Provider Training and Patient Education for HIV Prevention
(MOST:PrEP Trial)
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial aims to identify the best methods to increase PrEP (pre-exposure prophylaxis) prescriptions for HIV prevention in primary care settings. Researchers are testing various tools and strategies, such as provider training and patient education videos, to determine the most effective approach. These tools include a Best Practice Alert, computer-based simulation training for providers, an HIV Risk Assessment, and a PrEP Informational Video. Suitable participants for this trial include those visiting a Henry Ford primary care clinic who meet the criteria for starting PrEP. The trial focuses on improving prescription rates among groups less likely to receive PrEP, aiming to understand and reduce disparities in access. As an unphased trial, this study provides an opportunity to contribute to innovative strategies that could enhance healthcare access and equity.
Do I need to stop my current medications to join the trial?
The trial protocol does not specify whether you need to stop taking your current medications.
What prior data suggests that this protocol is safe for HIV prevention?
Research shows that the methods used in this study are generally safe and well-tolerated. Here is a breakdown:
1. **Best Practice Alert**: Studies have found that electronic alerts in medical records are safe. These alerts remind doctors to consider certain treatments, like HIV prevention, without harming patients.
2. **Computer-based Simulation Training for Providers**: Research indicates that computer-based training safely enhances healthcare providers' skills. This training functions like an interactive game that educates about HIV prevention.
3. **HIV Risk Assessment**: Research shows that risk assessments are commonly used in healthcare and are safe. They help identify individuals who might benefit from preventive measures like PrEP (pre-exposure prophylaxis).
4. **PrEP Informational Video**: Videos that provide information about PrEP safely educate patients. They explain how PrEP can help prevent HIV.
All these methods focus on education and awareness, with no reports of negative effects. They aim to improve understanding and health outcomes without compromising patient safety.12345Why are researchers excited about this trial?
Researchers are excited about this trial because it focuses on enhancing HIV prevention through provider training and patient education. Unlike traditional methods that primarily rely on medication, this approach uses a combination of techniques like computer-based simulations for healthcare providers and educational videos for patients about PrEP (pre-exposure prophylaxis). The goal is to improve risk assessment and communication between providers and patients, which could lead to better prevention strategies and increased PrEP uptake. By exploring various combinations of training and informational tools, the trial aims to identify the most effective ways to empower both providers and patients in preventing HIV.
What evidence suggests that this trial's treatments could be effective for increasing PrEP prescriptions?
Research has shown that PrEP (pre-exposure prophylaxis) effectively prevents HIV, reducing the risk of transmission from sex by about 99% when taken as directed. This trial tests various strategies to enhance PrEP uptake. One arm trains healthcare providers using computers, which studies have found improves their knowledge about HIV prevention and may lead to more PrEP prescriptions. Another arm includes automated alerts in healthcare settings, which significantly increase the number of HIV tests, helping identify more people who could benefit from PrEP. Assessing patient risk, a focus of another trial arm, effectively identifies individuals at higher risk for HIV, facilitating PrEP provision to those who need it most. Additionally, informational videos about PrEP, part of a separate trial arm, can improve understanding and acceptance of this preventive method. Together, these strategies, tested in different trial arms, can help increase PrEP use, especially in higher-risk groups.678910
Who Is on the Research Team?
Elizabeth Lockhart, PhD
Principal Investigator
Henry Ford Health
Are You a Good Fit for This Trial?
This trial is for primary care providers and patients at Henry Ford Health System. Providers must be over 18, able to prescribe in Michigan, and work at HFH. Patients also need to be over 18, have an EHR account, see a HFH provider during the study, and meet criteria for PrEP but not already be on it or HIV positive.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Intervention Feedback
Feedback generated on context-specific factors for intervention component delivery via focus groups with providers and patients
Optimization Trial
Testing of four intervention components in an optimization trial with 16 conditions implemented at 32 clinics
Implementation Feedback
Feedback generated on factors affecting implementation via semi-structured interviews with providers and patients
Follow-up
Participants are monitored for safety and effectiveness after intervention
What Are the Treatments Tested in This Trial?
