← Back to Search

Dexmedetomidine for Anesthesia

Q: Could I be considered a participant in this research endeavor?

This research study is seeking out 30 adults aged 18-45 for anaesthesia therapy. To be eligible, potential participants must have no known contraindications to <a href="https://www.withpower.com/clinical-trials/mri">MRI</a> or PET scans.

Q: Does this experiment restrict participation to those aged 50 or younger?

The age range for potential study enrollees is from 18 to 45 years old, as specified by the trial's eligibility requirements.

Q: Are there still available openings for participants in this research project?

Affirmative. Clinicaltrials.gov reveals that this medical study, which was first published on April 12th 2022, is still in search of volunteers. Approximately 30 participants need to be sourced from a single clinical centre.

Q: How many participants are currently involved in this research endeavor?

Affirmative. The clinical trial data on clinicaltrials.gov reveals that this research study is actively seeking participants and began recruitment on April 12th, 2022 with a recent update issued June 23rd of the same year. A total of 30 patients are needed from 1 medical site for enrollment in the trial.

Phase < 1

Recruiting

Led By Christin Y Sander, PhD

Research Sponsored by Massachusetts General Hospital

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Be between 18 and 65 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up 2 hours

Awards & highlights

Study Summary

This trial will use dexmedetomidine, a sedative, to study how anesthesia and artificially induced sleep affects the brain.

Eligible Conditions

Anesthesia
Healthy Subjects

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ 2 hours

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~2 hours

This trial's timeline: 3 weeks for screening, Varies for treatment, and 2 hours for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Brain positron emission tomography (PET) imaging signals.

Differences in electroencephalography (EEG) measures between arousal and anesthesia.

Functional magnetic resonance imaging (fMRI) signals.

Secondary outcome measures

Heart rate

Oximetry, Pulse

Respiratory physiology

Side effects data

From 2020 Phase 4 trial • 798 Patients • NCT02004613

57%

Clinically important hypotension

Clinically important bradycardia

infection

stroke

Atelectasis

Hemorrhage

100%

80%

60%

40%

20%

Study treatment Arm

Placebo

Dexmedetomidine

Trial Design

2Treatment groups

Experimental Treatment

Placebo Group

Group I: DexmedetomidineExperimental Treatment1 Intervention

During the imaging scan subjects will receive an initial 1µg/kg bolus of dexmedetomidine up to a maximum dose of 80 µg, infused through IV over 10 minutes. After the bolus has been administered, a constant infusion of up to 0.6 µg/kg/hr (0.01 µg/kg/min) of dexmedetomidine will be maintained for the remainder of the scan (about 60 minutes).

Group II: SalinePlacebo Group1 Intervention

A saline infusion will be used as a placebo comparator for the dexmedetomidine infusion. It will be administered in the same manner and dosages as the dexmedetomidine.

Treatment

First Studied

Drug Approval Stage

How many patients have taken this drug

Dexmedetomidine

FDA approved

Do I qualify?Apply below to find out

Find a Location

Who is running the clinical trial?

Boston UniversityOTHER

454 Previous Clinical Trials

9,941,540 Total Patients Enrolled

Massachusetts General HospitalLead Sponsor

2,928 Previous Clinical Trials

13,198,325 Total Patients Enrolled

Christin Y Sander, PhDPrincipal InvestigatorAthinoula A. Martinos Center for Biomedical Imaging

1 Previous Clinical Trials

30 Total Patients Enrolled

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Could I be considered a participant in this research endeavor?

"This research study is seeking out 30 adults aged 18-45 for anaesthesia therapy. To be eligible, potential participants must have no known contraindications to MRI or PET scans."

Answered by AI

Does this experiment restrict participation to those aged 50 or younger?

"The age range for potential study enrollees is from 18 to 45 years old, as specified by the trial's eligibility requirements."

Answered by AI

Are there still available openings for participants in this research project?

"Affirmative. Clinicaltrials.gov reveals that this medical study, which was first published on April 12th 2022, is still in search of volunteers. Approximately 30 participants need to be sourced from a single clinical centre."

Answered by AI

How many participants are currently involved in this research endeavor?

"Affirmative. The clinical trial data on clinicaltrials.gov reveals that this research study is actively seeking participants and began recruitment on April 12th, 2022 with a recent update issued June 23rd of the same year. A total of 30 patients are needed from 1 medical site for enrollment in the trial."

Answered by AI

Recent research and studies

clinicaltrials.govStudy

Neurochemical Mechanisms of the Awake vs. Anesthetized Brain

Christin Y. Sander, PhD 2022. "Neurochemical Mechanisms of the Awake vs. Anesthetized Brain". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT05435560.