Melatonin for Stress
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial tests whether melatonin, a common sleep aid, can reduce physical symptoms like heart rate and skin temperature during stress. Participants will take either a melatonin tablet or a placebo (a pill with no active ingredients) before undergoing stress tests. The trial seeks individuals who can abstain from caffeine and alcohol for a short period before the test and do not have certain sleep disorders or serious health conditions.
As an unphased trial, this study offers participants the chance to contribute to understanding how melatonin might help manage stress symptoms.
Will I have to stop taking my current medications?
If you are currently using psychoactive, hypnotic, stimulant, or analgesic medications, beta blockers, or alpha blockers, you will need to stop taking them at least a month before joining the trial. Occasional use of non-narcotic pain relievers is allowed.
Is there any evidence suggesting that melatonin is likely to be safe for humans?
Research has shown that melatonin is usually safe for use. In studies comparing melatonin to a placebo (a pill with no active ingredient), both groups reported very few side effects, indicating that melatonin users did not experience more side effects than those taking the placebo.
Melatonin is sold over-the-counter for sleep problems, suggesting it is generally safe for most people. No known dangerous reactions or conditions need to be avoided with melatonin. However, as with any supplement, following the recommended dose and consulting a healthcare provider if there are any concerns is important.12345Why are researchers excited about this trial?
Unlike the standard treatments for stress, such as cognitive-behavioral therapy and medications like SSRIs, melatonin offers a natural alternative derived from the hormone that regulates sleep. Researchers are excited about melatonin because it may address stress by improving sleep quality, which is often disrupted during stressful periods. Additionally, melatonin is non-addictive and has a well-known safety profile, making it an attractive option for those seeking a more natural approach to managing stress.
What evidence suggests that melatonin might be an effective treatment for stress?
Research has shown that melatonin can reduce oxidative stress, a harmful process linked to stress. Studies suggest that melatonin may help the body manage stress by protecting brain areas affected by it and reducing related damage. In animal studies, melatonin improved stress-related behaviors. This trial will test melatonin as an experimental treatment, with participants ingesting a 3mg melatonin tablet before stress reactivity assessment. Known for regulating sleep, this treatment may also aid in managing stress. Although more human research is needed, these findings suggest melatonin might help manage stress responses.678910
Are You a Good Fit for This Trial?
This trial is for individuals who experience stress and are interested in how melatonin might affect their body's response to it. Specific eligibility criteria details were not provided, so general health status and other factors would need to be confirmed with the study organizers.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants receive either melatonin or placebo prior to stress reactivity assessment
Follow-up
Participants are monitored for cardiovascular and skin temperature responses to stress
What Are the Treatments Tested in This Trial?
Interventions
- Melatonin
Trial Overview
The study is testing if taking a 3 MG Melatonin tablet before a stressful event can change how the heart works and skin temperature compared to a placebo (a pill without active ingredients).
How Is the Trial Designed?
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Treatment groups
Experimental Treatment
Placebo Group
Participants will ingest an acute oral melatonin tablet (3mg) prior to stress reactivity assessment.
Participants will ingest a placebo pill of the same color and shape as the melatonin tablet prior to reactivity assessment.
Find a Clinic Near You
Who Is Running the Clinical Trial?
Baylor University
Lead Sponsor
Citations
Melatonin effectiveness in amelioration of oxidative stress ...
Conclusion: Results of the current meta-analysis showed that melatonin supplementation had a significant impact on attenuating of oxidative stress and enhancing ...
Comprehensive review of melatonin as a promising ...
This review discusses the major biological activities of melatonin, its metabolites as nutritional supplements, and its bioavailability in food sources.
Melatonin-related dysfunction in chronic restraint stress ...
The study explored the melatonin-related mechanisms of stress-associated sleep disorders on a mouse model of chronic stress.
Melatonin alleviates chronic stress-induced hippocampal ...
Melatonin improves chronic stress-induced hippocampal damage and depression-like behaviors, but the mechanism needs further study.
Melatonin and DNA Integrity: The Impact of Exogenous ...
MLT (N-acetyl-5-methoxytryptamine) has emerged as a compound of significant interest in mitigating exercise-induced oxidative stress and its consequences.
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innophos.com/-/media/innophos-com/customer-center-files/nutrition/public/unique/002/melatonin-sds.pdfSAFETY DATA SHEET Melatonin
Possibility of hazardous reactions No potentially hazardous reactions known. Conditions to avoid There are no known conditions that are likely ...
Current Insights into the Risks of Using Melatonin as a ...
In the analysis of safety data from randomized, placebo-controlled trials, minimal adverse effects were reported with both melatonin and placebo ...
Melatonin SDS, 73-31-4 Safety Data Sheets
Avoid dust formation. Avoid breathing mist, gas or vapours.Avoid contacting with skin and eye. Use personal protective equipment.Wear chemical impermeable ...
Melatonin
The (M)SDS is a Hazard Communication tool and should be used to assist in the Risk Assessment. Many factors determine whether the reported Hazards are Risks in ...
Melatonin
Long-term exposure to the product is not thought to produce chronic effects adverse to the health (as classified by EC Directives using animal ...
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