Renal Denervation for Loin Pain-Hematuria Syndrome
Trial Summary
What is the purpose of this trial?
This trial tests a new treatment called radiofrequency nerve ablation for young women with severe kidney pain from LPHS. The treatment uses heat to destroy nerves that send pain signals to the brain. The goal is to see if this method can effectively reduce pain without major surgery or heavy reliance on opioids. Radiofrequency nerve ablation has been explored as a treatment for LPHS, showing promise in reducing pain and medication use.
Research Team
Bhanu Prasad, MD
Principal Investigator
Saskatchewan Health Authority - Regina Area
Eligibility Criteria
This trial is for adults over 18 with Loin Pain Hematuria Syndrome, diagnosed by a nephrologist and urologist, who are currently on prescription pain meds. Participants must have certain artery sizes and can't join if they've had kidney transplants, are pregnant/nursing, have specific kidney issues or vascular abnormalities, need chronic oxygen support, or have a history of renal procedures.Inclusion Criteria
Exclusion Criteria
Timeline
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants undergo either renal denervation or a sham procedure under general anesthesia
Follow-up
Participants are monitored for safety and effectiveness after treatment, with assessments at 6 weeks, 3 months, and 6 months
Open-label extension
Participants in the sham group may opt to receive the renal denervation procedure after the 6-month follow-up
Treatment Details
Interventions
- Symplicity Spyral™ multi electrode renal denervation system
Find a Clinic Near You
Who Is Running the Clinical Trial?
Saskatchewan Health Authority - Regina Area
Lead Sponsor
University of Saskatchewan
Collaborator