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Broccoli Sprout/Broccoli Seed Extract Supplement for Cancer

Phase < 1
Waitlist Available
Led By Julie E Bauman
Research Sponsored by National Cancer Institute (NCI)
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up up to 14 days post intervention
Awards & highlights

Study Summary

This trial is testing whether a broccoli supplement can help decrease toxicity in heavy smokers.

Eligible Conditions
  • Cancer
  • Tobacco-Related Cancer

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~up to 14 days post intervention
This trial's timeline: 3 weeks for screening, Varies for treatment, and up to 14 days post intervention for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Change in Urinary Excretion of the Mercapturic Acid of Benzene Following 4 Tablets Per Day of Avmacol
Change in Urinary Excretion of the Mercapturic Acid of Benzene Following 8 Tablets Per Day of Avmacol
Secondary outcome measures
Change in the NRF2 Target Gene Transcripts
Change in the Urinary Excretion of the Mercapturic Acids of Acrolein and Crotonaldehyde
Dose-response Relationship Between Avmacol Dose and Detoxification of Tobacco Carcinogens
+1 more
Other outcome measures
GSTM1 and GSTT1 Genotypes

Trial Design

2Treatment groups
Experimental Treatment
Group I: Arm II (Avmacol higher dose, Avmacol lower dose)Experimental Treatment3 Interventions
Participants receive higher dose broccoli sprout/broccoli seed extract supplement PO daily for 10-14 days. After 10-14 days, participants receive lower dose broccoli sprout/broccoli seed extract supplement PO daily for 10-14 days.
Group II: Arm I (Avmacol lower dose, Avmacol higher dose)Experimental Treatment3 Interventions
Participants receive lower dose broccoli sprout/broccoli seed extract supplement PO daily for 10-14 days. After 10-14 days, participants receive higher dose broccoli sprout/broccoli seed extract supplement PO daily for 10-14 days.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Broccoli Sprout/Broccoli Seed Extract Supplement
2018
Completed Early Phase 1
~50

Find a Location

Who is running the clinical trial?

National Cancer Institute (NCI)Lead Sponsor
13,654 Previous Clinical Trials
40,933,104 Total Patients Enrolled
Julie E BaumanPrincipal InvestigatorThe University of Arizona Medical Center-University Campus
2 Previous Clinical Trials
157 Total Patients Enrolled

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Recent research and studies
clinicaltrials.govStudy
Broccoli Sprout/Broccoli Seed Extract Supplement in Decreasing Toxicity in Heavy Smokers
2018. "Broccoli Sprout/Broccoli Seed Extract Supplement in Decreasing Toxicity in Heavy Smokers". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT03402230.
~7 spots leftby Apr 2025
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