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Anti-epileptic drug

Topiramate and N-Acetyl Cysteine for Alcoholism

Phase < 1
Waitlist Available
Led By Nassima Ait-Daoud Tiouririne, M.D.
Research Sponsored by Nassima Ait-Daoud Tiouririne
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up drinc is at screen, weeks 1,5,9, and 13
Awards & highlights

Study Summary

This is a pilot study designed to evaluate the safety, tolerability of Topiramate (TPM) + N-Acetyl Cysteine (NAC) in combination versus Topiramate (TPM) + placebo for the treatment of alcohol use disorder (AUD).

Eligible Conditions
  • Alcoholism

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~drinc is at screen, weeks 1,5,9, and 13
This trial's timeline: 3 weeks for screening, Varies for treatment, and drinc is at screen, weeks 1,5,9, and 13 for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Cognitive side effects
Secondary outcome measures
Clinical Global Improvement (CGI) scale
Drinking Inventory of Consequence (DrInC) scale
Drinks per Drinking Day
+3 more

Trial Design

2Treatment groups
Experimental Treatment
Group I: Topiramate and PlaceboExperimental Treatment1 Intervention
Drug: Topiramate and Placebo Other Name for Topiramate: Topamax Other Name for Placebo: Sugar Pill
Group II: Topiramate and N-Acetyl CysteineExperimental Treatment1 Intervention
Drug: Topiramate and N-Acetyl Cysteine Other Name for Topiramate: Topamax

Find a Location

Who is running the clinical trial?

Nassima Ait-Daoud TiouririneLead Sponsor
2 Previous Clinical Trials
220 Total Patients Enrolled
1 Trials studying Alcoholism
20 Patients Enrolled for Alcoholism
Nassima Ait-Daoud Tiouririne, M.D.Principal InvestigatorUniversity of Virginia
3 Previous Clinical Trials
1,308 Total Patients Enrolled

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Recent research and studies
clinicaltrials.govStudy
Topiramate Augmenting Strategies for the Treatment of Alcohol Use Disorder
Nassima Ait-Daoud Tiouririne 2017. "Topiramate Augmenting Strategies for the Treatment of Alcohol Use Disorder". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT03120468.
~2 spots leftby Apr 2025
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