Olive Oil for Trigeminal Neuralgia

WJ
DR
Overseen ByDaniela Rivero-Mendoza, MS
Age: 18+
Sex: Female
Trial Phase: Academic
Sponsor: University of Florida
No Placebo GroupAll trial participants will receive the active study treatment (no placebo)

What You Need to Know Before You Apply

What is the purpose of this trial?

This trial explores whether adding olive oil to the diet can reduce facial pain caused by trigeminal neuralgia type 1 (TGN), a condition that leads to severe facial pain. Participants will either include olive oil in their diet or follow standard dietary guidelines to determine if olive oil aids in pain relief. This trial suits individuals diagnosed with trigeminal neuralgia who are open to dietary changes and willing to track their food intake online. As an unphased trial, it offers a unique opportunity to contribute to innovative dietary research that could enhance pain management strategies.

Do I have to stop taking my current medications for this trial?

The trial information does not specify whether you need to stop taking your current medications. It focuses on dietary changes, specifically consuming olive oil.

Is there any evidence suggesting that this trial's treatments are likely to be safe?

Research shows that olive oil is generally safe to consume. People have incorporated it into their diets for hundreds of years. No major safety concerns arise when used in normal amounts, such as in cooking or as a salad dressing.

Olive oil is gentle on the body, with few reports of serious side effects. Some individuals might experience mild stomach discomfort if consumed in large quantities, but this is rare. The current trial involves adding 60 mL to the diet, which is a reasonable amount for most people.

Overall, olive oil is considered safe and usually easy to tolerate. Those with allergies or specific health conditions should consult a healthcare provider before making dietary changes.12345

Why are researchers excited about this trial?

Unlike standard treatments for trigeminal neuralgia, which often include medications like anticonvulsants or nerve blocks, this new approach uses olive oil as a dietary supplement. Olive oil is unique because it is a natural product with anti-inflammatory properties, which might help reduce facial pain more gently than traditional drugs. Researchers are excited about this treatment's potential for fewer side effects and its ability to integrate seamlessly into a patient's daily diet. Additionally, incorporating olive oil could offer a holistic approach to managing pain, possibly enhancing overall health and well-being.

What evidence suggests that olive oil might be an effective treatment for trigeminal neuralgia?

Research has shown that olive oil might help with various health issues, but its effect on trigeminal neuralgia (TGN) remains under study. In this trial, one group of participants will incorporate 60 mL of olive oil into their usual diet while following Dietary Guidelines recommendations. Olive oil has been linked to a lower risk of long-term illnesses like heart disease and type 2 diabetes and may also reduce the risk of dying from dementia. While these benefits are encouraging, little direct evidence exists about olive oil's impact on TGN. Current thinking is based on its overall health benefits and its ability to reduce inflammation, which might help ease facial pain. More research is needed to understand its specific effects on TGN.678910

Who Is on the Research Team?

WJ

Wendy J Dahl, PhD

Principal Investigator

University of Florida

Are You a Good Fit for This Trial?

Inclusion Criteria

Willing to complete online questionnaires associated with the study.
Able to provide written informed consent in English
Have access to the internet to complete online questionnaires
See 5 more

Exclusion Criteria

You don't meet any of the criteria mentioned above.
You are already taking part in another clinical trial.

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Treatment

Participants incorporate 60 mL of olive oil into their usual diet along with Dietary Guidelines recommendations

12 weeks
Online/distance monitoring

Follow-up

Participants are monitored for safety and effectiveness after treatment

4 weeks

What Are the Treatments Tested in This Trial?

Interventions

  • Dietary Guideline recommendations
  • Olive oil

How Is the Trial Designed?

2

Treatment groups

Experimental Treatment

Active Control

Group I: Olive OilExperimental Treatment1 Intervention
Group II: ControlActive Control1 Intervention

Find a Clinic Near You

Who Is Running the Clinical Trial?

University of Florida

Lead Sponsor

Trials
1,428
Recruited
987,000+

Citations

Health Outcomes Associated with Olive Oil Intake

Several studies suggested a negative association between olive oil (OO) consumption and the risk of several chronic diseases.

Regular extra-virgin olive oil intake independently ...

Indeed, it has been widely suggested that the consumption of a MedDiet rich in olive oil can prevent obesity (32, 33), type 2 diabetes mellitus ...

Changes in olive oil consumption and long-term body weight ...

Olive oil intake is inversely associated with risk of cardiometabolic diseases. However, its energy density has raised concerns about weight gain.

Consumption of Olive Oil and Diet Quality and Risk ...

The consumption of more than 7 g/d of olive oil was associated with a 28% lower risk of dementia-related death compared with never or rarely consuming olive ...

Effect of olive oil consumption on cardiovascular disease ...

Olive oil consumption was associated with a 22% lower relative risk of T2D (RR: 0.78; 95% CI: 0.69 to 0.87, per 25 g/d) without evidence of ...

SAFETY DATA SHEET

Handle in accordance with good industrial hygiene and safety practice. Page 4. Olive Oil. Revision Date 26-Dec-2021.

Olive oil - Material Safety Data Sheet

Eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. If irritation develops, get medical aid.

extra virgin olive oil - SAFETY DATA SHEET

Show this safety data sheet to the doctor in attendance. Eye: Contact may cause transient eye irritation In case of eye contact. Flush eyes with ...

OLIVE OIL - Safety Data Sheet

Hazardous to the aquatic environment, long–term. (chronic). : Very toxic to aquatic life with long lasting effects. Not rapidly degradable.

Safety Data Sheet Olive Oil Revision 4, Date 18 Mar 2021

Contain runoff from fire control water or dilution water - Runoff may pollute waterways. SAFETY DATA SHEET OLIVE OIL REVISION 4, DATE 18 MAR ...