Targeted Pediatric High-Grade Glioma Therapy
What You Need to Know Before You Apply
What is the purpose of this trial?
The goal of this study is to perform genetic sequencing on brain tumors from children, adolescents, and young adult patients who have been newly diagnosed with a high-grade glioma. This molecular profiling will decide if patients are eligible to participate in a subsequent treatment-based clinical trial based on the genetic alterations identified in their tumor.
Who Is on the Research Team?
Maryam Fouladi, MD
Principal Investigator
Nationwide Children's Hospital
Margot Lazow, MD
Principal Investigator
Nationwide Children's Hospital
Are You a Good Fit for This Trial?
Inclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Molecular Profiling
Comprehensive molecular screening of tumor tissue using a multi-omic approach to determine eligibility for treatment arms
Treatment
Patients are stratified to biologically-targeted treatment arms based on tumor molecular profile and histopathology
Follow-up
Participants are monitored for safety and effectiveness after treatment, including longitudinal evaluation of biomarkers
What Are the Treatments Tested in This Trial?
Interventions
- Targeted Pediatric High-Grade Glioma Therapy
Find a Clinic Near You
Who Is Running the Clinical Trial?
Nationwide Children's Hospital
Lead Sponsor