Provider Training and Patient Education for HIV Prevention

(MOST:PrEP Trial)

Age: 18+
Sex: Any
Trial Phase: Academic
Sponsor: Henry Ford Health System
No Placebo GroupAll trial participants will receive the active study treatment (no placebo)

What You Need to Know Before You Apply

What is the purpose of this trial?

This trial aims to identify the best methods to increase PrEP (pre-exposure prophylaxis) prescriptions for HIV prevention in primary care settings. Researchers are testing various tools and strategies, such as provider training and patient education videos, to determine the most effective approach. These tools include a Best Practice Alert, computer-based simulation training for providers, an HIV Risk Assessment, and a PrEP Informational Video. Suitable participants for this trial include those visiting a Henry Ford primary care clinic who meet the criteria for starting PrEP. The trial focuses on improving prescription rates among groups less likely to receive PrEP, aiming to understand and reduce disparities in access. As an unphased trial, this study provides an opportunity to contribute to innovative strategies that could enhance healthcare access and equity.

Do I need to stop my current medications to join the trial?

The trial protocol does not specify whether you need to stop taking your current medications.

What prior data suggests that this protocol is safe for HIV prevention?

Research shows that the methods used in this study are generally safe and well-tolerated. Here is a breakdown:

1. **Best Practice Alert**: Studies have found that electronic alerts in medical records are safe. These alerts remind doctors to consider certain treatments, like HIV prevention, without harming patients.

2. **Computer-based Simulation Training for Providers**: Research indicates that computer-based training safely enhances healthcare providers' skills. This training functions like an interactive game that educates about HIV prevention.

3. **HIV Risk Assessment**: Research shows that risk assessments are commonly used in healthcare and are safe. They help identify individuals who might benefit from preventive measures like PrEP (pre-exposure prophylaxis).

4. **PrEP Informational Video**: Videos that provide information about PrEP safely educate patients. They explain how PrEP can help prevent HIV.

All these methods focus on education and awareness, with no reports of negative effects. They aim to improve understanding and health outcomes without compromising patient safety.12345

Why are researchers excited about this trial?

Researchers are excited about this trial because it focuses on enhancing HIV prevention through provider training and patient education. Unlike traditional methods that primarily rely on medication, this approach uses a combination of techniques like computer-based simulations for healthcare providers and educational videos for patients about PrEP (pre-exposure prophylaxis). The goal is to improve risk assessment and communication between providers and patients, which could lead to better prevention strategies and increased PrEP uptake. By exploring various combinations of training and informational tools, the trial aims to identify the most effective ways to empower both providers and patients in preventing HIV.

What evidence suggests that this trial's treatments could be effective for increasing PrEP prescriptions?

Research has shown that PrEP (pre-exposure prophylaxis) effectively prevents HIV, reducing the risk of transmission from sex by about 99% when taken as directed. This trial tests various strategies to enhance PrEP uptake. One arm trains healthcare providers using computers, which studies have found improves their knowledge about HIV prevention and may lead to more PrEP prescriptions. Another arm includes automated alerts in healthcare settings, which significantly increase the number of HIV tests, helping identify more people who could benefit from PrEP. Assessing patient risk, a focus of another trial arm, effectively identifies individuals at higher risk for HIV, facilitating PrEP provision to those who need it most. Additionally, informational videos about PrEP, part of a separate trial arm, can improve understanding and acceptance of this preventive method. Together, these strategies, tested in different trial arms, can help increase PrEP use, especially in higher-risk groups.678910

Who Is on the Research Team?

EL

Elizabeth Lockhart, PhD

Principal Investigator

Henry Ford Health

Are You a Good Fit for This Trial?

This trial is for primary care providers and patients at Henry Ford Health System. Providers must be over 18, able to prescribe in Michigan, and work at HFH. Patients also need to be over 18, have an EHR account, see a HFH provider during the study, and meet criteria for PrEP but not already be on it or HIV positive.

Inclusion Criteria

Patient: meet the indications for PrEP
Patient: have an appointment with a Henry Ford primary care clinic during the study period
Patient: have an EHR account
See 2 more

Exclusion Criteria

Provider: not a HFH primary care provider
Provider: does not have prescribing privileges in the state of Michigan
I am currently taking medication to prevent HIV.
See 1 more

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Intervention Feedback

Feedback generated on context-specific factors for intervention component delivery via focus groups with providers and patients

4 weeks
Focus groups with providers (n=15) and patients (n=30)

Optimization Trial

Testing of four intervention components in an optimization trial with 16 conditions implemented at 32 clinics

6 months

Implementation Feedback

Feedback generated on factors affecting implementation via semi-structured interviews with providers and patients

4 weeks
Interviews with providers (n=30) and patients (n=30)

Follow-up

Participants are monitored for safety and effectiveness after intervention

6 months

What Are the Treatments Tested in This Trial?

