CO2 Laser Treatment for Wound Margins
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial tests a CO2 laser treatment on surgical wounds to determine if it can improve the appearance of scars after skin cancer surgery. It compares laser-treated wounds to untreated ones, all following Mohs micrographic surgery. The trial seeks participants who have undergone skin cancer surgery and have wounds that can be closed with a simple stitch or flap. Participants must understand and give consent and should not have conditions like keloid scars or infections that affect healing. As an unphased trial, this study provides a unique opportunity to contribute to research that could enhance post-surgical outcomes for future patients.
Do I need to stop my current medications for the trial?
The trial does not specify if you need to stop taking your current medications, but it does exclude those who have used isotretinoin in the past 6 months.
What prior data suggests that CO2 fractionated laser treatment is safe for wound margins?
Research has shown that the CO2 fractionated laser is generally safe for treating scars and wounds. One study found that this laser treatment effectively improves the appearance of burn scars and is well-tolerated by patients. Most people experience only temporary side effects like redness or swelling. Another study demonstrated that it can aid wound healing by controlling local infections without causing serious issues. Overall, the CO2 fractionated laser appears to have minimal side effects, making it a promising option for scar treatment.12345
Why are researchers excited about this trial?
Researchers are excited about the CO2 Fractionated Laser for wound margins because it offers a new approach to enhancing wound healing. Unlike traditional treatments that might involve topical ointments or surgical techniques, the CO2 laser precisely targets and treats the wound edges, potentially promoting faster and more effective healing. This laser method could minimize scarring and improve cosmetic outcomes, which is particularly beneficial for patients concerned about visible scars. Additionally, the precision of the laser treatment may reduce the risk of infection and complications compared to more conventional methods.
What evidence suggests that CO2 fractionated laser treatment is effective for improving postoperative scar appearance?
Research has shown that CO2 fractionated lasers can enhance the appearance of scars. In this trial, one group will receive treatment with the CO2 Laser Treated Edge, while the other will have a Non-laser treated edge. Studies have found that this laser treatment can improve the appearance of both sunken and raised scars. Specifically, one study noted improvements in the thickness, smoothness, and color of scars after treatment. Another study indicated that CO2 laser therapy might accelerate wound healing and reduce the risk of infection. Overall, the fractional CO2 laser is recognized for its ability to enhance skin healing and improve scar quality.678910
Who Is on the Research Team?
Stan Tolkachjov, MD
Principal Investigator
Baylor Health Care System
Are You a Good Fit for This Trial?
This trial is for people undergoing Mohs micrographic surgery (MMS) who want to see if a special laser treatment can improve how their surgical scars look. Specific inclusion and exclusion criteria are not listed, but participants must be eligible for MMS.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Intraoperative fractionated CO₂ laser treatment of surgical wound edges during Mohs micrographic surgery
Follow-up
Participants are monitored for scar appearance and safety outcomes post-surgery
What Are the Treatments Tested in This Trial?
Interventions
- CO2 Fractionated Laser
Trial Overview
The study compares two treatments applied during surgery: one group gets a fractionated CO₂ laser on the wound edges, while the other group does not receive this laser treatment. The goal is to see which method leads to better-looking scars.
How Is the Trial Designed?
2
Treatment groups
Active Control
Find a Clinic Near You
Who Is Running the Clinical Trial?
Baylor Research Institute
Lead Sponsor
Citations
An Overview of the Mechanisms of Fractional CO2 Laser in ...
The fractional CO2 laser has demonstrated effective therapeutic results for both atrophic and hypertrophic scars. Researchers indicate that fractional CO2 laser ...
Evaluating the Safety and Efficacy of Fractionated Carbon ...
This study will evaluate the efficacy and safety of laser therapy on postoperative lower extremity wound healing over 12 weeks.
Progress in the application of ablative fractional lasers in ...
This literature review aims to explore the application of ablative fractional laser in chronic wound healing, focusing on its clinical efficacy and mechanisms ...
Ablative fractional CO2 laser for burn scar reconstruction ...
Our preliminary results confirm significant improvement in thickness, texture, colour, and symptoms following treatment with CO2-AFL. Foremost, quality of life ...
Fractional CO₂ Laser & Wound Healing (Science Explained)
Evidence supports its effectiveness in improving acne and surgical scars, correcting pigmentation irregularities, tightening ageing skin, and ...
CO2 Laser for Esthetic Healing of Injuries and Surgical ... - PMC
A number of studies have recently demonstrated the effectiveness of CO 2 laser irradiation for the repair and regeneration of scar tissue from injuries or ...
Effectiveness and safety of ablative fractional CO2 laser for ...
This study demonstrates that AFL-CO 2 is an effective and safe treatment modality for burn scars improving thickness, symptoms and quality of life of burn ...
Efficacy and safety of CO 2 laser in the treatment of chronic ...
Studies have shown that CO2 laser debridement can control local infection and promote the wound healing process. The present study aimed to ...
Efficacy and Safety of Fractional CO2 Laser Resurfacing in ...
Conclusions: Fractional photothermolysis with a fractional CO2 laser gives excellent results in patients with post-burn scars with minimal adverse effects.
Dynamic Evaluation of Microwound Healing Induced by a ...
In this study, we used a fractional CO₂ laser to create microwounds. To evaluate wound healing, creation of an ablative zone using a non- ...
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