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Vitamin D Analog

Calcipotriol for Central Centrifugal Alopecia (CCCA Trial)

Phase < 1
Waitlist Available
Led By Amy McMichael, MD
Research Sponsored by Wake Forest University Health Sciences
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up month 2, month 4, and month 6
Awards & highlights

CCCA Trial Summary

This trial will test whether calcipotriol can help treat Central Centrifugal Cicatricial Alopecia, by evaluating its possible anti-inflammatory effects on the hair growth cycle.

Eligible Conditions
  • Central Centrifugal Cicatricial Alopecia

CCCA Trial Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~month 2, month 4, and month 6
This trial's timeline: 3 weeks for screening, Varies for treatment, and month 2, month 4, and month 6 for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Amount of hairline stabilization
Secondary outcome measures
Amount of hair regrowth
Dermatology Life Quality Index score
Signs and symptoms of disease score

Side effects data

From 2010 Phase 3 trial • 1245 Patients • NCT00691002
7%
Psoriasis
3%
Headache
2%
Erythema
2%
Nasopharyngitis
2%
Pruritus
1%
Rhinitis
1%
Diarrhoea
1%
Toothache
1%
Application site pruritus
1%
Pyrexia
1%
Herpes simplex
1%
Influenza
1%
Burning sensation
1%
Skin irritation
100%
80%
60%
40%
20%
0%
Study treatment Arm
LEO 80190
Calcipotriol
Hydrocortisone
LEO 80190 Vehicle
Open-label Phase

CCCA Trial Design

2Treatment groups
Experimental Treatment
Placebo Group
Group I: Calcipotriol GroupExperimental Treatment1 Intervention
Subjects will use the topical formulation once daily on the scalp. The subjects will use the treatment for a total of 6 months.
Group II: Control GroupPlacebo Group1 Intervention
Subjects will continue to use their primary physician prescribed topical formulation once daily on the scalp. The subjects will use their treatment for a total of 6 months.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Calcipotriol
FDA approved

Find a Location

Who is running the clinical trial?

Wake Forest University Health SciencesLead Sponsor
1,240 Previous Clinical Trials
1,004,207 Total Patients Enrolled
Amy McMichael, MDPrincipal InvestigatorWake Forest University Health Sciences
6 Previous Clinical Trials
233 Total Patients Enrolled

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is there still availability for individuals to participate in this research project?

"Per the information on clinicaltrials.gov, this experiment is no longer recruiting patients; it was originally posted on January 1st 2023 and last updated October 19th 2022. Fortunately, there are currently 85 other experiments that individuals can take part in."

Answered by AI

Who else is applying?

What state do they live in?
North Carolina
How old are they?
18 - 65
What site did they apply to?
Wake Forest University Health Sciences
What portion of applicants met pre-screening criteria?
Met criteria
How many prior treatments have patients received?
1

What questions have other patients asked about this trial?

Any cost ? How long do screening visits take?
PatientReceived 2+ prior treatments

Why did patients apply to this trial?

Trying to get help found hair loss.
PatientReceived no prior treatments

How responsive is this trial?

Typically responds via
Email
Recent research and studies
clinicaltrials.govStudy
Calcipotriol as a Novel Treatment for Central Centrifugal Cicatricial Alopecia (CCCA)
2023. "Calcipotriol as a Novel Treatment for Central Centrifugal Cicatricial Alopecia (CCCA)". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT05416320.
~0 spots leftby Apr 2025
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