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propranolol hydrochloride for Breast Cancer

Q: What medical ailments has propranolol hydrochloride been proven to alleviate?

Propranolol hydrochloride has been utilized to reduce mortality from <a href="https://www.withpower.com/clinical-trials/cardiovascular">cardiovascular</a> diseases, in addition to being beneficial for angina pectoris, myocardial infarction and obstructive hypertrophic cardiomyopathy.

Q: Are there any openings remaining for participants in this research?

According to clinicaltrials.gov, this particular investigation is no longer solicitating volunteers; it was first shared on January 21st 2014 and had its most recent update in October 3rd 2022. While the trial has been closed, there are currently 6299 other medical trials searching for participants.

Q: What is the enrollment cap for this medical trial?

This research is no longer seeking recruits. It was initially posted on January 21st 2014 and most recently updated as of October 3rd 2022. Currently, 6178 <a href="https://www.withpower.com/clinical-trials/cancer">cancer</a>-related trials and 41 propranolol hydrochloride investigations are actively enrolling patients if you're interested in other studies.

Phase < 1

Waitlist Available

Led By William Carson, MD

Research Sponsored by William Carson

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Be older than 18 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up up to 1 year

Awards & highlights

Study Summary

This trial is testing propranolol hydrochloride to see if it can treat patients with solid tumors that cannot be removed by surgery.

Eligible Conditions

Breast Cancer
Ovarian Germ Cell Tumor
Liver Cancer
Solid Tumors
Melanoma
Ovarian Cancer

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ up to 1 year

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~up to 1 year

This trial's timeline: 3 weeks for screening, Varies for treatment, and up to 1 year for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Change in vascular endothelial growth factor (VEGF)

Effect of beta-adrenergic blockade on the host immune system

Effect of beta-adrenergic blockade on the tumor microenvironment

+1 more

Secondary outcome measures

Overall survival

Progression-free survival

Trial Design

1Treatment groups

Experimental Treatment

Group I: Treatment (propranolol hydrochloride)Experimental Treatment2 Interventions

Patients receive propranolol hydrochloride PO BID for 4 months in the absence of disease progression or unacceptable toxicity. Propranolol will be administered on an out-patient basis. Blood for correlative studies (30 ml - green top tube) will be drawn at baseline and at each clinic visit. Tumor tissue for analysis will be obtained via core needle biopsy (or other appropriate modality) pre-study and at approximately the two month time point.

Treatment

First Studied

Drug Approval Stage

How many patients have taken this drug

Propranolol

FDA approved

Do I qualify?Apply below to find out

Find a Location

Who is running the clinical trial?

William CarsonLead Sponsor

2 Previous Clinical Trials

38 Total Patients Enrolled

William Carson, MDPrincipal InvestigatorOhio State University Comprehensive Cancer Center

5 Previous Clinical Trials

253 Total Patients Enrolled

1 Trials studying Breast Cancer

99 Patients Enrolled for Breast Cancer

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What medical ailments has propranolol hydrochloride been proven to alleviate?

"Propranolol hydrochloride has been utilized to reduce mortality from cardiovascular diseases, in addition to being beneficial for angina pectoris, myocardial infarction and obstructive hypertrophic cardiomyopathy."

Answered by AI

Are there any openings remaining for participants in this research?

"According to clinicaltrials.gov, this particular investigation is no longer solicitating volunteers; it was first shared on January 21st 2014 and had its most recent update in October 3rd 2022. While the trial has been closed, there are currently 6299 other medical trials searching for participants."

Answered by AI

What is the enrollment cap for this medical trial?

"This research is no longer seeking recruits. It was initially posted on January 21st 2014 and most recently updated as of October 3rd 2022. Currently, 6178 cancer-related trials and 41 propranolol hydrochloride investigations are actively enrolling patients if you're interested in other studies."

Answered by AI

Recent research and studies

clinicaltrials.govStudy

Propranolol Hydrochloride in Treating Patients With Locally Recurrent or Metastatic Solid Tumors That Cannot Be Removed By Surgery

William Carson 2014. "Propranolol Hydrochloride in Treating Patients With Locally Recurrent or Metastatic Solid Tumors That Cannot Be Removed By Surgery". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT02013492.