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Tricyclic Antidepressant

Imipramine for Breast Cancer

Phase < 1
Waitlist Available
Led By Virginia G Kaklamani, MD
Research Sponsored by The University of Texas Health Science Center at San Antonio
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 30 days
Awards & highlights

Study Summary

This trial is comparing changes in biomarkers between a diagnostic core needle biopsy, surgical pathology specimen, and repeat core needle biopsy.

Eligible Conditions
  • Breast Cancer

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~30 days
This trial's timeline: 3 weeks for screening, Varies for treatment, and 30 days for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Decrease in the proliferation rate of triple negative breast cancer

Side effects data

From 2011 Phase 1 & 2 trial • 25 Patients • NCT00296725
18%
lost to follow-up
12%
rash
6%
shortness of breath
6%
irritability
100%
80%
60%
40%
20%
0%
Study treatment Arm
Fluoxetine
Imipramine

Trial Design

1Treatment groups
Experimental Treatment
Group I: ImipramineExperimental Treatment1 Intervention
Imipramine will initially be 50mg and this will be increased by 50mg every other day as tolerated to 200 mg.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Imipramine
FDA approved

Find a Location

Who is running the clinical trial?

The University of Texas Health Science Center at San AntonioLead Sponsor
452 Previous Clinical Trials
91,393 Total Patients Enrolled
14 Trials studying Breast Cancer
1,523 Patients Enrolled for Breast Cancer
Virginia G Kaklamani, MDPrincipal InvestigatorPrincipal Investigator
1 Previous Clinical Trials
21 Total Patients Enrolled

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

How many participants are enrolled in this experiment?

"This clinical trial is currently not enrolling any patients. It was initially posted on July 5th 2019 and its information was last updated on September 10th 2022. Those seeking other trials may do so, as there are presently 2602 studies searching for participants with breast cancer and 2 investigations into Imipramine in progress."

Answered by AI

Are there any openings available to participate in this trial?

"This clinical trial is no longer recruiting patients; it was initially posted on July 5th 2019 and the most recent update occured on September 10th 2022. Those looking for other studies may consider checking out 2602 trials actively enrolling participants with breast cancer or 2 Imipramine related medical trials that are currently accepting individuals."

Answered by AI

What therapeutic purposes is Imipramine typically employed for?

"Imipramine is a successful method of addressing neuropathic pain, depression, and bulimia nervosa in certain patients."

Answered by AI

Is it possible for me to join this clinical trial?

"This research project is seeking to enrol 17 individuals, ranging between 18 and 71 years old, who have been diagnosed with breast cancer. In order for potential participants to be eligible they must possess an ECOG Performance status of 0, 1 or 2; provide a complete physical examination within the last month; not suffer from any gastrointestinal issues that would compromise their absorption rate; exhibit no prior history of unrelated breast cancer and show capability when it comes to taking oral medications."

Answered by AI

Is there an age threshold for participation in this medical research?

"To be eligible for this clinical trial, patients must range from 18 to 71 years old. For younger individuals (under the age of 18), there are 75 studies and 2509 studies for senior citizens (over 65)."

Answered by AI

What precedent exists for how Imipramine has been employed in research efforts?

"At present, there are 2 clinical trials assessing the efficacy of Imipramine. None have progressed to Phase 3 yet; however, most studies take place in San Antonio with a couple elsewhere."

Answered by AI
~3 spots leftby Apr 2025