertension
4%
Constipation
4%
Increased Appetite
4%
Back Pain
4%
Pain in Extremity
3%
Psychotic Disorder
3%
Diarrhoea
3%
Joint Sprain
3%
Cough
3%
Nausea
3%
Fatigue
3%
Irritability
3%
Hallucination, Auditory
2%
Hyperprolactinaemia
2%
Abdominal Discomfort
2%
Abnormal Weight Gain
2%
Vomiting
2%
Bronchitis
2%
Influenza
2%
Dyskinesia
2%
Dystonia
2%
Agitation
2%
Schizophrenia, Paranoid Type
2%
Extrapyramidal Disorder
2%
Pain
1%
Homicidal Ideation
1%
Acute Psychosis
1%
Dyspepsia
1%
Arthralgia
1%
Tremor
1%
Libido Decreased
1%
Suicide Attempt
1%
Renal Failure Acute
1%
Blood Prolactin Increased
100%
80%
60%
40%
20%
0%
Study treatment Arm
Oral Antipsychotics
Paliperidone Palmitate

Trial Design

2Treatment groups
Experimental Treatment
Placebo Group
Group I: olanzapineExperimental Treatment1 Intervention
Atypical antipsychotic
Group II: placeboPlacebo Group1 Intervention
Placebo comparator
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
olanzapine
2005
Completed Phase 4
~5220

Find a Location

Who is running the clinical trial?

Wayne State UniversityLead Sponsor
307 Previous Clinical Trials
108,433 Total Patients Enrolled
1 Trials studying Insulin Resistance

Media Library

Olanzapine (Atypical Antipsychotic) Clinical Trial Eligibility Overview. Trial Name: NCT02708394 — Phase < 1
Insulin Resistance Research Study Groups: placebo, olanzapine
Insulin Resistance Clinical Trial 2023: Olanzapine Highlights & Side Effects. Trial Name: NCT02708394 — Phase < 1
Olanzapine (Atypical Antipsychotic) 2023 Treatment Timeline for Medical Study. Trial Name: NCT02708394 — Phase < 1

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is the current patient count for this clinical experiment?

"This research is currently not looking for enrollees. It was initially posted on February 1, 2017 and updated as recently as July 11, 2022. However, those seeking medical trials may wish to consider the 163 active studies of insulin resistance or the 19 olanzapine related experiments that are now accepting participants."

Answered by AI

Does this experiment accept participants who are below the age of 65?

"Patients aged between 21 and 45 are eligible to participate in this research."

Answered by AI

Are there any historical examples of research involving olanzapine?

"Presently, 19 active studies investigating olanzapine are ongoing with 4 at Phase 3. Though the majority of research is conducted in Kansas City, Missouri, a total of 706 medical centres across the world have trials available for this drug."

Answered by AI

Can I join the participants of this clinical research experiment?

"To qualify for this drug trial, a patient must be between 21 and 45 years old with insulin resistance. The total capacity of the study is 76 individuals."

Answered by AI

In what diseases is olanzapine prescribed frequently?

"Olanzapine is the go-to medication for treating delusional parasitosis and has also been found to help reduce acute agitation, delirium, as well as unipolar depression."

Answered by AI

Are new participants still being welcomed into this experiment?

"The clinicaltrials.gov database confirms that this medical trial is not accepting applicants at present, despite its initial launch in February 2017 and latest update on July 11th 2022. However, there are 182 other studies actively seeking participants now."

Answered by AI

Is this particular medical experiment a pioneering endeavor?

"Presently, 19 clinical trials exist for olanzapine in 7 nations and 401 cities. The first of these studies was initiated by Eli Lilly and Company in 2007 with 20 participants, eventually leading to N/A drug approval. Over the past 14 years since then, 2887 further tests have been held."

Answered by AI
Recent research and studies
clinicaltrials.govStudy
Molecular Mechanisms of Antipsychotic-induced Insulin Resistance
Kyle Jon Burghardt, Pharm.D. 2017. "Molecular Mechanisms of Antipsychotic-induced Insulin Resistance". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT02708394.
~4 spots leftby Apr 2025
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