← Back to Search

Upper body obesity for Obesity

Q: Do I qualify for enrollment in this experimental procedure?

To qualify for the trial, patients must have <a href="https://www.withpower.com/clinical-trials/obesity">obesity</a> and be between 18 to 65 years old. Currently, 32 participants are accepted into this research project.

Q: Does the study extend its eligibility to individuals aged 70 and above?

This research requires volunteers aged between 18 years and 65 years.

Q: Is this program currently enrolling new participants?

According to clinicaltrials.gov, this specific medical trial is no longer recruiting participants; the study was posted on December 1st 2023 and updated as recently as 7th of that same month. However, there are more than sixty additional trials actively seeking candidates at this present moment in time.

Phase < 1

Recruiting

Led By Michael Jensen, MD

Research Sponsored by Mayo Clinic

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Males and females between 18 and 65 years of age who are able to comprehend instructions, follow study procedures, willing to sign an informed consent form, and consume an isoenergetic diet eating all meals from Mayo CRTU for at least 3 days prior to study

Upper body obesity criteria for men

Timeline

Screening 3 weeks

Treatment Varies

Follow Up approx. 6 hours

Awards & highlights

Study Summary

This trial is studying why people who gain weight in their belly often don't respond to weight loss methods like those who are leaner.

Who is the study for?

This study is for men and women aged 18-65 who are overweight or obese, with a BMI of 29.0 - 40.0 kg/m2, especially those carrying extra weight around their abdomen. Participants must not have heart disease, high blood pressure that's uncontrolled by medication, be smokers, or take drugs affecting fat metabolism. They should also not be allergic to lidocaine or Niaspan.Check my eligibility

What is being tested?

The trial is investigating how niacin affects fat tissue in people with different body types, particularly focusing on adults who carry excess abdominal weight and may react differently to factors that usually 'turn off' fat cells.See study design

What are the potential side effects?

While the side effects of niacin are not detailed here, common ones include skin flushing or redness, itching or tingling sensations, digestive upset like nausea or indigestion, and increased blood sugar levels.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

Select...

I am between 18 and 65 years old, can follow instructions, and am willing to eat specific meals for 3 days before the study.

Select...

I am a man with most of my body fat around my waist.

Select...

My BMI is between 29.0 and 40.0.

Select...

I am a woman with upper body or visceral obesity.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ approx. 6 hours

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~approx. 6 hours

This trial's timeline: 3 weeks for screening, Varies for treatment, and approx. 6 hours for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Change in plasma free fatty acid (FFA) concentrations

Secondary outcome measures

pHSL/HSL response

Side effects data

From 2008 Phase 4 trial • 30 Patients • NCT00203476

50%

Flushing

10%

Loose Stools

10%

Elevated LFTs

100%

80%

60%

40%

20%

Study treatment Arm

Niacin

Colestipol

Ezetimibe

Trial Design

2Treatment groups

Experimental Treatment

Group I: Upper body obesityExperimental Treatment1 Intervention

Subjects identify with upper body obesity will receive Niacin to lean how fat cells in different regions of the body the response.

Group II: Normal weightExperimental Treatment1 Intervention

Subjects identify with normal body weight will receive Niacin to lean how fat cells in different regions of the body the response.

Treatment

First Studied

Drug Approval Stage

How many patients have taken this drug

Niacin

2008

Completed Phase 4

~1000

0 / 4Eligibility criteria met

Find a Location

Who is running the clinical trial?

Mayo ClinicLead Sponsor

3,216 Previous Clinical Trials

3,767,456 Total Patients Enrolled

85 Trials studying Obesity

14,723 Patients Enrolled for Obesity

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)NIH

2,359 Previous Clinical Trials

4,314,560 Total Patients Enrolled

447 Trials studying Obesity

588,938 Patients Enrolled for Obesity

Michael Jensen, MDPrincipal InvestigatorMayo Clinic

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Do I qualify for enrollment in this experimental procedure?

"To qualify for the trial, patients must have obesity and be between 18 to 65 years old. Currently, 32 participants are accepted into this research project."

Answered by AI

Does the study extend its eligibility to individuals aged 70 and above?

"This research requires volunteers aged between 18 years and 65 years."

Answered by AI

Is this program currently enrolling new participants?

"According to clinicaltrials.gov, this specific medical trial is no longer recruiting participants; the study was posted on December 1st 2023 and updated as recently as 7th of that same month. However, there are more than sixty additional trials actively seeking candidates at this present moment in time."

Answered by AI

Recent research and studies

clinicaltrials.govStudy

A Study of Niacin Regulation

Michael D. Jensen 2024. "A Study of Niacin Regulation". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT06175403.

All > Weight Gain > Paid Studies Minneapolis