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Baylor College of Medicine

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Houston, Texas 77030

Global Leader in Breast Cancer

Global Leader in Flu

Conducts research for Ulcerative Colitis

Conducts research for Parkinson's Disease

Conducts research for HIV Infection

1378 reported clinical trials

106 medical researchers

Photo of Baylor College of Medicine in HoustonPhoto of Baylor College of Medicine in Houston

Summary

Baylor College of Medicine is a medical facility located in Houston, Texas. This center is recognized for care of Breast Cancer, Flu, Ulcerative Colitis, Parkinson's Disease, HIV Infection and other specialties. Baylor College of Medicine is involved with conducting 1,378 clinical trials across 1,521 conditions. There are 106 research doctors associated with this hospital, such as Jennifer Foster, MD, Patricia Baxter, MD, Mohamed O. Othman, MD, and Carlos Ramos, MD.

Area of expertise

1

Breast Cancer

Global Leader

Baylor College of Medicine has run 55 trials for Breast Cancer. Some of their research focus areas include:

Stage IV
ER positive
HER2 positive
2

Flu

Global Leader

Baylor College of Medicine has run 49 trials for Flu.

Top PIs

Clinical Trials running at Baylor College of Medicine

Ovarian Cancer

Depression

Liver Cancer

Breast Cancer

Cystic Fibrosis

Heart Failure

Hepatocellular Carcinoma

Atrial Fibrillation

Lazy Eye

Retinitis Pigmentosa

Image of trial facility.

Olvi-Vec + Chemotherapy

for Ovarian Cancer

The OnPrime study is a multi-center, randomized open-label phase 3 study evaluating the safety and efficacy of Olvi-Vec followed by platinum-doublet chemotherapy and bevacizumab compared to the Active Comparator Arm with Physician's Choice of chemotherapy and bevacizumab in women diagnosed with platinum-resistant/refractory ovarian cancer (includes fallopian tube cancer and primary peritoneal cancer). This Phase III trial builds on the efficacy and safety data reported in the previous Phase II VIRO-15 trial with promising objective response rate and progression-free survival observed in heavily pre-treated patients with platinum-resistant/refractory ovarian cancer. The phase II results also showed that the intra-peritoneal route of delivery was efficient in generating tumor cell killing and immune activation, and led to clinical reversal of platinum-resistance or refractoriness in this difficult-to-treat patient population.

Recruiting

2 awards

Phase 3

7 criteria

Image of trial facility.

Heated Chemotherapy + Niraparib

for Ovarian Cancer

Patients will be registered prior to, during or at the completion of neoadjuvant chemotherapy given per standard institutional guidelines +/- bevacizumab on Day 1 every 21 days for 3-4 cycles. Registered patients who progress during neoadjuvant chemotherapy will not be eligible for iCRS and will be removed from the study. Following completion of neoadjuvant chemotherapy, interval cytoreductive surgery (iCRS) will be performed in the usual fashion in both arms. Patients will be randomized at the time of iCRS (iCRS must achieve no gross residual disease or no disease \>1.0 cm in largest diameter) to receive HIPEC or no HIPEC. Patients randomized to HIPEC Arm will receive a single dose of cisplatin (100mg/m2 IP over 90 minutes at 42 C) as HIPEC. After postoperative recovery patients will receive standard post-operative platinum-based combination chemotherapy. Patients randomized to surgery only (No HIPEC Arm) will receive postoperative standard chemotherapy after recovery from surgery. Both groups will receive an additional 2-3 cycles of platinum-based combination chemotherapy per standard institutional guidelines +/- bevacizumab for a maximum total of 6 cycles of chemotherapy (neoadjuvant plus post-operative cycles) followed by niraparib individualized dosing +/- bevacizumab until progression or 36 months (if no evidence of disease).

Recruiting

2 awards

Phase 3

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