HCC Clinical Trials
Here are the 6 most popular medical studies for hcc
CAR Inverse Agonist
Meclizine for Liver Cancer
This trial is testing whether meclizine, which is typically used for vertigo and motion sickness, could also have therapeutic benefits for patients with hepatocellular carcinoma. The effects of meclizine will be analyzed by measuring the messenger RNA levels of certain genes.
Checkpoint Inhibitor
Durvalumab + Tremelimumab for Liver Cancer
This trial is testing a new cancer treatment that consists of two drugs, Durvalumab and Tremelimumab. The treatment is given before surgery to remove the tumor and then given again after surgery. The trial is testing if this treatment is safe and if it changes the tumor microenvironment. 28 patients are expected to enroll at three sites.
Popular filter options for hcc trials
Liver Cancer Clinical Trials
View 78 Liver Cancer medical studies.
Chemotherapy
Irinotecan +2 More for Liver Cancer
This trial aims to test a new combination of three drugs for treating liver cancer. The study will determine safe doses of the drugs and evaluate their effectiveness in improving patient outcomes compared to the current standard treatment.
HCC Clinical Trials
View 29 HCC medical studies.
Tyrosine Kinase Inhibitor
Regorafenib + Pembrolizumab vs. Loco-Regional Therapy for Liver Cancer
This trial evaluates a new treatment for people with liver cancer, comparing regorafenib and pembrolizumab to existing treatments. 496 patients will be studied worldwide.
Metastatic Hepatocellular Carcinoma Clinical Trials
View 98 metastatic hepatocellular carcinoma medical studies.
Monoclonal Antibodies
Triple-Drug Combo for Liver Cancer
This trial will compare the safety and effectiveness of a three-drug combo of nivolumab, relatlimab, and bevacizumab versus a two-drug combo of just nivolumab and bevacizumab in people with HCC that has not yet been treated.
Phase 3 Hepatocellular Carcinoma Clinical Trials
View 98 phase 3 hepatocellular carcinoma medical studies.
Tyrosine Kinase Inhibitor
Regorafenib + Pembrolizumab vs. Loco-Regional Therapy for Liver Cancer
This trial evaluates a new treatment for people with liver cancer, comparing regorafenib and pembrolizumab to existing treatments. 496 patients will be studied worldwide.
Statin
Simvastatin for Liver Cirrhosis
This trial will test whether simvastatin can lower the risk of hepatic decompensation in people with compensated cirrhosis. It will also explore how changes in genes effect the safety and effectiveness of using statins and how the use of statins affects quality of life.
Hepatocellular Carcinoma Clinical Trials With No Placebo
View 98 hepatocellular carcinoma medical studies that do not have a placebo group.
Tyrosine Kinase Inhibitor
Regorafenib + Pembrolizumab vs. Loco-Regional Therapy for Liver Cancer
This trial evaluates a new treatment for people with liver cancer, comparing regorafenib and pembrolizumab to existing treatments. 496 patients will be studied worldwide.
View More Hcc Trials
See another 74 medical studies focused on hcc.
Frequently Asked Questions
Introduction to hcc
What are the top hospitals conducting hcc research?
In the battle against hepatocellular carcinoma (HCC), some of the top hospitals specializing in clinical trials are making remarkable strides. Memorial Sloan Kettering Cancer Center, located in the vibrant city of New york, has emerged as a frontrunner with five active HCC trials and a total of 20 completed studies dedicated to this complex condition. Their first recorded trial on HCC dates back to 2007, highlighting their long-standing commitment to improving outcomes for patients.
Heading down south to Houston, we find two renowned medical centers making significant contributions. M D Anderson Cancer Center leads the charge with five ongoing HCC trials and an impressive history of 27 completed studies since their initial trial in 2002. Meanwhile, MD Anderson Cancer Center is also actively engaged in four current HCC trials, having conducted a total of 13 research projects since embarking on their first trial in 2007.
