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Acute Pretreatment with Calcitriol for Cocaine Use Disorder

Phase < 1
Waitlist Available
Led By Marc Potenza, MD, PhD
Research Sponsored by Yale University
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Age 30-55 years
Positive urine toxicology screen for cocaine
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 150 minutes
Awards & highlights

Study Summary

This study is evaluating whether vitamin D might help people stop using cocaine.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~150 minutes
This trial's timeline: 3 weeks for screening, Varies for treatment, and 150 minutes for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Cocaine Self Administration Attempts
Cocaine Self Administration Infusions
Secondary outcome measures
Probabilistic Reward Task (PRT)
Probabilistic Selection Task (PST)
Subjective Effects of Cocaine / Visual Analog Scale (VAS)

Trial Design

2Treatment groups
Active Control
Placebo Group
Group I: Acute Pretreatment with CalcitriolActive Control1 Intervention
To explore the effects of acute pre-treatment with Calcitriol on attempts to self-administer and ultimate number of infusions/boluses of cocaine, in experienced, non treatment-seeking users of the drug
Group II: Acute Pretreatment with PlaceboPlacebo Group1 Intervention
To explore the effects of acute pre-treatment with placebo on attempts to self-administer and ultimate number of infusions/boluses of cocaine, in experienced, non treatment-seeking users of the drug

Find a Location

Who is running the clinical trial?

Yale UniversityLead Sponsor
1,848 Previous Clinical Trials
2,737,814 Total Patients Enrolled
Marc Potenza, MD, PhDPrincipal InvestigatorYale University
2 Previous Clinical Trials
24 Total Patients Enrolled

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Recent research and studies
clinicaltrials.govStudy
Vitamin D and Cocaine Administration
Marc Potenza 2019. "Vitamin D and Cocaine Administration". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT04826133.
~1 spots leftby Apr 2025
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