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Gentle Wounding for Hair Growth

Q: Are there still enrollments available for this clinical experiment?

Unfortunately, this specific trial is no longer accepting candidates. Initially listed on the first of January 2018 and last updated nearly 4 years later on June 8th 2022, it has closed its recruitment period. However, there are currently a combined 106 trials recruiting patients with either <a href="https://www.withpower.com/clinical-trials/alopecia-areata">alopecia areata</a> or Laser-related conditions.

Q: Who has the opportunity to partake in this research?

This trial is currently enrolling 20 individuals aged 18-80 with <a href="https://www.withpower.com/clinical-trials/alopecia-areata">alopecia areata</a>. To participate, candidates must be able to follow the protocol's instructions and prohibitions, including any washout periods that may apply; they should also demonstrate good health as determined by a medical assessment of their CCCA grades (2, 3, or 4).

Q: Are individuals over a certain age permitted to participate in this clinical trial?

As it stands, the eligibility criteria for this clinical trial necessitates that participants are aged 18-80. Conversely, there is a separate study available for those younger than 18 and another one open to individuals over 65 years of age.

Q: What medical ailments is Laser commonly prescribed to treat?

Severe, persistent cystic <a href="https://www.withpower.com/clinical-trials/acne">acne</a> is typically treated with Laser therapy. This method of treatment has also been used to reduce the roughness of facial skin and assist in sun avoidance programs.

Q: What is the current number of participants involved in this research?

This trial has already concluded recruitment, with the initial posting occurring on January 1st 2018 and the last edit made on June 8th 2022. However, if you are exploring additional studies, there are 85 clinical trials devoted to <a href="https://www.withpower.com/clinical-trials/alopecia-areata">alopecia areata</a> still recruiting and 21 Laser-based studies that require patients.

Q: Has there been any other research done utilizing Laser technology?

Presently, there are 21 clinical trials assessing the efficacy of Laser. Of those studies, 4 have reached Phase 3 and many more are being conducted at 253 sites across America; particularly in Baltimore, <a href="https://www.withpower.com/clinical-trials/maryland">Maryland</a>.

Phase < 1

Waitlist Available

Led By Luis Garza, MD/PhD

Research Sponsored by Johns Hopkins University

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

The subject is willing and able to comply with the requirements of the protocol. In particular, subject must adhere to the visits schedule, concomitant therapy and hair processing prohibitions, subject instructions, and biopsy procedures

The subject's CCCA is of grades 2, 3 or 4, as assessed at the time of the screening visit

Timeline

Screening 3 weeks

Treatment Varies

Follow Up within 1 year of treatment

Awards & highlights

Study Summary

This trial will test whether gentle wounding of the scalp can cause the generation of new hair follicles in humans.

Who is the study for?

This trial is for adults over 18 with a clinical diagnosis of Central Centrifugal Cicatricial Alopecia (CCCA) grades 2-4. Participants must be healthy, able to follow the study's protocol and visit schedule, and not have any skin conditions or tattoos in the treatment area. Pregnant or breastfeeding individuals, those with allergies to local anesthetics or antiseptics used in procedures, and anyone at risk due to medical conditions are excluded.Check my eligibility

What is being tested?

The study tests if gentle wounding on the scalp can stimulate new hair growth in humans as it does in mice. It involves mapping bald areas of the scalp then applying treatments like CO2 laser and retinoic acid. The treated areas will be monitored visually and through biopsies to check for hair regrowth.See study design

What are the potential side effects?

Potential side effects may include skin irritation from retinoic acid application, discomfort or pain from laser treatment, risks associated with biopsies such as infection or scarring, and possible allergic reactions to topical medications used during procedures.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

Select...

I am willing and able to follow all study requirements, including visit schedules and instructions.

Select...

My CCCA is graded between 2 and 4.

Select...

I am over 18 years old.

Select...

