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Boston Children's Hospital
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Boston, Massachusetts 02115
Global Leader in Cystic Fibrosis
Global Leader in Congenital Heart Diseases
Conducts research for Sickle Cell Disease
Conducts research for Epilepsy
Conducts research for Congenital Heart Disease
1223 reported clinical trials
124 medical researchers
Summary
Boston Children's Hospital is a medical facility located in Boston, Massachusetts. This center is recognized for care of Cystic Fibrosis, Congenital Heart Diseases, Sickle Cell Disease, Epilepsy, Congenital Heart Disease and other specialties. Boston Children's Hospital is involved with conducting 1,223 clinical trials across 1,622 conditions. There are 124 research doctors associated with this hospital, such as Susan Chi, MD, Dr. David Brown, Katherine A. Janeway, and Steven G. DuBois, MD, MS.
Area of expertise
Cystic Fibrosis
Boston Children's Hospital has run 99 trials for Cystic Fibrosis. Some of their research focus areas include:
Congenital Heart Diseases
Boston Children's Hospital has run 58 trials for Congenital Heart Diseases.
Top PIs
Susan Chi, MD
Dana-Farber Cancer Institute
6 years of reported clinical research
Dr. David Brown
Retina Consultants of Texas
2 years of reported clinical research
Katherine A. Janeway
Dana-Farber Cancer Institute
8 years of reported clinical research
Steven G. DuBois, MD, MS
Dana-Farber Cancer Institute
4 years of reported clinical research
Clinical Trials running at Boston Children's Hospital
Crohn's Disease
Deletion Syndrome
Duplication Syndrome
Rett Syndrome
Epilepsy
Ulcerative Colitis
Intellectual Disability
Inflammatory Bowel Disease
Genetic Disorders
Bronchopulmonary Dysplasia
Anti-TNF Therapy
for Crohn's Disease in Children
Crohn's disease (CD) is a condition that causes inflammation (swelling, redness) of the lining and wall of the small intestine, large intestine, or both. CD may be associated with abdominal cramps/pain, diarrhea, blood in the stool, weight loss, or delayed growth in children. While the exact cause of CD is not certain it is thought that the immune system located in the intestine reacts abnormally to the large number of bacteria contained there. The investigators think that diet, exposure to antibiotics early in life, and having a family history of CD puts people at increased risk for developing CD. In order to decrease the inflammation doctors use what is called biologic therapy with anti-TNF molecules that can be given through an intravenous or shots. TNF is a chemical made by white blood cells that is involved in inflammation. When this type of treatment is given early after diagnosis it is more effective than when it is given later. The investigators have learned that it is important to give the optimum (ideal) amount of this medicine guided by certain blood tests. The investigators also know that not everyone responds to this therapy but do not understand the reasons for this variability between people. The CAMEO study has been started to help understand what factors are important in determining whether a child with CD completely heals the inflammation after anti-TNF therapy. The investigators will do that by measuring certain markers of inflammation in the blood and stool and by looking at a person's genes (DNA) and how inflammation is controlled in the intestine. These inflammation tests will be done before, during, and after one year of anti-TNF therapy. The investigators will determine how much healing has taken place by comparing the results of the colonoscopy and a special type of MRI that are both done before anti-TNF and then again one year later. The goal in treating CD is to heal both the lining and the wall of the intestine. Children ages 6-17 years who are thought to have CD and are about to undergo their diagnostic colonoscopy are eligible to be enrolled. If they are found to indeed have CD and start an anti-TNF medicine within 6 months they can continue in the study. There are no increased risks of participating in this study beyond those normally associated with having CD and its treatment. By better understanding why the bowel does or does not heal, doctors will be better able to provide personalized care.
Recruiting
3 awards
Phase 4
7 criteria
Vedolizumab
for Ulcerative Colitis and Crohn's Disease
The study is an extension of two parent studies (MLN0002-3024 \[NCT04779307\] and MLN0002-3025 \[NCT04779320\]). Participants must have participated in one of the previous studies. The purpose of this study is to collect the long-term safety of vedolizumab in children with UC or CD.
Recruiting
3 awards
Phase 3
Guselkumab
for Pediatric Crohn's Disease
This trial tests guselkumab, an anti-inflammatory medication, on children with Crohn's Disease who initially responded well to it. The goal is to see if the benefits last over several months by reducing immune system activity. Guselkumab has shown effectiveness in treating moderate-to-severe psoriasis and psoriatic arthritis.
Recruiting
2 awards
Phase 3
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Frequently asked questions
What kind of research happens at Boston Children's Hospital?
Boston Children's Hospital is a medical facility located in Boston, Massachusetts. This center is recognized for care of Cystic Fibrosis, Congenital Heart Diseases, Sickle Cell Disease, Epilepsy, Congenital Heart Disease and other specialties. Boston Children's Hospital is involved with conducting 1,223 clinical trials across 1,622 conditions. There are 124 research doctors associated with this hospital, such as Susan Chi, MD, Dr. David Brown, Katherine A. Janeway, and Steven G. DuBois, MD, MS.
Where is Boston Children's Hospital located?
**Directions to Boston Children's Hospital:** - **By Public Transit:** Take the Green Line "D" train to the Longwood Medical Area stop. - **By Car:** Take the Massachusetts Turnpike (I-90) to Exit 22 at Copley Square/Prudential. Follow signs to Huntington Avenue and then to Longwood Avenue.
Who should I call to ask about financial aid or insurance network?
**Boston Children's Hospital Financial Assistance and Insurance Contact Information:** - **General Inquiries:** For questions related to financial assistance, billing, payment plans, and insurance matters, please call **617-355-3397**. - **Financial Assistance Applications:** For specific questions regarding financial assistance applications, contact the Financial Counseling Unit of the Patient Financial Services Department at **300 Longwood Avenue, Boston, MA, 02115**, or call **(617) 355-7201**.
What insurance does Boston Children's Hospital accept?
Boston Children's Hospital accepts a variety of insurance plans, including but not limited to: 1. Aetna 2. Blue Cross Blue Shield of Massachusetts (all products) 3. BMC Well Sense with Boston Children Hosp ACO 4. Children's Medical Security Plan 5. Allways Health Partners Commercial Plan 6. Blue Benefit's Administrators 7. Cigna 8. Fallon 9. Harvard Pilgrim Healthcare 10. United Healthcare (HMO, PPO, POS & Medicare) 11. UnitedHealthcare – Passport 12. UnitedHealthcare – Choice/Choice Plus 13. United Empire Plan Please verify your insurance coverage directly with the hospital or healthcare provider before receiving medical services.
What awards or recognition has Boston Children's Hospital received?
Boston Children's Hospital, located in Boston, Massachusetts, is the world's largest and most active pediatric research enterprise with $518 million in annual research funding. It boasts over 1,000,000 square feet of state-of-the-art laboratory space. The hospital's distinguished research community includes 13 members of the National Academy of Sciences, 28 members of the National Academy of Medicine, and four Nobel Prize winners.
Unbiased Results
We believe in providing patients with all the options.
Your Data Stays Your Data
We only share your information with the clinical trials you're trying to access.
Verified Trials Only
All of our trials are run by licensed doctors, researchers, and healthcare companies.
Unbiased Results
We believe in providing patients with all the options.
Your Data Stays Your Data
We only share your information with the clinical trials you're trying to access.
Verified Trials Only
All of our trials are run by licensed doctors, researchers, and healthcare companies.