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Niacin for Obesity

Phase < 1
Waitlist Available
Led By Michael D Jensen
Research Sponsored by Mayo Clinic
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
BMI 29-37
Weight stable
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 18 hours
Awards & highlights

Study Summary

This trial will study the effects of muscle insulin resistance on upper body obesity and Type 2 diabetes, and whether lowering free fatty acids (FFA) with an intravenous infusion of niacin affects muscle glucose uptake.

Eligible Conditions
  • Obesity
  • Type 2 Diabetes

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~18 hours
This trial's timeline: 3 weeks for screening, Varies for treatment, and 18 hours for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Difference in incorporation of 13-palmitate and D9-palmitate into intramyocellular lipid intermediates between overnight saline control study and overnight/insulin clamp niacin infusion study.
Pain management
Difference in insulin-stimulated phosphorylation of insulin-responsive signaling molecules between overnight saline control study and overnight/insulin clamp niacin infusion study.
Secondary outcome measures
Effects of niacin on adipocyte lipolysis proteins

Side effects data

From 2008 Phase 4 trial • 30 Patients • NCT00203476
50%
Flushing
10%
Loose Stools
10%
Elevated LFTs
100%
80%
60%
40%
20%
0%
Study treatment Arm
Niacin
Colestipol
Ezetimibe

Trial Design

2Treatment groups
Experimental Treatment
Placebo Group
Group I: NiacinExperimental Treatment1 Intervention
Intravenous niacin infusion
Group II: SalinePlacebo Group1 Intervention
Intravenous saline infusion
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Niacin
2008
Completed Phase 4
~970

Find a Location

Who is running the clinical trial?

Mayo ClinicLead Sponsor
3,207 Previous Clinical Trials
3,767,120 Total Patients Enrolled
84 Trials studying Obesity
14,703 Patients Enrolled for Obesity
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)NIH
2,358 Previous Clinical Trials
4,315,221 Total Patients Enrolled
446 Trials studying Obesity
588,918 Patients Enrolled for Obesity
Michael D JensenPrincipal InvestigatorMayo Clinic
1 Previous Clinical Trials
64 Total Patients Enrolled
1 Trials studying Obesity
64 Patients Enrolled for Obesity

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

For what medical treatments is Niacin commonly prescribed?

"Niacin is frequently utilized to reduce cardiovascular risk, as well as managing dyslipidemias, lipidemia and even the potential of pancreatitis."

Answered by AI

Are there vacancies in this trial for participants?

"Judging from clinicaltrials.gov, this research is currently seeking participants. The trial was initially posted on November 1st 2018 and the data has been recently revised as of April 13th 2022."

Answered by AI

Who has the prerogative to participate in this scientific experiment?

"In order to meet the eligibility requirements of this trial, applicants must have type 2 diabetes mellitus and be between 18-55 years old. This clinical research is seeking 20 volunteers in total."

Answered by AI

What is the maximum capacity for participants in this clinical trial?

"Affirmative. Clinicaltrials.gov's records demonstrate that this clinical study, initially unveiled on November 1st 2018, is currently enrolling patients. The endeavour needs to acquire 20 participants from a single location."

Answered by AI

Does the research include individuals who are more than twenty years of age?

"To be eligible for participation, participants need to have attained the age of majority and must not exceed 55 years."

Answered by AI
Recent research and studies
clinicaltrials.govStudy
Effects of Niacin on Intramyocellular Fatty Acid Trafficking in Upper Body Obesity and Type 2 Diabetes Mellitus
Michael D. Jensen 2018. "Effects of Niacin on Intramyocellular Fatty Acid Trafficking in Upper Body Obesity and Type 2 Diabetes Mellitus". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT03867500.
~1 spots leftby Jul 2024
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