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11C-PIB for Alzheimer's Disease (DPPOS-Brain Trial)

Phase < 1
Waitlist Available
Led By F. X. Pi-Sunyer, MD
Research Sponsored by José A. Luchsinger
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up up to 1 hour post-injection
Awards & highlights

DPPOS-Brain Trial Summary

This study is evaluating whether brain imaging biomarkers are associated with diabetes prevention program outcomes.

DPPOS-Brain Trial Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~up to 1 hour post-injection
This trial's timeline: 3 weeks for screening, Varies for treatment, and up to 1 hour post-injection for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Brain Amyloid SUVR
Brain Tau SUVR
Secondary outcome measures
Hippocampal Cortical Thickness
White Matter Hyper Intensity Volume

Side effects data

From 2016 Phase 2 trial • 89 Patients • NCT01607476
3%
Leg cramp (mild)
3%
Decreased vision
3%
Heart palpitations (moderate)
3%
Metallic taste
100%
80%
60%
40%
20%
0%
Study treatment Arm
Cognitive Normal Elderly
Alzheimer's Disease
Cognitive Normal Young

DPPOS-Brain Trial Design

2Treatment groups
Experimental Treatment
Active Control
Group I: DPPOS Exposed to MetforminExperimental Treatment2 Interventions
DPPOS participants with exposure to metformin will be scanned with 18F-MK-6240 and 11C-PIB.
Group II: DPPOS Exposed to PlaceboActive Control2 Interventions
DPPOS participants with no exposure to metformin but only placebo will be scanned with 18F-MK-6240 and 11C-PIB.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
18F-MK-6240
2019
Completed Phase 2
~220

Find a Location

Who is running the clinical trial?

Albert Einstein College of MedicineOTHER
287 Previous Clinical Trials
11,857,103 Total Patients Enrolled
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)NIH
2,359 Previous Clinical Trials
4,314,586 Total Patients Enrolled
George Washington UniversityOTHER
243 Previous Clinical Trials
453,769 Total Patients Enrolled

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Recent research and studies
clinicaltrials.govStudy
Brain Imaging in the Diabetes Prevention Program Outcomes Study
José A. Luchsinger 2019. "Brain Imaging in the Diabetes Prevention Program Outcomes Study". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT03757910.
~1 spots leftby Apr 2025
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