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Behavioral Intervention

Guilt Reduction vs Exposure Therapy for PTSD (PORT Trial)

Waitlist Available
Led By Shannon Kehle-Forbes, PhD
Research Sponsored by Veterans Medical Research Foundation
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Screening 3 weeks
Treatment Varies
Follow Up baseline and 8-, 16-, and 28 weeks after the first therapy session
Awards & highlights


This trial aims to compare the effectiveness of Trauma-Informed Guilt Reduction (TrIGR) Therapy and Prolonged Exposure Therapy in veterans with PTSD and trauma-related guilt. It wants to

Who is the study for?
This trial is for veterans with PTSD who feel guilt or shame related to their trauma. Participants must be diagnosed with PTSD and have experienced a traumatic event that causes them feelings of guilt.Check my eligibility
What is being tested?
The study compares Trauma-Informed Guilt Reduction (TrIGR) Therapy with Prolonged Exposure (PE) Therapy to see which is better at reducing PTSD symptoms, improving overall functioning, and lessening feelings of guilt and shame.See study design
What are the potential side effects?
While the therapies being tested are not drugs, they may cause emotional discomfort due to recalling traumatic events. Some participants might experience increased anxiety or sadness during treatment.


Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~baseline and 8-, 16-, and 28 weeks after the first therapy session
This trial's timeline: 3 weeks for screening, Varies for treatment, and baseline and 8-, 16-, and 28 weeks after the first therapy session for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Clinician Administered PTSD Scale for DSM-5 (CAPS-5)
Secondary outcome measures
Brief Psychosocial Functioning Inventory (B-IPF)
Patient Health Questionnaire-9 (PHQ-9)
Trauma Related Guilt Inventory Cognitions Scale (TRGI)
+1 more

Trial Design

2Treatment groups
Experimental Treatment
Active Control
Group I: trauma Informed Guilt Reduction TherapyExperimental Treatment1 Intervention
6 session behavioral intervention focused on trauma-related guilt, shame, and moral injury
Group II: Prolonged Exposure TherapyActive Control1 Intervention
12 session behavioral intervention focused on PTSD symptoms

Find a Location

Who is running the clinical trial?

University of MinnesotaOTHER
1,395 Previous Clinical Trials
1,553,167 Total Patients Enrolled
Veterans Medical Research FoundationLead Sponsor
43 Previous Clinical Trials
4,776 Total Patients Enrolled
Center for Veterans Research and EducationOTHER
12 Previous Clinical Trials
1,492 Total Patients Enrolled
~105 spots leftby Jul 2027