Interventions

  • Best Practice Alert
  • Computer-based simulation training for providers
  • HIV Risk Assessment
  • PrEP Informational Video
Trial Overview The trial tests how effective different interventions are in increasing new PrEP prescriptions in primary care. Interventions include alerts for providers and training simulations, as well as risk assessments and informational videos about PrEP for patients. The goal is to find efficient ways to prevent HIV.
How Is the Trial Designed?
16Treatment groups
Experimental Treatment
Active Control
Group I: VideoExperimental Treatment1 Intervention
Group II: Training, Risk Assessment, and VideoExperimental Treatment3 Interventions
Group III: Training, Best Practice Alert, and VideoExperimental Treatment3 Interventions
Group IV: Training, Best Practice Alert, and Risk AssessmentExperimental Treatment3 Interventions
Group V: Training, Best Practice Alert, Risk Assessment, and VideoExperimental Treatment4 Interventions
Group VI: Training and VideoExperimental Treatment2 Interventions
Group VII: Training and Risk AssessmentExperimental Treatment2 Interventions
Group VIII: Training and Best Practice AlertExperimental Treatment2 Interventions
Group IX: TrainingExperimental Treatment1 Intervention
Group X: Risk Assessment and VideoExperimental Treatment2 Interventions
Group XI: Risk AssessmentExperimental Treatment1 Intervention
Group XII: Best Practice Alert, Risk Assessment and VideoExperimental Treatment3 Interventions
Group XIII: Best Practice Alert and VideoExperimental Treatment2 Interventions
Group XIV: Best Practice Alert and Risk AssessmentExperimental Treatment1 Intervention
Group XV: Best Practice AlertExperimental Treatment1 Intervention
Group XVI: No interventionActive Control1 Intervention

Find a Clinic Near You

Who Is Running the Clinical Trial?

Henry Ford Health System

Lead Sponsor

Trials
334
Recruited
2,197,000+

New York University

Collaborator

Trials
249
Recruited
229,000+

University of South Florida

Collaborator

Trials
433
Recruited
198,000+

Citations

An automated best practice advisory increases both routine ...After implementation, HIV testing increased 242%, from 2,851 tests to 9,757, and syphilis testing increased 326%, from 2,191 tests to 9,330. The proportion of ...
Effect of an Electronic Alert on Targeted HIV Testing ...The positive test result rate increased from 0.02% to 0.04% (p < 0.001). During the postimplementation period, fewer HIV-infected patients had a ...
An automated best practice advisory increases both routine ...After implementation, HIV testing increased 242%, from 2,851 tests to 9,757, and syphilis testing increased 326%, from 2,191 tests to 9,330. The proportion of ...
National HIV Prevention and Care Objectives | HIV DataIn 2022, over 80% of people with diagnosed HIV were linked to care within one month of diagnosis. Only 76% had received some care, 54% were ...
Implementing HIV prevention in the emergency departmentThis was a mixed-methods, type 3 hybrid implementation effectiveness study of seven California EDs that integrated HPS for HIV negative patients.
EHR Guide for Creating Alerts to Identify Patients Who May ...ViiV has created this guide to assist HCPs in identifying patients who may be at risk for. HIV and may be appropriate for APRETUDE (cabotegravir). Alerts ...
Designing an electronic medical record alert to identify ...We created an EMR alert using readily available data elements to identify hospitalised people with HIV (PWH) to facilitate a quality improvement study.
BEST PRACTICES IN HIV PREVENTION:These data suggest that patients with. STIs, and particularly syphilis, are prime can- didates for intensive HIV prevention efforts. However, as with HIV ...
HIV Compendium of Best PracticesThe Compendium is a searchable collection of best practices for HIV prevention designed to inform policy decisions, guidelines, program implementation, and ...
Adherence to the Continuum of Care | NIHIn addition, preliminary data from a randomized clinical trial suggest that LA CAB/RPV may be safe and effective among people without viral ...
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