29 Participants Needed

Acceptance and Commitment Therapy for PTSD and Alcohol Use Disorder

(ACT-SHARE Trial)

HG
Overseen ByHannah Grigorian, PhD
Age: 18+
Sex: Any
Trial Phase: Academic
Sponsor: VA Office of Research and Development
No Placebo GroupAll trial participants will receive the active study treatment (no placebo)

Trial Summary

Will I have to stop taking my current medications?

The trial information does not specify whether you need to stop taking your current medications. It is best to discuss this with the trial coordinators or your healthcare provider.

What data supports the effectiveness of the treatment ACT-SHARE for PTSD and Alcohol Use Disorder?

Research shows that Acceptance and Commitment Therapy (ACT) can help reduce PTSD symptoms and alcohol use in veterans, with improvements in quality of life and fewer depressive symptoms. ACT has also been shown to enhance treatment outcomes for alcohol use disorder when combined with usual care, leading to better drinking and mental health outcomes.12345

Is Acceptance and Commitment Therapy (ACT) safe for treating PTSD and Alcohol Use Disorder?

ACT has been studied in various conditions, including PTSD and alcohol use disorder, and is generally considered safe. In studies, participants have shown improvements in symptoms and quality of life, with high retention rates, indicating that people tend to stick with the treatment without major safety concerns.13678

How does the treatment ACT-SHARE differ from other treatments for PTSD and Alcohol Use Disorder?

ACT-SHARE is unique because it combines mindfulness and acceptance strategies to help patients with PTSD and Alcohol Use Disorder, focusing on reducing avoidance and increasing psychological flexibility. Unlike traditional therapies, it emphasizes values-based behavior and frequent mindfulness practice, which may lead to sustained improvements in symptoms and quality of life.137910

What is the purpose of this trial?

Veterans seeking to improve their romantic relationships when high conflict and unhealthy dynamics (e.g., aggression) are present remain underserved within the VHA with few treatment options. Veterans with PTSD and alcohol misuse face compounding and overlapping barriers to intimate relationship functioning warranting tailored interventions. These Veterans may be best served through individual, Acceptance and Commitment Therapy (ACT) interventions which can both 1) improve the ability to manage challenging, internal experiences (e.g., physiological reactivity, cravings, beliefs about worth and trust) and 2) encourage participation in valued actions to improve relationship functioning. Following development and refinement, this clinical trial will pilot an evidence-based, integrated ACT intervention (ACT for Social Health, Achievement, and Relationship Effectiveness \[ACT-SHARE\]) to improve relationship health and safety for Veterans with PTSD alcohol misuse.

Research Team

HG

Hannah Grigorian, PhD

Principal Investigator

VA Bedford HealthCare System, Bedford, MA

Eligibility Criteria

This trial is for Veterans over 18 with PTSD and alcohol misuse who have experienced intimate partner violence (IPV) recently. They should want to improve their romantic relationships, be able to give informed consent, and agree to audio recordings. It's not for those needing inpatient care for suicidality, detoxification from severe substance use, or those with cognitive impairments or active psychosis/mania.

Inclusion Criteria

Endorses at least one act of IPV in the past 3 months
I am over 18 years old.
Consents to partner outreach if in a relationship
See 4 more

Exclusion Criteria

I do not have any cognitive issues that would prevent me from participating in the study.
Severity of active substance use requiring detoxification
Evidence of active psychosis or mania
See 1 more

Timeline

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Intervention Development

Development and refinement of the ACT-SHARE intervention through iterative feedback

Varies

Treatment

Participants receive the ACT-SHARE intervention, which includes Acceptance and Commitment Therapy tailored for social health, achievement, and relationship effectiveness

12 weeks
Weekly sessions

Follow-up

Participants are monitored for changes in relationship functioning, IPV use, PTSD symptoms, and alcohol use

12 months
3-month and 6-month follow-up assessments

Treatment Details

Interventions

  • ACT-SHARE
Trial Overview The trial tests ACT-SHARE therapy designed to help Veterans manage PTSD and alcohol misuse while improving relationship health. The therapy aims at handling internal challenges like reactivity and cravings while promoting actions that enhance intimate relationships.
Participant Groups
1Treatment groups
Experimental Treatment
Group I: ACT-SHAREExperimental Treatment1 Intervention
This is a single-arm intervention with all participants assigned to receive Acceptance and Commitment Therapy for Social Health, Achievement, and Relationship Effectiveness (ACT-SHARE). ACT-SHARE has been adapted for this study from existing interventions using Acceptance and Commitment Therapy (ACT) to address alcohol use, PTSD, social functioning, and IPV use.

