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Chemotherapy + Bevacizumab +/- Immunotherapy for Advanced Non-Small Cell Lung Cancer
Study Summary
This trial is for never or light smokers with non-squamous non-small cell lung cancer that has spread and progressed after other treatments. It tests the addition of bevacizumab to carboplatin and paclitaxel to see if it improves survival.
Eligibility Criteria
Inclusion Criteria
You may be eligible if you check “Yes” for the criteria belowTimeline
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.Trial Design
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Who is running the clinical trial?
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- I have had a severe hypertension crisis or brain issues due to high blood pressure.I do not have any uncontrolled illnesses or infections that would affect my participation.I am willing to switch from denosumab to a bisphosphonate for the study.I am fully active or can carry out light work.I have been diagnosed with tuberculosis, whether active or inactive.I have tested positive for HIV/AIDS.I have pain from my cancer that isn't relieved by treatment.I have not received a live vaccine in the last 30 days.I completed my curative therapy over a year ago.I am on a long-term blood thinner that is not aspirin.I am willing to use birth control if I can have children.Your blood calcium levels are higher than normal.My organs and bone marrow are functioning normally.I have an autoimmune disease treated in the last year.My cancer has spread to the lining of my brain and spinal cord.The amount of protein in your urine should be very low.I haven't had any serious wounds, ulcers, or untreated fractures in the last 28 days.I have not had major surgery in the last 28 days or minor surgery in the last 7 days.I have had a bone marrow or organ transplant in the past.I haven't had chemotherapy, anti-VEGF, or immunotherapy, except for oral TKIs if I have EGFR mutation.My blood pressure is high and not well managed.Your lung lesions show clear cavities on imaging.My tumor has an EGFR mutation in exon 19 or 21, or I have never smoked.My lung cancer is advanced and not of the squamous type.I agree to use contraception since my partner can become pregnant.I have never needed steroids for lung inflammation.My lung cancer has a specific genetic change.My tumor has an EGFR mutation and I've been treated with TKIs.I do not need IV fluids, feeding tubes, or have blockages in my digestive system.I have recovered from side effects of previous treatments, except for nerve issues or hair loss.I am not currently on any experimental drugs or cancer treatments.I am older than 18 years.I have a chronic hepatitis B or C infection that is not cured.I have been diagnosed with squamous cell lung cancer.You have a condition that causes abnormal bleeding or blood clotting.I have not had severe GI bleeding in the last 3 months.I have untreated brain metastases larger than 1 cm.I have severe liver disease, with symptoms like confusion or fluid in my abdomen.I have not had a fistula or gut perforation in the last 6 months.You have air in your abdomen that can't be explained by a recent medical procedure.I have not had any blood clots in my arteries in the last 6 months.I have not had major blood vessel problems in the last 6 months.I take more than 10 mg of prednisolone or its equivalent daily.I can provide a biopsy sample for the study, or undergo a new biopsy if needed.I have not coughed up blood in the last month and my cancer hasn't invaded major blood vessels.I have at least one tumor that can be measured by CT or MRI.I have smoked more than 100 cigarettes in my life, but my tumor has an EGFR mutation.My scans show cancer has spread to the large blood vessels in my chest.I have had brain metastases treated and am not currently showing symptoms.I had cancer before, but it's been in complete remission for over 2 years and I don't need treatment now.I have been on a stable dose of blood thinners for at least 14 days.
- Group 1: Arm A
- Group 2: Arm B
- No Placebo-Only Group - All patients enrolled in this study will receive some form of active treatment.
- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Frequently Asked Questions
Has Arm A received the regulatory greenlight from the FDA?
"Arm A was assessed as a 2 on the 1 to 3 scale due to there being evidence for safety, but not yet any data demonstrating efficacy."
Is this research endeavor open to enrollees at the moment?
"Correct. Data accessible on clinicaltrials.gov verifies that this research endeavour, which began to accept applications on September 4th 2019 is actively enrolling 117 participants from 1 clinic site."
What is the anticipated size of this trial's participant pool?
"Affirmative. According to clinicaltrials.gov, this particular medical trial is currently recruiting patients who meet the criteria. The experiment was initially posted on September 4th 2019 and has been recently updated as of February 8th 2022; 117 individuals across one site are needed for data collection purposes."
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