This trial is evaluating whether Methamphetamine will improve 1 primary outcome in patients with Mood. Measurement will happen over the course of Time Frame: Day 1(baseline), 3.
This trial requires 30 total participants across 2 different treatment groups
This trial involves 2 different treatments. Methamphetamine is the primary treatment being studied. Participants will be divided into 2 treatment groups. Some patients will receive a placebo treatment. The treatments being tested are in Phase < 1 and are in the first stage of evaluation with people.
"Results from a recent paper support the need for an additional source of Hs in order to accurately monitor and measure the overall burden of disease. The use of existing Hs as a metric for the burden of disease may underestimate the total burden of disease if the Hs include a subset of individuals who are at risk for developing disease." - Anonymous Online Contributor
"Common treatments include aspirin for dyslipidemia, statins, or fibrates. The use of antihypertensive medications is common but should be used cautiously because they may interact with warfarin and clopidogrel. These medications are not always used appropriately." - Anonymous Online Contributor
"- Healthy subjects (hs) are asymptomatic.\n- Healthy subjects (hs) are not able to discriminate between the different types of hand tools in the testing room.\n- Healthy subjects (hs) show better hand skill than do subjects with hand problems as evidenced by the fact that the former can finish the tests sooner.\n- Healthy subjects (hs) are able to draw more accurately than subjects with hand problems.\nThe hand performance of healthy subjects (hs) and subjects with hand problems does not differ in the test room environment, that is, healthy subjects (hs) can discriminate between tools." - Anonymous Online Contributor
"The causes of healthy subjects are currently unknown. But, several factors have been associated with the development of healthy subjects in the past, including some factors, such as genetics, aging, smoking, physical activity, intake in the diet, and drugs or environmental toxicants. However, these factors may not contribute to explain, for example, about 65% of the variation in healthy subjects found in the United States." - Anonymous Online Contributor
"Hs represent a common and reproducible subpopulation of the general population that are considered to be a homogenous population as they share similar characteristics with regards to age, sex and socio-economical status. Thus, the results obtained in Hs represent the true pattern of human aging. Hs are a very important human model in the study of human aging, since they have minimal changes compared to the main features of human aging, such as age-related changes in the body." - Anonymous Online Contributor
"Fungi (Candida albicans and Candida dubliniensis) had a low prevalence but a high recidivism rate in hs during oral candidiasis. Oral candidiasis is associated with symptomatic candidiasis at ages 3-6 weeks postnatally and is associated with thrush at 2 years of age. In hs, recidivism is low and symptoms are atypical." - Anonymous Online Contributor
"Currently, there are no FDA-regulated drugs and therapies that have been approved specifically for treating healthy subjects. However, there are a few drugs and therapies that can treat multiple hs conditions. Additionally, there are several clinical trials that use a "healthy subjects plus" component, where participants who are not healthy are also included as subjects. More research has to be done in this area to determine if and how the safety and efficacy of these drugs and therapies can be evaluated and regulated." - Anonymous Online Contributor
"Results from this study suggest that methamphetamine use is associated with improvements in some domains of QOL. These improvements in QOL are particularly pronounced in women and those with higher baseline levels of psychological distress; hence, methamphetamine use should be considered a possible treatment strategy when other drugs are not tolerated." - Anonymous Online Contributor
"Healthy subjects are an average age 55. (https://www.endocrineonline.org/pages/about/pages/health.aspx) In the United States, the majority of people diagnosed with a disease are [older than 60 or younger than 18 (https://www.ende.ncts.gov/pub/beprogram/BPP/index.aspx)], and the average person getting healthy is more than 60 years. People getting healthy are also healthier. People getting healthy would be an hs-like age 55 for women and an hs-like age 40 for men." - Anonymous Online Contributor
"The data support a model of METH being able to enhance dopamine transporter availability in the striatum, thereby increasing striatal DAT availability and releasing endogenous DA in the putamen and nucleus accumbens. Both the putamen and the caudate may be important for this action as the latter could mediate METH-induced euphoria and enhanced behavioral responses to cocaine. However, since plasma METH levels were similar to those found following previous intracranial METH use, these changes are likely to result from sustained, though not recurrent, use of METH rather than a direct effect of METH on the striatum or other brain regions." - Anonymous Online Contributor
"[A cohort of patients undergoing clinical trials may have the potential to be representative for the general population of the country, and thus hs may be appropriate study groups for studies targeted to address the broadest range of research questions in general clinical research.] The general population may represent the population of interest to clinical trialists, the hs, and the patients." - Anonymous Online Contributor
"Methamphetamine use is likely common in both clinical trials and community-based studies. Methamphetamine may be a useful clinical probe to understand the nature of drug-induced cognitive change." - Anonymous Online Contributor