I have been diagnosed with CCCA.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ within 1 year of treatment

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~within 1 year of treatment

This trial's timeline: 3 weeks for screening, Varies for treatment, and within 1 year of treatment for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Hair follicle structure

Side effects data

From 2017 Phase 3 trial • 384 Patients • NCT02259088

Upper respiratory tract infection

Nasopharyngitis

Cough

Hypertension

Urinary tract infection

Intraocular pressure increased (Study eye)

Conjunctival haemorrhage (Study eye)

Dry eye (Study eye)

Vitreous haemorrhage (Fellow eye)

Dry eye (Fellow eye)

Anaemia

Hyperlipidaemia

Diabetic nephropathy

Coronary artery disease

Vitreous haemorrhage (Study eye)

Cerebral infarction

Diabetic neuropathy

Angina unstable

Lung infection

Pneumonia

Diabetes mellitus inadequate control

Hypoglycaemia

Cataract (Fellow eye)

Chronic obstructive pulmonary disease

Diabetic vascular disorder

Alanine aminotransferase increased

100%

80%

60%

40%

20%

Study treatment Arm

Ranibizumab (RFB002)

Laser

Trial Design

2Treatment groups

Experimental Treatment

Group I: Subjects with alopecia-- area un-treatedExperimental Treatment1 Intervention

One area will be un-treated

Group II: Subjects with alopecia-- area treatedExperimental Treatment2 Interventions

One area will be treated

Treatment

First Studied

Drug Approval Stage

How many patients have taken this drug

Retinoic acid

2015

Completed Early Phase 1

~50

Laser

2008

Completed Phase 4

~2170

Sham treatment

2013

Completed Phase 3

~1260

0 / 4Eligibility criteria met

Find a Location

Who is running the clinical trial?

Johns Hopkins UniversityLead Sponsor

2,258 Previous Clinical Trials

14,820,513 Total Patients Enrolled

Luis Garza, MD/PhDPrincipal InvestigatorJohns Hopkins University

Media Library

Laser Clinical Trial Eligibility Overview. Trial Name: NCT03491267 — Phase < 1

Central Centrifugal Alopecia Research Study Groups: Subjects with alopecia-- area treated, Subjects with alopecia-- area un-treated

Central Centrifugal Alopecia Clinical Trial 2023: Laser Highlights & Side Effects. Trial Name: NCT03491267 — Phase < 1

Laser 2023 Treatment Timeline for Medical Study. Trial Name: NCT03491267 — Phase < 1

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Are there still enrollments available for this clinical experiment?

"Unfortunately, this specific trial is no longer accepting candidates. Initially listed on the first of January 2018 and last updated nearly 4 years later on June 8th 2022, it has closed its recruitment period. However, there are currently a combined 106 trials recruiting patients with either alopecia areata or Laser-related conditions."

Answered by AI

Who has the opportunity to partake in this research?

"This trial is currently enrolling 20 individuals aged 18-80 with alopecia areata. To participate, candidates must be able to follow the protocol's instructions and prohibitions, including any washout periods that may apply; they should also demonstrate good health as determined by a medical assessment of their CCCA grades (2, 3, or 4)."

Answered by AI

Are individuals over a certain age permitted to participate in this clinical trial?

"As it stands, the eligibility criteria for this clinical trial necessitates that participants are aged 18-80. Conversely, there is a separate study available for those younger than 18 and another one open to individuals over 65 years of age."

Answered by AI

What medical ailments is Laser commonly prescribed to treat?

"Severe, persistent cystic acne is typically treated with Laser therapy. This method of treatment has also been used to reduce the roughness of facial skin and assist in sun avoidance programs."

Answered by AI

What is the current number of participants involved in this research?

"This trial has already concluded recruitment, with the initial posting occurring on January 1st 2018 and the last edit made on June 8th 2022. However, if you are exploring additional studies, there are 85 clinical trials devoted to alopecia areata still recruiting and 21 Laser-based studies that require patients."

Answered by AI

Has there been any other research done utilizing Laser technology?

"Presently, there are 21 clinical trials assessing the efficacy of Laser. Of those studies, 4 have reached Phase 3 and many more are being conducted at 253 sites across America; particularly in Baltimore, Maryland."

Answered by AI

Recent research and studies

clinicaltrials.govStudy

Study to Determine Effect of Gentle Wounding to Stimulate Hair Follicle Neogenesis

2018. "Study to Determine Effect of Gentle Wounding to Stimulate Hair Follicle Neogenesis". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT03491267.

All > Androgenetic Alopecia > Alopecia Areata