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The University of Texas Health Science Center at Houston

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Houston, Texas 77030

Global Leader in Stroke

Global Leader in Premature Birth

Conducts research for I Am A Healthy Volunteer

Conducts research for Coronavirus

Conducts research for Newborns

942 reported clinical trials

138 medical researchers

Photo of The University of Texas Health Science Center at Houston in HoustonPhoto of The University of Texas Health Science Center at Houston in HoustonPhoto of The University of Texas Health Science Center at Houston in Houston

Summary

The University of Texas Health Science Center at Houston is a medical facility located in Houston, Texas. This center is recognized for care of Stroke, Premature Birth, I Am A Healthy Volunteer, Coronavirus, Newborns and other specialties. The University of Texas Health Science Center at Houston is involved with conducting 942 clinical trials across 1,216 conditions. There are 138 research doctors associated with this hospital, such as Sean Savitz, Modupe Idowu, MD, Hope Northrup, and Jay-Jiguang Zhu, MD.

Area of expertise

1

Stroke

Global Leader

The University of Texas Health Science Center at Houston has run 52 trials for Stroke. Some of their research focus areas include:

anticoagulant
48 hours
ACTA2 positive
2

Premature Birth

Global Leader

The University of Texas Health Science Center at Houston has run 41 trials for Premature Birth.

Top PIs

Clinical Trials running at The University of Texas Health Science Center at Houston

Huntington's Disease

Stroke

Prostate Cancer

Premature Birth

Pulmonary Embolism

Arteriovenous Fistula

Frontotemporal Dementia

Diabetes

Cervical Cancer

Pancreatic Cancer

Image of trial facility.

Neurodevelopment

for Huntington's Disease

Huntington's Disease (HD) is an autosomal dominant disease manifested in a triad of cognitive, psychiatric, and motor signs and symptoms. HD is caused by a triplet repeat (CAG)expansion in the gene Huntingtin (HTT). This disease has classically been conceptualized as a neurodegenerative disease. However, recent evidence suggests that abnormal brain development may play an important role in the etiology of HD. Huntingtin (HTT)is expressed during development and through life. In animal studies, the HTT gene has been shown to be vital for brain development. This suggests that a mutant form of HTT (gene-expanded or CAG repeats of 40 and above) would affect normal brain development. In addition, studies in adults who are gene-expanded for HD, but have not yet manifested the illness, (pre-HD subjects) have significant changes in the structure of their brain, even up to 20 years before onset of clinical diagnosis. How far back these changes are evident is unknown. One possibility is that these brain changes are present throughout life, due to changes in brain development,though initially associated with only subtle functional abnormalities. In an effort to better understand the developmental aspects of this brain disease, the current study proposes to evaluate brain structure and function in children, adolescents, and young adults (ages 6-30) who are at risk for developing HD - those who have a parent or grandparent with HD. Brain structure will be evaluating using Magnetic Resonance Imaging (MRI) with quantitative measures of the entire brain, cerebral cortex, as well as white matter integrity via Diffusion Tensor Imaging. Brain function will be assessed by cognitive tests, behavioral assessment, and physical and neurologic evaluation. Subjects that are gene-expanded (GE) will be compared to subjects who are gene non-expanded (GNE). Changes in brain structure and/or function in the GE group compared to the GNE group would lend support to the notion that this disease has an important developmental component.

Recruiting

1 award

N/A

3 criteria

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Brain Structure Assessment

for Juvenile-onset Huntington's Disease

The goal of this observational study is to learn about brain development in Juvenile-onset Huntington's Disease (JoHD). The main questions it aims to answer are: * Is brain development different in JoHD than Adult-onset Huntington's Disease (AoHD)? * Can reliable biomarkers for JoHD be found in brain structure and function? Participants will be asked to complete cognitive tests, behavioral assessments, physical and neurologic evaluation, and MRI. Data collected will be compared to populations who are at-risk for HD and who have been diagnosed with HD as adults.

Recruiting

1 award

N/A

2 criteria

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Registry Study

for Huntington's Disease

Enroll-HD is a longitudinal, observational, multinational study that integrates two former Huntington's disease (HD) registries-REGISTRY in Europe, and COHORT in North America and Australasia-while also expanding to include sites in Latin America. More than 30,000 participants have now enrolled into the study. With annual assessments and no end date, Enroll-HD has built a large and rich database of longitudinal clinical data and biospecimens that form the basis for studies developing tools and biomarkers for progression and prognosis, identifying clinically-relevant phenotypic characteristics, and establishing clearly defined endpoints for interventional studies. Periodic cuts of the database are now available to any interested researcher to use in their research - visit www.enroll-hd.org/for-researchers/access-data/ to learn more.

Recruiting

1 award

N/A

9 criteria

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