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Chemotherapy

Diet Variation for Environmental Exposures

Q: Does this investigation include elderly participants under 80 years of age?

This medical study is open to adults aged 21 and over, up until the age of 65.

Q: Am I able to enroll in this clinical investigation?

This investigation is searching for 7 individuals aged 21-65 who have experienced environmental exposures. To qualify, participants must abstain from consuming cruciferous vegetables, I3C or DIM supplements, smoked and cured meats or cheeses, as well as charcoal grilled food during the study period (gas grilling being an exception). Applicants should be in a generally good health condition with no major changes to their physical state since prior studies 8233 and 8554 if applicable. Female volunteers must either be postmenopausal or surgically sterilized so that there will not be any possible fetal exposure risks. Furthermore, they are encouraged to forego blood

Q: Are members of the public being sought for this experimental research?

Regrettably, the information posted on clinicaltrials.gov suggest that this research is no longer enrolling participants; it was initially published on January 24th 2019 and last updated almost three years ago. Nevertheless, 15 other trials are currently recruiting candidates to join their studies.

Phase < 1

Waitlist Available

Research Sponsored by Oregon State University

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Be older than 18 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up -7 days and 48 hours

Awards & highlights

Study Summary

This trial looked at the levels of a cancer-causing compound, benzo[a]pyrene, in the blood and urine of people who had just been exposed to it, after eating Brussels sprouts, and after taking a supplement containing DIM.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ -7 days and 48 hours

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~-7 days and 48 hours

This trial's timeline: 3 weeks for screening, Varies for treatment, and -7 days and 48 hours for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Plasma and urine 14C-BaP and 14C-BaP metabolite levels after oral dose

Secondary outcome measures

Area under plasma concentration of 14C-BaP versus time curve AUC

Metabolites of 14C-BaP in plasma

Metabolites of 14C-BaP in urine

+7 more

Trial Design

3Treatment groups

Experimental Treatment

Group I: DIM supplement before 50 ng doseExperimental Treatment1 Intervention

Subjects will consume 300 mg DIM supplement ( 2 capsules of BioResponse DIM® 150) each evening for 7 days prior to taking capsule containing 50 ng (5.4 nCi) [14C]-benzo[a]pyrene (BaP). A 300 mg DIM dose will be co-administrated with the 50 ng BaP dose

Group II: Brussels sprouts before 50 ng doseExperimental Treatment1 Intervention

Subjects will consume 50 g (about 1/2 cup) of lightly steamed Brussels sprouts each evening for 7 days prior to taking capsule containing 50 ng (5.4 nCi) [14C]-benzo[a]pyrene (BaP)

Group III: 50 ng doseExperimental Treatment1 Intervention

Capsule containing 50 ng (5.4 nCi) [14C]-benzo[a]pyrene (BaP)

Treatment

First Studied

Drug Approval Stage

How many patients have taken this drug

Brussels sprouts before 50 ng dose

2019

Completed Early Phase 1

~10

DIM supplement before 50 ng dose

2019

Completed Early Phase 1

~10

[14C]-benzo[a]pyrene

2018

Completed Early Phase 1

~20

Do I qualify?Apply below to find out

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Who is running the clinical trial?

Oregon State UniversityLead Sponsor

49 Previous Clinical Trials

8,374 Total Patients Enrolled

3 Trials studying Environmental Exposures

453 Patients Enrolled for Environmental Exposures

National Institute of Environmental Health Sciences (NIEHS)NIH

284 Previous Clinical Trials

1,232,730 Total Patients Enrolled

12 Trials studying Environmental Exposures

4,759 Patients Enrolled for Environmental Exposures

Lawrence Livermore National LaboratoryOTHER

5 Previous Clinical Trials

86 Total Patients Enrolled

2 Trials studying Environmental Exposures

13 Patients Enrolled for Environmental Exposures

Media Library

[14C]-benzo[a]pyrene (Chemotherapy) Clinical Trial Eligibility Overview. Trial Name: NCT03802721 — Phase < 1

Environmental Exposures Research Study Groups: Brussels sprouts before 50 ng dose, DIM supplement before 50 ng dose, 50 ng dose

Environmental Exposures Clinical Trial 2023: [14C]-benzo[a]pyrene Highlights & Side Effects. Trial Name: NCT03802721 — Phase < 1

[14C]-benzo[a]pyrene (Chemotherapy) 2023 Treatment Timeline for Medical Study. Trial Name: NCT03802721 — Phase < 1

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Does this investigation include elderly participants under 80 years of age?

"This medical study is open to adults aged 21 and over, up until the age of 65."

Answered by AI

Am I able to enroll in this clinical investigation?

"This investigation is searching for 7 individuals aged 21-65 who have experienced environmental exposures. To qualify, participants must abstain from consuming cruciferous vegetables, I3C or DIM supplements, smoked and cured meats or cheeses, as well as charcoal grilled food during the study period (gas grilling being an exception). Applicants should be in a generally good health condition with no major changes to their physical state since prior studies 8233 and 8554 if applicable. Female volunteers must either be postmenopausal or surgically sterilized so that there will not be any possible fetal exposure risks. Furthermore, they are encouraged to forego blood"

Answered by AI

Are members of the public being sought for this experimental research?

"Regrettably, the information posted on clinicaltrials.gov suggest that this research is no longer enrolling participants; it was initially published on January 24th 2019 and last updated almost three years ago. Nevertheless, 15 other trials are currently recruiting candidates to join their studies."

Answered by AI

Recent research and studies

clinicaltrials.govStudy

Pharmacokinetics of Benzo[a]Pyrene: Impact of Diet

David Williams 2019. "Pharmacokinetics of Benzo[a]Pyrene: Impact of Diet". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT03802721.