This trial is evaluating whether Acetylcholine will improve 17 primary outcomes and 10 secondary outcomes in patients with Vasodilation. Measurement will happen over the course of Change in baseline endothelial MnSOD at 8 weeks.
This trial requires 60 total participants across 2 different treatment groups
This trial involves 2 different treatments. Acetylcholine is the primary treatment being studied. Participants will all receive the same treatment. Some patients will receive a placebo treatment. The treatments being tested are in Phase < 1 and are in the first stage of evaluation with people.
"The treatment of pulmonary hypertension with NO and prostaglandins has had a large beneficial effect on patients, mainly due to improved arterial oxygenation. In patients with pulmonary hypertension, vasodilation of the pulmonary arteries with NO can be cure with low-dose vasodilators or by suppressing right-heart failure-related increase in aortic stiffness. Pulmonary hypertension, however, must be considered a lifelong necessity." - Anonymous Online Contributor
"Vasodilation can cause increased blood flow in arteries and capillaries and it induces the release of arterial and capillary dilating hormones that activate various pathways that lead to the opening of potassium ion channels and the formation of a hyperpolarizing hyperpolarization potential and, at a more rapid rate, calcium-activated potassium channels.\n\n- Overview at kennej.com"" - Anonymous Online Contributor
"There is a close association between age, female sex and lower plasma angiotensin II. This might be because vasodilation is generally required to limit circulating blood pressure, and reduced angiotensin II levels could in consequence lead to higher blood pressure and, therefore, increased disease risk." - Anonymous Online Contributor
"The most common treatment for vasodilation is medications. This is a first step in the treatment for vasodilation. Although this treatment is not an absolute cures for vasodilation and patients may have to take a different type of medication over the course of time in order to achieve results. The number of people affected at one time might be quite small. All people should still keep a diary of signs and symptoms of vasodilation as well as records of what treatments have been taken. Any of the medications used to treat vasodilation could cause blood clotting to be activated. The activated clotting helps to prevent any blood clots because the clotting is not active until it feels that the blood needs to clot." - Anonymous Online Contributor
"Most Americans have vasodilation using a mean of 1.5 sprays/day, although fewer than half of those people use vasodilators more than one sputum time a day." - Anonymous Online Contributor
"The signs of vasodilation could be seen with the naked eye and include: pale, cool face, blue discoloration of the hands and feet, and red/yellow cheeks and nose. The signs of vasodilation can be seen with the naked eye as the redness and heat from the red skin can be seen by placing one's hand on an erythrocyte agglomeration. If one experiences symptoms such as dizziness, fainting, and weakness, one should immediately seek medical attention. The symptoms of vasodilation are not always present; therefore, there must be close and close observation. It is important to keep a history of symptoms and physical examination." - Anonymous Online Contributor
"Acetylcholine is known to induce bronchoconstriction; but a new idea is that this action may serve to open pulmonary arteries and capillary blood vessels in lungs which might result in improved exchange of oxygen and carbon dioxide, thus increasing the elimination of carbon dioxide on the lung surface which ultimately results in improved gas exchange. This effect may explain why people with COPD often hyperventilate, and why their symptoms improve on using inhaling a mixture of nitric oxide and xenon (NO2X)." - Anonymous Online Contributor
"There has not been any new discoveries for treating vasodilation. The most important thing is to learn the mechanism of vasodilation, in order to find treatments for vasodilation, which is a common complaint of many patients." - Anonymous Online Contributor
"The ACh test can show improvement in the symptoms of patients with vasovagal syncope, a medical condition which can mimic panic attacks. The test does not show any improvement in the severity of vasovagal syncope and does not show any better results than a placebo would have shown." - Anonymous Online Contributor
"While there is no evidence for a simple, heritable model to explain MHRV, a model that is more complex than familial susceptibility to cardiovascular disease is required." - Anonymous Online Contributor
"It has been shown that vasodilation with acetylcholine improves quality of life for people with severe peripheral arterial disease. With further research, this method could be a new and effective treatment for people with PAD." - Anonymous Online Contributor
"Results from a recent paper, a submaximal high dose of ACh resulted in a sustained peripheral vasoconstriction and mydriasis. No other major side-effects were observed. Further studies with larger numbers of patients are required to assess the possible clinical significance." - Anonymous Online Contributor