Your session is about to expire
← Back to Search
Skin Immunity Sample Collection for Weak Immune Systems
Phase < 1
Waitlist Available
Led By Ian A Myles, M.D.
Research Sponsored by National Institute of Allergy and Infectious Diseases (NIAID)
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial Must have
Between the age limits of 18 and 65 years old for healthy volunteers; 7 and 65 years old for patients with CGD; 18 and 65 years old for patients with HIES.
Timeline
Screening 3 weeks
Treatment Varies
Follow Up throughout study
Awards & highlights
Study Summary
This trial is testing whether different liquids applied to the skin can help heal blisters and improve the immune response in people with weak immune systems.
Who is the study for?
This trial is for people aged 18-65 with hyper IgE syndrome or Job syndrome, those aged 7-65 with chronic granulomatous disease, and healthy volunteers of the same age range. Participants must be willing to allow their samples to be stored for research and able to give informed consent. Those with a history of severe scarring, recent blood thinners or immunomodulatory drugs use, or pregnancy cannot join.Check my eligibility
What is being tested?
Researchers are studying how the immune system relates to skin healing by inducing blisters and taking skin biopsies from participants. They will collect blister fluid and small pieces of skin using a suction device and sharp tool respectively. Some may have an overnight visit where their wounds are treated with saline or their own blood serum.See study design
What are the potential side effects?
Participants might experience discomfort from the blistering process and minor pain from biopsy procedures. There's also a risk of infection at the site of these interventions as well as potential bruising or bleeding.
Eligibility Criteria
Inclusion Criteria
You may be eligible if you check “Yes” for the criteria belowSelect...
I am within the age range required for my health status.
Timeline
Screening ~ 3 weeks3 visits
Treatment ~ Varies
Follow Up ~ throughout study
Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~throughout study
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.Primary outcome measures
Fold induction in genes related to wound healing.
T-cell infiltration as percent of total cell infiltration in patients with CGD versus healthy volunteers.
Tumor necrosis factor alpha (TNFa) production by keratinocytes from patients with HIES versus healthy volunteers
Trial Design
2Treatment groups
Experimental Treatment
Group I: 2Experimental Treatment1 Intervention
Skin Biopsies
Group II: 1Experimental Treatment1 Intervention
Blister Induction
Find a Location
Who is running the clinical trial?
National Institute of Allergy and Infectious Diseases (NIAID)Lead Sponsor
3,269 Previous Clinical Trials
5,481,399 Total Patients Enrolled
Ian A Myles, M.D.Principal InvestigatorNational Institute of Allergy and Infectious Diseases (NIAID)
5 Previous Clinical Trials
530 Total Patients Enrolled
Media Library
Eligibility Criteria:
This trial includes the following eligibility criteria:- I have been on blood thinners or anti-clotting medication in the last 3 months.I agree to let my samples be stored for future research.I haven't used any immune-affecting drugs in the last 3 months, or it's approved.You have a documented immune disorder, or you do not show signs of immune problems or a history of severe Staphylococcus aureus infections.I have a history of keloid formation after skin procedures.I am within the age range required for my health status.
Research Study Groups:
This trial has the following groups:- Group 1: 1
- Group 2: 2
Awards:
This trial has 1 awards, including:- No Placebo-Only Group - All patients enrolled in this study will receive some form of active treatment.
Timeline:
This trial has the following timeline:- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Frequently Asked Questions
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Does this experiment involve participants over the age of forty?
"For this medical trial, enrolment is restricted to individuals aged 7-65. There are 16 specific trials tailored for those under 18 and 13 designed specifically for older adults over 65 years old."
Answered by AI
Am I eligible to partake in this research program?
"To partake in this medical trial, applicants must be within the age range of 7 and 65 years old with a diagnosis of granulomatous disease. This study is currently seeking to recruit 70 participants."
Answered by AI
Is this trial taking in new participants?
"Unfortunately, patient recruitment for this study has been halted as of December 1st 2022. Nevertheless, 21 other medical trials are presently enrolling volunteers."
Answered by AI
Recent research and studies
Other Trials to Consider
Popular Categories
Share this study with friends
Copy Link
Messenger