Expanding our exploration across states brings us to City of Hope in Duarte where researchers are diligently working on four active HCC trials while building upon their previous thirteen investigations that began back in 2002. Finally, at Dana Farber Cancer Institute situated within Boston's prestigious medical landscape, experts are currently conducting four clinical trials focused on HCC treatment options as part of their commitment towards these cases which they initiated from launching its debut investigation into this field only seven years ago during2014
These esteemed institutions collectively represent hope for those affected by hepatocellular carcinoma - offering cutting-edge treatments and advancements through rigorous research efforts. With every trial undertaken and breakthrough achieved at these leading hospitals comes renewed optimism for patients fighting against this aggressive form of liver cancer
Which are the best cities for hcc clinical trials?
When it comes to HCC clinical trials, several cities emerge as frontrunners in research and development. New york City leads the pack with 35 active trials investigating treatments like Nivolumab, SRF388, and Pembrolizumab. Houston closely follows with 31 ongoing studies examining interventions such as Meclizine Oral Tablet, cabozantinib, and Resin microspheres containing yttrium-90 (Y-90). Los Angeles boasts 25 active trials focused on options like Nivolumab, Telatinib, and Pembrolizumab. Boston also plays a significant role with 23 ongoing trials exploring Durvalumab, Nivolumab, lenvatinib,and others. Lastly,Dallas hosts 19 active trials studying therapies including Nivolumab,Dose Expansion Part: CRC Subpart: E7386 + Lenvatinib,and Arm3:Livmoniplimab Dose B+ Budigalimab.These cities serve as hubs of innovation for individuals seeking cutting-edge HCC clinical trial opportunities that drive progress towards improved outcomes.
Which are the top treatments for hcc being explored in clinical trials?
Clinical trials are paving the way for advancements in treating hepatocellular carcinoma (HCC). Among the top treatments being explored are:
- Nivolumab: Currently involved in six active HCC trials, with a total of 49 all-time trials since its introduction in 2012.
- Pembrolizumab: Showing promise with five ongoing clinical trials for HCC and a solid track record of 38 all-time trials since 2016.
- Atezolizumab: Making strides in four ongoing HCC trials, joining the field in 2018 after accumulating 34 previous clinical trials.
- Durvalumab: Engaged in three active HCC studies and having debuted on the scene back in 2015 with a cumulative count of 30 clinical trials.
- SRF388: Emerging as a new player with two current HCC trials and two past investigations following its listing just last year.
These treatments represent significant progress, offering renewed hope to patients battling hepatocellular carcinoma.
What are the most recent clinical trials for hcc?
Recent clinical trials have brought promising advancements in the treatment of hepatocellular carcinoma (HCC). One notable study is focused on Livmoniplimab and Budigalimab, which are being evaluated as a combination therapy for HCC patients in Arm 3 of a Phase 2 trial. Another trial investigates the potential benefits of Tegavivint as a single agent dosing regimen for HCC. Additionally, there is ongoing research examining Transarterial Embolization with Hydroxychloroquine and Part B Dose Expansion Combination treatments for HCC. These studies provide hope for improved outcomes and expanded therapeutic options in the fight against HCC.
What hcc clinical trials were recently completed?
Numerous clinical trials targeting hepatocellular carcinoma (HCC) have recently concluded, showcasing advancements in treatment strategies for this aggressive liver cancer. Notably, a trial sponsored by Hoffmann-La Roche investigated the efficacy of RO7119929 and wrapped up in July 2020. Additionally, an innovative study led by Ajit H. Goenka, MD explored the potential of 68Ga-PSMA-11 PET/MRI and reached completion in June 2019. Alongside these efforts were investigations into nivolumab sponsored by the National Cancer Institute (NCI), GLYCAR T cells conducted at Baylor College of Medicine, [68Ga]DOTATATE-PET/MRI carried out at the University of Alabama at Birmingham, among other remarkable initiatives from esteemed institutions like Bayer and Johns Hopkins' Sidney Kimmel Comprehensive Cancer Center. These milestones highlight ongoing dedication to combating HCC through cutting-edge research.