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Anti-fibrinolytic agent

Topical and Intravenous TXA for Spinal Deformity

Phase < 1
Waitlist Available
Led By Firoz Miyanji, MD
Research Sponsored by University of British Columbia
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be younger than 65 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up intra-operative
Awards & highlights

Study Summary

Our study will evaluate the use of topical and intravenous (IV) Tranexamic Acid (TXA) in spine surgery. The purpose of TXA is to prevent clotting during surgery to reduce blood loss. When used intravenously, it has been shown to safe, efficacious, and effective in reducing transfusion requirements and blood loss in spine surgeries. We want to evaluate the effect of using TXA topically and intravenously to see if it further reduces blood loss in children undergoing major surgery compared to IV TXA only

Eligible Conditions
  • Spinal Deformity

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~6 week visit
This trial's timeline: 3 weeks for screening, Varies for treatment, and 6 week visit for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Volume of Blood Loss
Secondary outcome measures
Complications (reporting)

Trial Design

2Treatment groups
Experimental Treatment
Active Control
Group I: Topical and Intravenous TXAExperimental Treatment2 Interventions
Group II: Intravenous TXA onlyActive Control1 Intervention

Find a Location

Who is running the clinical trial?

University of British ColumbiaLead Sponsor
1,410 Previous Clinical Trials
1,766,411 Total Patients Enrolled
Firoz Miyanji, MDPrincipal InvestigatorClinical Assistant Professor
Brett Kilb, MdStudy ChairResident

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Recent research and studies
clinicaltrials.govStudy
Topical Tranexamic Acid in Major Paediatric Spine Deformity Surgery: A Randomized Controlled Trial
2015. "Topical Tranexamic Acid in Major Paediatric Spine Deformity Surgery: A Randomized Controlled Trial". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT02093988.
All > Major Depressive Disorder
~17 spots leftby Apr 2025
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