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Rho Kinase Inhibitor

Netarsudil Eye Drops for Fuchs' Dystrophy

Q: Are there any opportunities for volunteers to join this research?

<p>Affirmative. According to clinicaltrials.gov, this scientific investigation is currently looking for participants; it was published on 3/28/2021 and last modified on 8/23/2022. 25 individuals are required at one research facility.</p>

Q: How many participants have been recruited for this research endeavor?

<p>Affirmative. As per information published on clinicaltrials.gov, this medical trial is actively in search of participants and was posted to the site on March 28th 2021 with a most recent update from August 23rd 2022. It seeks 25 patients from one location for enrolment.</p>

Phase < 1

Waitlist Available

Led By Emma Davies, MD

Research Sponsored by Massachusetts Eye and Ear Infirmary

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Be older than 18 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up measured at post-operative month one visit and then every 2 months for 1 year

Awards & highlights

Study Summary

This trial will look at whether a certain medication can improve healing time and cell counts after a specific eye surgery.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ measured at post-operative month one visit and then every 2 months for 1 year

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~measured at post-operative month one visit and then every 2 months for 1 year

This trial's timeline: 3 weeks for screening, Varies for treatment, and measured at post-operative month one visit and then every 2 months for 1 year for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Change in central corneal pachymetry over time

Change in endothelial cell count over time

Side effects data

From 2021 Phase 2 trial • 40 Patients • NCT04498169

15%

Corneal verticillata

10%

Conjunctival hypaeremia

100%

80%

60%

40%

20%

Study treatment Arm

Once Daily Netarsudil Ophthalmic Solution

Twice Daily Netarsudil Ophthalmic Solution

Trial Design

1Treatment groups

Experimental Treatment

Group I: Netarsudil useExperimental Treatment1 Intervention

Patients will receive Netarsudil eye drops to use 1 drop nightly in the operative eye after DWEK surgery until corneal clearance

Treatment

First Studied

Drug Approval Stage

How many patients have taken this drug

Netarsudil

FDA approved

Do I qualify?Apply below to find out

Find a Location

Who is running the clinical trial?

Massachusetts Eye and Ear InfirmaryLead Sponsor

106 Previous Clinical Trials

12,924 Total Patients Enrolled

Emma Davies, MDPrincipal InvestigatorMassachusetts Eye and Ear Infirmary

Sila E Bal, MD, MPHPrincipal InvestigatorMassachusetts Eye and Ear Infirmary

Media Library

Netarsudil Ophthalmic (Rho Kinase Inhibitor) Clinical Trial Eligibility Overview. Trial Name: NCT04752020 — Phase < 1

Fuchs' Dystrophy Research Study Groups: Netarsudil use

Fuchs' Dystrophy Clinical Trial 2023: Netarsudil Ophthalmic Highlights & Side Effects. Trial Name: NCT04752020 — Phase < 1

Netarsudil Ophthalmic (Rho Kinase Inhibitor) 2023 Treatment Timeline for Medical Study. Trial Name: NCT04752020 — Phase < 1

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Are there any opportunities for volunteers to join this research?

"Affirmative. According to clinicaltrials.gov, this scientific investigation is currently looking for participants; it was published on 3/28/2021 and last modified on 8/23/2022. 25 individuals are required at one research facility."

Answered by AI

How many participants have been recruited for this research endeavor?

"Affirmative. As per information published on clinicaltrials.gov, this medical trial is actively in search of participants and was posted to the site on March 28th 2021 with a most recent update from August 23rd 2022. It seeks 25 patients from one location for enrolment."

Answered by AI

Recent research and studies

clinicaltrials.govStudy

Netarsudil Use After Descemtorhexis Without Endothelial Keratoplasty

Emma C. Davies, MD 2021. "Netarsudil Use After Descemtorhexis Without Endothelial Keratoplasty". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT04752020.