Fasting for Multiple Myeloma Prevention
(PROFAST Trial)
Trial Summary
What is the purpose of this trial?
This trial tests if not eating for a certain number of hours each night can help overweight and obese people with certain pre-cancerous conditions avoid developing blood cancer. The study involves a small group of people who will either follow the fasting plan or receive healthy living tips. Not eating for a set period each night is a new approach for weight loss that may have additional health benefits.
Will I have to stop taking my current medications?
The trial information does not specify whether you need to stop taking your current medications. It's best to discuss this with the trial team or your doctor.
What data supports the effectiveness of the fasting treatment for multiple myeloma prevention?
Research suggests that fasting can enhance the effectiveness of cancer treatments by reducing harmful side effects and improving treatment outcomes. Studies have shown that fasting or fasting-mimicking diets can lower levels of certain growth factors and hormones that cancer cells need to grow, potentially making treatments more effective.12345
How is the Prolonged Fasting Intervention treatment different from other treatments for multiple myeloma?
The Prolonged Fasting Intervention is unique because it uses fasting to potentially protect normal cells while targeting cancer cells, unlike traditional treatments that often involve drugs or chemotherapy. This approach is still being researched, but it may help reduce the side effects of other cancer treatments and improve their effectiveness.24567
Research Team
Catherine Marinac, PhD
Principal Investigator
Dana-Farber Cancer Institute
Eligibility Criteria
This trial is for overweight or obese adults with precursor blood cancers like MGUS, SMM, or SWM who fast less than 14 hours at night. Participants must be comfortable using a cell phone to send texts and have no active cancer treatments, diabetes without doctor's consent, night shift work, eating disorders affecting nighttime eating, or use of weight loss meds.Inclusion Criteria
Exclusion Criteria
Timeline
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants are randomized into either the PROFAST intervention group or the Healthy Lifestyle Control group for 4 months
Follow-up
Participants are monitored for changes in body composition and M-Protein levels
Treatment Details
Interventions
- EDUCATION CONTROL
- Prolonged Fasting Intervention
Find a Clinic Near You
Who Is Running the Clinical Trial?
Dana-Farber Cancer Institute
Lead Sponsor
National Cancer Institute (NCI)
Collaborator