Find a Clinic Near You

Who Is Running the Clinical Trial?

VA Office of Research and Development

Lead Sponsor

Trials
1,691
Recruited
3,759,000+

Findings from Research

In a pilot study involving 43 veterans with PTSD and alcohol use disorder, Acceptance and Commitment Therapy (ACT) led to significant reductions in PTSD symptoms and alcohol-related issues, with 67% of participants completing the treatment protocol.
Improvements in quality of life and reductions in depressive symptoms were also observed, suggesting that ACT is a promising treatment option for individuals with co-occurring PTSD and AUD, particularly when mindfulness practices are emphasized.
Acceptance and Commitment Therapy for Co-Occurring Posttraumatic Stress Disorder and Alcohol Use Disorders in Veterans: Pilot Treatment Outcomes.Meyer, EC., Walser, R., Hermann, B., et al.[2019]
Acceptance and Commitment Therapy (ACT) significantly improved cumulative abstinence duration and reduced depression and anxiety symptoms in patients with alcohol use disorder (AUD) and comorbid affective disorders compared to treatment as usual (TAU) alone, based on a study of 52 participants.
The benefits of ACT were sustained over a 6-month follow-up period, indicating its effectiveness as an adjunct to standard treatment for enhancing recovery outcomes in this patient population.
Acceptance and Commitment Therapy in the Treatment of Alcohol Use Disorder and Comorbid Affective Disorder: A Pilot Matched Control Trial.Thekiso, TB., Murphy, P., Milnes, J., et al.[2018]
A pilot study involving 109 participants tested a brief text message intervention based on cognitive behavioral therapy (CBT) and message framing, showing high feasibility and acceptability for individuals with co-occurring PTSD and alcohol misuse.
The CBT + Framing intervention demonstrated significant reductions in PTSD symptoms and heavy drinking episodes compared to a supportive control group, although results varied across different waves of the study, indicating the need for further research on effective interventions.
A pilot study on the feasibility, acceptability, and preliminary efficacy of a brief text message intervention for co-occurring alcohol misuse and PTSD symptoms in a community sample.Bedard-Gilligan, MA., Dworkin, ER., Kaysen, D., et al.[2022]

References

Acceptance and Commitment Therapy for Co-Occurring Posttraumatic Stress Disorder and Alcohol Use Disorders in Veterans: Pilot Treatment Outcomes. [2019]
A controlled examination of two coping skills for daily alcohol use and PTSD symptom severity among dually diagnosed individuals. [2018]
Acceptance and Commitment Therapy in the Treatment of Alcohol Use Disorder and Comorbid Affective Disorder: A Pilot Matched Control Trial. [2018]
A pilot study on the feasibility, acceptability, and preliminary efficacy of a brief text message intervention for co-occurring alcohol misuse and PTSD symptoms in a community sample. [2022]
Posttraumatic stress and substance use among military veterans: Associations with distress intolerance and anxiety sensitivity. [2022]
Using acceptance and commitment therapy techniques to enhance treatment engagement in veterans with posttraumatic stress disorder. [2021]
Evaluating transdiagnostic treatment for distress and impairment in veterans: a multi-site randomized controlled trial of Acceptance and Commitment Therapy. [2013]
Acceptance and commitment therapy in the treatment of anxiety: a systematic review. [2018]
Randomized controlled trial of cognitive behaviour therapy for comorbid post-traumatic stress disorder and alcohol use disorders. [2019]
10.United Statespubmed.ncbi.nlm.nih.gov
Efficacy of Integrated Exposure Therapy vs Integrated Coping Skills Therapy for Comorbid Posttraumatic Stress Disorder and Alcohol Use Disorder: A Randomized Clinical Trial. [2021]
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