Early Neuroimaging for Stroke Recovery
(MECHANIST Trial)
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial aims to better understand how stroke affects movement and recovery, with a focus on arm and hand movement issues. Researchers will examine brain images and conduct movement tests over time to identify early signs that predict these movement problems. Individuals who have experienced a stroke affecting specific brain areas and have movement issues, but no major speech or vision problems, might be suitable candidates. The knowledge gained could enhance predictions and treatments for stroke recovery, specifically targeting motor recovery with early imaging.
As an unphased study, this trial offers participants the chance to contribute to groundbreaking research that could improve future stroke recovery treatments.
Will I have to stop taking my current medications?
The trial information does not specify whether you need to stop taking your current medications. It's best to discuss this with the trial coordinators or your doctor.
What prior data suggests that this neuroimaging protocol is safe for stroke patients?
Research has shown that early imaging to aid movement recovery after a stroke is generally safe. Most patients improve in the weeks or months following a stroke, though many still face some challenges. Treatments focusing on movement recovery, such as specific motor tests, have been well-received by patients.
Some studies have examined the effects of starting rehabilitation soon after a stroke, but results are mixed. One review found that beginning rehab very early might increase the risk of death or severe stroke while in the hospital. However, it also suggested that early rehab could help reduce long-term disability.
Overall, the treatment in this trial emphasizes imaging and motor testing, which are generally safe. However, any early treatment might carry some risks. Patients should discuss potential benefits and risks with their healthcare provider.12345Why are researchers excited about this trial?
Researchers are excited about the Motor Recovery with Early Imaging in Stroke approach because it aims to enhance stroke recovery by using advanced imaging techniques early in the treatment process. Unlike traditional stroke treatments that primarily focus on physical rehabilitation and medication after the fact, this method uses imaging to tailor interventions specific to the patient's brain injury right away. By identifying the precise areas of damage early, doctors can optimize recovery strategies, potentially improving outcomes and speeding up recovery times. This personalized approach could represent a significant shift in how stroke recovery is managed, offering hope for more effective treatments.
What evidence suggests that early neuroimaging is effective for stroke recovery?
Research has shown that early brain scans can predict which stroke patients will regain movement. These scans identify patients likely to recover. Studies have also found that adding motor imagery (thinking about moving) to regular therapy can enhance recovery. Approximately 60% of patients can fully recover hand function within six months if they show early improvement. Starting rehabilitation soon after a stroke is crucial for better results.678910
Who Is on the Research Team?
Julius PA Dewald, PT, PhD
Principal Investigator
Northwestern University
Are You a Good Fit for This Trial?
Inclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Initial Assessment
Neuroimaging and quantitative motor testing conducted within 96 hours post-stroke
Early Follow-up
Neuroimaging and quantitative motor testing conducted 2 weeks post-stroke
Mid-term Follow-up
Neuroimaging and quantitative motor testing conducted 3 months post-stroke
Long-term Follow-up
Neuroimaging and quantitative motor testing conducted 6 months post-stroke
What Are the Treatments Tested in This Trial?
Interventions
- Motor Recovery with Early Imaging in Stroke
Find a Clinic Near You
Who Is Running the Clinical Trial?
Northwestern University
Lead Sponsor
National Institute of Neurological Disorders and Stroke (NINDS)
Collaborator
Shirley Ryan AbilityLab
Collaborator
Citations
Efficacy of motor imagery in post-stroke rehabilitation
Current evidence suggests that Motor imagery provides additional benefits to conventional physiotherapy or occupational therapy.
Neuroimaging of motor recovery after ischemic stroke
Post-stroke motor recovery can be predicted by early neuroimaging measures. Abstract. The long-term motor outcome of acute stroke patients may be correlated to ...
Motor Recovery In Stroke
Full recovery at 6 months was achieved in 60% of patients with some early finger extension. Recovery of function in the LEs. Recovery of LE ...
Rehabilitation is Initiated Early After Stroke, but Most Motor ...
The aim of this review was to determine the percentage of motor rehabilitation RCTs initiated within 30 days of stroke, and characterize these studies.
Stroke rehabilitation: from diagnosis to therapy
This paper provides a thorough exploration of rehabilitation strategies in stroke management, focusing on diagnostic methods, acute management, and diverse ...
Motor rECovery witH eArly imagiNg In STroke
The study will utilize quantitative motor testing (kinematics and kinetics) to measure motor impairment and reaching and hand function. Both ...
Imaging motor recovery after stroke - PMC - PubMed Central
Most patients show improvement in the weeks or months after a stroke. Recovery is incomplete, however, leaving most with significant impairment and disability.
Evidence of rTMS for Motor or Cognitive Stroke Recovery
This systematic review and meta-analysis of 57 articles involving 2595 subjects show that divergent rTMS techniques are safe and hold potential ...
Efficacy and safety of very early rehabilitation for acute ...
This meta-analysis proved that VER could elevate the risk of death after stroke and stroke severity during hospitalization. However, it significantly lowered ...
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neurolrespract.biomedcentral.com
neurolrespract.biomedcentral.com/articles/10.1186/s42466-020-00060-6Recovery from stroke: current concepts and future perspectives
This review provides a comprehensive survey of recent developments in the field of stroke recovery using neuroimaging and non-invasive brain stimulation.
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