Desflurane for Surgery

Overseen By Sandra A Durbin, CLPN, CCRP

Age: 18+

Sex: Any

Trial Phase: Academic

Sponsor: The Cleveland Clinic

Disqualifiers: Operations <1.5 hours

No Placebo Group All trial participants will receive the active study treatment (no placebo)

Compensation: Varies

Number of Visits: 1

Duration: 1 day

What You Need to Know Before You Apply

What is the purpose of this trial?

This trial compares the effectiveness of Desflurane and Isoflurane as anesthesia during surgery. Researchers aim to determine if Desflurane could be a better option for surgical patients. Adults undergoing surgery requiring general anesthesia at the Cleveland Clinic may qualify, provided the surgery lasts longer than 1.5 hours. As an unphased trial, this study allows patients to contribute to valuable research that could enhance anesthesia options for future surgeries.

Do I need to stop taking my current medications for the Desflurane for Surgery trial?

The trial information does not specify whether you need to stop taking your current medications. It's best to consult with the trial coordinators or your doctor for guidance.

Is there any evidence suggesting that this trial's treatments are likely to be safe?

Research has shown that desflurane is generally safe for anesthesia. Studies from 2003 to 2020 indicate that side effects are rare, especially in brain surgery patients. One study found no safety differences between low and high amounts of desflurane during long surgeries. However, younger patients might experience more breathing issues.

Isoflurane is also safe, but excessive amounts can cause heart and breathing problems. There is concern about operating room staff being exposed to high levels of isoflurane, which could affect their health. Overall, both desflurane and isoflurane are safe when used properly, but careful monitoring is crucial to prevent problems. ^{1 2 3 4 5}

Why are researchers excited about this trial?

Researchers are excited about using desflurane and isoflurane for general anesthesia in surgery because they both offer unique benefits compared to traditional options like sevoflurane. Desflurane is distinct due to its rapid onset and recovery times, allowing patients to wake up faster after surgery. Isoflurane, on the other hand, is known for its stability and has been widely used, offering a reliable alternative. Both treatments aim to enhance safety and efficiency during surgical procedures, which is why they are being closely studied.

What evidence suggests that this trial's treatments could be effective for surgery?

This trial will compare desflurane and isoflurane for general anesthesia during surgery. Studies have shown that desflurane stabilizes vital signs and maintains good oxygen levels during surgery. It also enables faster recovery after surgery compared to some other anesthetics, with no major breathing problems reported. Isoflurane, another option in this trial, effectively supports surgery and helps maintain steady blood pressure when combined with other medications. Both anesthetics are reliable for general surgery, but desflurane may enhance recovery for some patients. ^{2 6 7 8 9}

Who Is on the Research Team?

Allen Keebler, D.O.

Principal Investigator

The Cleveland Clinic

Are You a Good Fit for This Trial?

This trial is for adults undergoing general anesthesia in the G operating room suite at the Cleveland Clinic Main Campus. It's designed to see if switching from one anesthetic (Isoflurane) to another (Desflurane) can speed up recovery and discharge.

Inclusion Criteria

I am an adult scheduled for surgery with general anesthesia at the Cleveland Clinic Main Campus.

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Treatment

Participants receive general anesthesia with either desflurane or isoflurane

1 day

1 visit (in-person)

Post-anesthesia care

Participants are monitored for recovery and emergence from anesthesia

1-2 hours

Follow-up

Participants are monitored for postoperative delirium and other outcomes

5 days

What Are the Treatments Tested in This Trial?

Interventions

• Desflurane
• Isoflurane

Trial Overview The study compares two anesthetics: Isoflurane, which is commonly used, and Desflurane, which may allow faster postanesthetic recovery. The goal is to determine if Desflurane could be a better option for speeding hospital discharge after surgery.

How Is the Trial Designed?

Group I: Isoflurane Experimental Treatment 1 Intervention

General anesthesia with isoflurane.

Group II: Desflurane Experimental Treatment 1 Intervention

General anesthesia with desflurane.

Who Is Running the Clinical Trial?

The Cleveland Clinic

Lead Sponsor

Trials

1,072

Recruited

1,377,000+

Citations

1. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov/articles/PMC3531527/

The safety and efficacy of minimal-flow desflurane anesthesia ... Conclusions. In prolonged laparoscopic surgery, no significant differences were found in safety and efficacy between minimal-flow and high-flow desflurane ...

2. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov/articles/PMC5520587/

A prospective observational study of the use of desflurane ... Desflurane anesthesia provided stable vital signs, intraoperative hemodynamics, and oxygen saturation. There were no major adverse airway events reported in ...

3. frontiersin.org frontiersin.org/journals/surgery/articles/10.3389/fsurg.2022.862632/full

Postoperative Recovery Outcomes for Obese Patients ... In conclusion, we noted desflurane was associated with better postoperative recovery outcomes than sevoflurane or propofol for obese patients.

4. brieflands.com brieflands.com/journals/aapm/articles/17449

Recovery Following Desflurane Versus Sevoflurane ... This study aims to characterize the severity and duration of cognitive impairment following sevoflurane or desfluane anesthesia after brief ...

5. sciencedirect.com sciencedirect.com/science/article/pii/S0104001421002359

Comparison of minimal-flow sevoflurane versus desflurane ... The study found no significant difference in terms of reliability between minimal-flow sevoflurane and desflurane anesthesia.

6. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov/articles/PMC12484100/

Desflurane Safety Revisited: A Pharmacovigilance Study ... A systematic review (2003–2020) suggested minimal AEs when desflurane was used for anesthesia maintenance in supratentorial brain tumor ...

7. sciencedirect.com sciencedirect.com/science/article/pii/S0952818024002058

Desflurane versus sevoflurane anesthesia and ... Postoperative recovery was not significantly faster after desflurane anesthesia. •. PONV, delirium and cognitive dysfunction were similar between the groups.

8. apsf.org apsf.org/article/pharmacovigilance-applied-to-the-use-of-sevoflurane-and-desflurane-nearly-30-years-of-adverse-event-reporting/

Pharmacovigilance Applied to the Use of Sevoflurane and ... Respiratory events were more prevalent than other adverse events in younger patients receiving desflurane. The greatest percentage of AEs in the Injury, ...

9. thelancet.com thelancet.com/journals/lanplh/article/PIIS2542-5196(24)00331-0/fulltext

Environmental & Patient Safety from Green Anesthesia Initiative A health-system wide intervention reduces greenhouse gas emissions attributable to anaesthesia care without detriment to patient outcomes.