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Methamphetamine Impact on Brain Function in Healthy Subjects (DEG Trial)

Phase < 1
Waitlist Available
Led By Harriet de Wit
Research Sponsored by University of Chicago
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be between 18 and 65 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up time frame: day 1(baseline), 3
Awards & highlights

DEG Trial Summary

This trial will examine the effects of the drug MA on reward function using electroencephalograms (EEG).

Who is the study for?
This trial is for healthy adults who consume less than 4 alcoholic or caffeinated drinks daily and have a BMI between 19-26. It's not for those on regular medication, with high blood pressure, pregnant women, anyone trying to conceive, people with a history of stimulant drug dependence or current mental health disorders.Check my eligibility
What is being tested?
The study tests the effects of Methamphetamine (MA) on brain reward function using EEG. Participants will take MA at two different doses and a placebo in three sessions while doing tasks related to reward anticipation and inhibition control.See study design
What are the potential side effects?
Methamphetamine may cause increased feelings of alertness and well-being but can also lead to side effects like rapid heart rate, elevated blood pressure, euphoria, potential addiction risk, and negative mood changes after it wears off.

DEG Trial Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~time frame: day 1(baseline), 3
This trial's timeline: 3 weeks for screening, Varies for treatment, and time frame: day 1(baseline), 3 for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Change in SUbjective Effects as Assessed by Score on "Feel Drug", "Feel High", "Like Drug", and "Want More" Sub-scales of Drug Effects Questionnaire (DEQ).

Side effects data

From 2021 Phase 1 trial • 8 Patients • NCT04178993
50%
Elevated Blood Pressure
50%
Elevated Heart Rate
100%
80%
60%
40%
20%
0%
Study treatment Arm
Placebo Comparator: Placebo
Active Comparator: Duloxetine (60 mg)

DEG Trial Design

2Treatment groups
Experimental Treatment
Group I: Placebo Then MethamphetamineExperimental Treatment2 Interventions
Participants first receive placebo at their first session in the laboratory. Then will return to the laboratory 72 hours later and will receive 20 mg methamphetamine.
Group II: Methamphetamine Then PlaceboExperimental Treatment2 Interventions
Participants first receive 20 mg methamphetamine at their first session in the laboratory Then will return to the laboratory 72 hours later and will receive placebo.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Placebo
1995
Completed Phase 3
~2670
Methamphetamine
2013
Completed Phase 1
~130

Find a Location

Who is running the clinical trial?

University of ChicagoLead Sponsor
1,001 Previous Clinical Trials
817,690 Total Patients Enrolled
19 Trials studying Depression
11,259 Patients Enrolled for Depression
Harriet de WitPrincipal InvestigatorUniversity of Chicago
6 Previous Clinical Trials
341 Total Patients Enrolled

Media Library

Brain Function and EEG (Other) Clinical Trial Eligibility Overview. Trial Name: NCT05003076 — Phase < 1
Depression Research Study Groups: Methamphetamine Then Placebo, Placebo Then Methamphetamine
Depression Clinical Trial 2023: Brain Function and EEG Highlights & Side Effects. Trial Name: NCT05003076 — Phase < 1
Brain Function and EEG (Other) 2023 Treatment Timeline for Medical Study. Trial Name: NCT05003076 — Phase < 1
Depression Patient Testimony for trial: Trial Name: NCT05003076 — Phase < 1

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is there an age restriction for participation in this medical trial?

"The upper and lower age limits for eligibility are 18 and 35 years old, respectively."

Answered by AI

Who is qualified to participate in this trial?

"This study is looking for 30 individuals in the 18-35 age group with mood disorders. The BMI must be 19 to 26 and no more than 4 alcoholic or caffeinated drinks may be consumed daily."

Answered by AI

Does the trial offer opportunities for participants at this time?

"Clinicaltrials.gov indicates that this clinical trial is still recruiting participants, with the original advertisement posted on July 1st 2021 and a subsequent update published in January of 2022"

Answered by AI

What other research has been undertaken on Methamphetamine?

"Currently, there are 5 ongoing research studies looking into the effects of Methamphetamine with none reaching Phase 3. These trials are largely based in the city of Chicago but encompass 8 different medical sites across America."

Answered by AI

What is the aggregate population enrolled in this clinical trial?

"Affirmative. According to clinicaltrials.gov, this medical research is presently recruiting participants. The trial was initiated on July 1st 2021 and the details were last updated on January 21st 2022; it aims to acquire 30 patients from one site."

Answered by AI

Who else is applying?

What state do they live in?
Massachusetts
Texas
California
Other
How old are they?
65+
18 - 65
What site did they apply to?
University of Chicago
What portion of applicants met pre-screening criteria?
Did not meet criteria
Met criteria
How many prior treatments have patients received?
0

What questions have other patients asked about this trial?

1. How many visits?
PatientReceived 2+ prior treatments

Why did patients apply to this trial?

I would like to better understand how it would help me. All applies to me . meth addiction & bmi is 23.6 so i qualify for that also .
PatientReceived 2+ prior treatments
I've suffered from episodes of depression most of my life. I've been prescribed countless depression medications over the years. Absolutely none helped at all. So I have been off the meds for years with same depression episodes as to when I was on depression meds.
PatientReceived no prior treatments
I have tried what they normally prescribe and it doesn't work but it's been a while ago (Wellbutrin and some other B.S.) I was in a major wreck January of 2022 and haven't walked since or been able to work or contribute to anything and I am sick to death of this ****.
PatientReceived 2+ prior treatments
Recent research and studies
clinicaltrials.govStudy
Brain Function and EEG
2021. "Brain Function and EEG". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT05003076.
~11 spots leftby Apr 2025
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