Interventions
- Best Practice Alert
- Computer-based simulation training for providers
- HIV Risk Assessment
- PrEP Informational Video
Trial Overview
The trial tests how effective different interventions are in increasing new PrEP prescriptions in primary care. Interventions include alerts for providers and training simulations, as well as risk assessments and informational videos about PrEP for patients. The goal is to find efficient ways to prevent HIV.
How Is the Trial Designed?
16
Treatment groups
Experimental Treatment
Active Control
Patient PrEP Video only
Provider Training, Patient Risk Assessment, and Patient PrEP Video
Provider Training, Best Practice Alert, and Patient PrEP Video
Provider Training, Best Practice Alert, and Patient Risk Assessment
Provider Training, Best Practice Alert, Patient Risk Assessment, and Patient PrEP Video
Provider Training and Patient PrEP Video
Provider Training and Patient Risk Assessment
Provider Training and Best Practice Alert
Provider Training
Patient Risk Assessment and Patient PrEP Video
Patient Risk Assessment only
Best Practice Alert, Patient Risk Assessment, and Patient PrEP Video
Best Practice Alert and Patient PrEP Video
Best Practice Alert and Patient Risk Assessment
Best Practice Alert only
No intervention
Find a Clinic Near You
Who Is Running the Clinical Trial?
Henry Ford Health System
Lead Sponsor
New York University
Collaborator
University of South Florida
Collaborator
Citations
An automated best practice advisory increases both routine ...
After implementation, HIV testing increased 242%, from 2,851 tests to 9,757, and syphilis testing increased 326%, from 2,191 tests to 9,330. The proportion of ...
Effect of an Electronic Alert on Targeted HIV Testing ...
The positive test result rate increased from 0.02% to 0.04% (p < 0.001). During the postimplementation period, fewer HIV-infected patients had a ...
An automated best practice advisory increases both routine ...
After implementation, HIV testing increased 242%, from 2,851 tests to 9,757, and syphilis testing increased 326%, from 2,191 tests to 9,330. The proportion of ...
National HIV Prevention and Care Objectives | HIV Data
In 2022, over 80% of people with diagnosed HIV were linked to care within one month of diagnosis. Only 76% had received some care, 54% were ...
Implementing HIV prevention in the emergency department
This was a mixed-methods, type 3 hybrid implementation effectiveness study of seven California EDs that integrated HPS for HIV negative patients.
6.
viivconnect.com
viivconnect.com/content/dam/cf-viiv/viivconnect-v4/master/pdf/EHR_Guide_for_Creating_Alerts_to_Identify_Patients_Who_May_Be_Appropriate_for_APRETUDE.pdfEHR Guide for Creating Alerts to Identify Patients Who May ...
ViiV has created this guide to assist HCPs in identifying patients who may be at risk for. HIV and may be appropriate for APRETUDE (cabotegravir). Alerts ...
Designing an electronic medical record alert to identify ...
We created an EMR alert using readily available data elements to identify hospitalised people with HIV (PWH) to facilitate a quality improvement study.
8.
lgbtqiahealtheducation.org
lgbtqiahealtheducation.org/wp-content/uploads/HIV-Best-Practices-Final.pdfBEST PRACTICES IN HIV PREVENTION:
These data suggest that patients with. STIs, and particularly syphilis, are prime can- didates for intensive HIV prevention efforts. However, as with HIV ...
HIV Compendium of Best Practices
The Compendium is a searchable collection of best practices for HIV prevention designed to inform policy decisions, guidelines, program implementation, and ...
10.
clinicalinfo.hiv.gov
clinicalinfo.hiv.gov/en/guidelines/hiv-clinical-guidelines-adult-and-adolescent-arv/adherence-continuum-careAdherence to the Continuum of Care | NIH
In addition, preliminary data from a randomized clinical trial suggest that LA CAB/RPV may be safe and effective among people without viral ...
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