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Ferumoxytol for Childhood Brain Tumors

Q: To what capacity is this medical experiment recruiting participants?

Correct. According to clinicaltrials.gov, enrollment for this medical trial is currently open since its first posting in July 2017 and recent update on June 3rd 2022. A total of 10 patients are expected from one site participating in the study's activities.

Q: Have prior investigations been conducted concerning ferumoxytol-augmented MRI?

Presently, 15 experiments involving ferumoxytol-enhanced <a href="https://www.withpower.com/clinical-trials/mri">MRI</a> are running. Of these trials, 4 have reached Phase 3 clinical testing and can be found in <a href="https://www.withpower.com/clinical-trials/new-york">New york</a> City and an additional 40 locations across the United States.

Q: Are there any recruitment opportunities for participants of this clinical trial presently available?

Indeed, the clinicaltrials.gov site details that this trial is actively recruiting. It was first listed on July 1st 2017 and last updated June 3rd 2022; 10 patients are needed from a single healthcare centre.

Phase < 1

Waitlist Available

Research Sponsored by Michael Iv

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Timeline

Screening 3 weeks

Treatment Varies

Follow Up days 2-4

Awards & highlights

Study Summary

This trial looks at whether an MRI scan enhanced with ferumoxytol can show whether there is inflammation in the brain of children with cancer.

Eligible Conditions

Childhood Brain Tumor

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ days 2-4

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~days 2-4

This trial's timeline: 3 weeks for screening, Varies for treatment, and days 2-4 for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Iron concentration measurements

Secondary outcome measures

Macrophages on histopathology

Trial Design

1Treatment groups

Experimental Treatment

Group I: Diagnostic (ferumoxytol-enhanced MRI)Experimental Treatment4 Interventions

All subjects in the experimental arm will have a single intravenous dose of ferumoxytol (5 mg Fe/kg), to be administered 24 hours before the subject undergoes ferumoxytol-enhanced magnetic resonance imaging (MRI). These subjects will subsequently undergo surgery, and tissue analysis of surgically resected samples (specifically the number of iron-containing and non-iron-containing macrophages) will be correlated with imaging features on ferumoxytol-enhanced MRI.

Treatment

First Studied

Drug Approval Stage

How many patients have taken this drug

Ferumoxytol

2011

Completed Phase 4

~4380

Surgery

2000

Completed Phase 3

~2550

Do I qualify?Apply below to find out

Find a Location

Who is running the clinical trial?

Michael IvLead Sponsor

1 Previous Clinical Trials

10 Total Patients Enrolled

National Cancer Institute (NCI)NIH

13,658 Previous Clinical Trials

40,924,489 Total Patients Enrolled

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

To what capacity is this medical experiment recruiting participants?

"Correct. According to clinicaltrials.gov, enrollment for this medical trial is currently open since its first posting in July 2017 and recent update on June 3rd 2022. A total of 10 patients are expected from one site participating in the study's activities."

Answered by AI

Have prior investigations been conducted concerning ferumoxytol-augmented MRI?

"Presently, 15 experiments involving ferumoxytol-enhanced MRI are running. Of these trials, 4 have reached Phase 3 clinical testing and can be found in New york City and an additional 40 locations across the United States."

Answered by AI

Are there any recruitment opportunities for participants of this clinical trial presently available?

"Indeed, the clinicaltrials.gov site details that this trial is actively recruiting. It was first listed on July 1st 2017 and last updated June 3rd 2022; 10 patients are needed from a single healthcare centre."

Answered by AI

Recent research and studies

clinicaltrials.govStudy

In Vivo Characterization of Macrophages in Pediatric Patients With Malignant Brain Tumors Using Ferumoxytol-enhanced MRI

Michael Iv 2017. "In Vivo Characterization of Macrophages in Pediatric Patients With Malignant Brain Tumors Using Ferumoxytol-enhanced MRI". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT03179449.