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Virus Therapy

PVSRIPO for Breast Cancer

Phase < 1
Waitlist Available
Research Sponsored by Istari Oncology, Inc.
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 10-20 days post-injection of pvsripo
Awards & highlights

Study Summary

This trial is testing a new cancer treatment called PVSRIPO in women with breast cancer. They will receive the treatment through a needle directly into their tumor. Researchers want to see if the treatment is effective and how it affects the tumor tissue.

Eligible Conditions
  • Breast Cancer

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~10-20 days post-injection of pvsripo
This trial's timeline: 3 weeks for screening, Varies for treatment, and 10-20 days post-injection of pvsripo for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Change in Tumor Infiltrating Immune Cells

Trial Design

1Treatment groups
Experimental Treatment
Group I: PVSRIPOExperimental Treatment1 Intervention
Polio vaccine booster will be administered 1 week prior to PVSRIPO injection. On the day of PVSRIPO injection (Day 0), a pre-treatment biopsy is obtained. PVSRIPO in injected into the tumor mass at a dose of 1x10^8 TCID50. On day 14, women will undergo standard-of-care surgical resection of PVSRIPO-treated tumor.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
PVSRIPO
2018
Completed Phase 1
~20

Find a Location

Who is running the clinical trial?

Duke UniversityOTHER
2,358 Previous Clinical Trials
3,420,064 Total Patients Enrolled
54 Trials studying Breast Cancer
9,951 Patients Enrolled for Breast Cancer
Istari Oncology, Inc.Lead Sponsor
12 Previous Clinical Trials
414 Total Patients Enrolled
United States Department of DefenseFED
861 Previous Clinical Trials
227,189 Total Patients Enrolled
37 Trials studying Breast Cancer
3,466 Patients Enrolled for Breast Cancer

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Recent research and studies
clinicaltrials.govStudy
Examining Bioactivity of PVSRIPO in Invasive Breast Cancer
2019. "Examining Bioactivity of PVSRIPO in Invasive Breast Cancer". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT03564782.
~1 spots leftby Apr 2025
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