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Vitamin D Analog

Calcipotriol for Central Centrifugal Alopecia (CCCA Trial)

Phase < 1
Waitlist Available
Led By Amy McMichael, MD
Research Sponsored by Wake Forest University Health Sciences
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up month 2, month 4, and month 6
Awards & highlights

Summary

This trial is testing calcipotriol, a vitamin D-like cream, on patients with CCCA. These patients often have low vitamin D levels. The cream may help by reducing inflammation and supporting immune health around hair follicles. Calcipotriol has been studied for its effectiveness in treating conditions like psoriasis and alopecia areata.

Eligible Conditions
  • Central Centrifugal Cicatricial Alopecia

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~month 2, month 4, and month 6
This trial's timeline: 3 weeks for screening, Varies for treatment, and month 2, month 4, and month 6 for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Amount of hairline stabilization
Secondary outcome measures
Amount of hair regrowth
Dermatology Life Quality Index score
Signs and symptoms of disease score

Side effects data

From 2010 Phase 3 trial • 1245 Patients • NCT00691002
7%
Psoriasis
3%
Headache
2%
Pruritus
2%
Erythema
2%
Nasopharyngitis
1%
Pyrexia
1%
Herpes simplex
1%
Skin irritation
1%
Rhinitis
1%
Diarrhoea
1%
Toothache
1%
Application site pruritus
1%
Influenza
1%
Burning sensation
100%
80%
60%
40%
20%
0%
Study treatment Arm
LEO 80190
Calcipotriol
Hydrocortisone
LEO 80190 Vehicle
Open-label Phase

Trial Design

2Treatment groups
Experimental Treatment
Placebo Group
Group I: Calcipotriol GroupExperimental Treatment1 Intervention
Subjects will use the topical formulation once daily on the scalp. The subjects will use the treatment for a total of 6 months.
Group II: Control GroupPlacebo Group1 Intervention
Subjects will continue to use their primary physician prescribed topical formulation once daily on the scalp. The subjects will use their treatment for a total of 6 months.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Calcipotriol
FDA approved

Find a Location

Who is running the clinical trial?

Wake Forest University Health SciencesLead Sponsor
1,253 Previous Clinical Trials
1,010,932 Total Patients Enrolled
Amy McMichael, MDPrincipal InvestigatorWake Forest University Health Sciences
6 Previous Clinical Trials
233 Total Patients Enrolled
~0 spots leftby Sep 2025
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