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What is Adempas
RiociguatThe Generic name of this drug
Treatment SummaryRiociguat (brand name Adempas) is a prescription drug used to treat pulmonary arterial hypertension (PAH) and chronic thromboembolic pulmonary hypertension (CTEPH). It works by increasing the activity of an enzyme called soluble guanylate cyclase. A 30-day supply of the drug costs $7,500.
Adempasis the brand name
Adempas Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Adempas
Riociguat
2013
5
Approved as Treatment by the FDA
Riociguat, also known as Adempas, is approved by the FDA for 2 uses like Pulmonary Arterial Hypertension and Chronic Thromboembolic Pulmonary Hypertension (CTEPH) .Pulmonary Arterial Hypertension
Helps manage Pulmonary Arterial Hypertension (PAH)
Chronic Thromboembolic Pulmonary Hypertension (CTEPH)
Helps manage Chronic Thromboembolic Pulmonary Hypertension (CTEPH)
Effectiveness
How Adempas works in the bodyRiociguat helps treat pulmonary hypertension by increasing the amount of a signaling molecule called cyclic guanosine monophosphate (cGMP). It works by activating an enzyme called soluble guanylate cyclase (sGC). This enzyme helps produce cGMP when it binds to nitric oxide, a molecule released by the body. Riociguat boosts this process in two ways: it stabilizes the bond between sGC and nitric oxide, and it directly stimulates sGC without nitric oxide. Both of these effects lead to more cGMP, which causes blood vessels to widen and reduce symptoms of
When to interrupt dosage
The recommended measure of Adempas is dependent upon the diagnosed condition. The amount of dosage fluctuates, contingent upon the technique of administration featured in the table beneath.Condition
Dosage
Administration
Pulmonary Arterial Hypertension
0.5 mg, , 1.5 mg, 2.0 mg, 1.0 mg, 2.5 mg
, Tablet, Oral, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral
Chronic Thromboembolic Pulmonary Hypertension (CTEPH)
0.5 mg, , 1.5 mg, 2.0 mg, 1.0 mg, 2.5 mg
, Tablet, Oral, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral
Warnings
Adempas has thirteen contraindications and should not be utilized in unison with the conditions found in the following table.Adempas ContraindicationsCondition
Risk Level
Notes
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Pulmonary Hypertension
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Common Adempas Drug Interactions
Drug Name
Risk Level
Description
Amifostine
Major
Riociguat may increase the hypotensive activities of Amifostine.
Brigatinib
Major
The metabolism of Brigatinib can be decreased when combined with Riociguat.
Cabazitaxel
Major
The metabolism of Cabazitaxel can be decreased when combined with Riociguat.
Enasidenib
Major
The metabolism of Enasidenib can be decreased when combined with Riociguat.
Erlotinib
Major
The metabolism of Erlotinib can be decreased when combined with Riociguat.
Adempas Toxicity & Overdose RiskPregnant women should not take Riociguat as it can harm the fetus. Women of reproductive age should verify they are not pregnant before beginning treatment, and should use effective birth control methods while taking it. Riociguat is only available under a special program called the Adempas Risk Evaluation and Mitigation Strategy.
Adempas Novel Uses: Which Conditions Have a Clinical Trial Featuring Adempas?
At present, 56 clinical trials are being conducted to assess the effectiveness of Adempas in mitigating Pulmonary Arterial Hypertension.Condition
Clinical Trials
Trial Phases
Pulmonary Arterial Hypertension
5 Actively Recruiting
Phase 1, Not Applicable, Phase 2
Chronic Thromboembolic Pulmonary Hypertension (CTEPH)
4 Actively Recruiting
Not Applicable, Phase 3, Phase 2
Adempas Reviews: What are patients saying about Adempas?
3.3Patient Review
12/7/2017 I've been on this medication for a while now, and from the beginning, it's given me stomach pain and upset. Recently, I've started bleeding from my gums and bowels. I don't feel unwell otherwise, but my oxygen levels haven't changed much either. I'll give it a few more months to see if there are any improvements.
3.3Patient Review
10/7/2014 I experienced dizziness on the first day of each dosage increase, up to a maximum of 2.5mg.
2.7Patient Review
7/28/2014 I have experienced extreme gastrointestinal issues, to the point where I had to increase my use of prilosec. I've also dealt with diarrhea and constipation, as well as bone pain and hair loss. My dermatologist believes that the hair loss may be a result of the combination of cuomadin and adempas; regardless, it is pretty extreme. I'm not sure that this treatment has improved my overall wellbeing when compared to the Tracleer/Adcirca combo.
1.7Patient Review
3/20/2018 I saw no improvement after two months of use. If anything, I felt worse; heartburn, nausea, and stomach pain were all daily occurrences. And the supposed increase in quality of life? Nowhere to be found.
1.7Patient Review
11/2/2021 I was on Adempas for almost 4 months. It never helped me past a .5 dosage, and it tore my stomach up. My breathing also got worse while I was taking the medication. My first 6 minute walk was easy before starting Adempas, but after starting the medication I struggled. The physician who prescribed me the drug ignored my concerns and refused to listen to me. I went to Mayo Clinic, where I was referred by the same physician. They took me off the medication immediately. I am currently 66 years old and was diagnosed in April 2020.
1.7Patient Review
8/22/2016 This treatment did not help me at all. I saw much better results with Adcirca and will be returning to that medication.
1.3Patient Review
3/4/2014 The side effects weren't worth it for me. I had diarrhea, nausea, headaches, and a stuffy nose.
Patient Q&A Section about adempas
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.How effective is Adempas?
"A study of 443 adults with PAH found that those taking Adempas were able to walk 98 feet further in a six-minute walk test than those not taking the drug after 12 weeks."
Answered by AI
What is Adempas drug used for?
"Adempas is approved to treat adults with persistent or recurrent chronic thromboembolic pulmonary hypertension that cannot be treated with surgery."
Answered by AI
Is Adempas generic?
"There is no version of the drug Adempas that is therapeutically equivalent in the United States. There may be some online pharmacies that sell counterfeit versions of the drug which may be unsafe."
Answered by AI
What kind of drug is Adempas?
"Adempas can help to lower blood pressure in the lungs, making it easier for the heart to pump blood around the body. It is used to treat a condition called chronic thromboembolic pulmonary hypertension, which can't be cured with surgery, or where surgery hasn't worked."
Answered by AI