440 Participants Needed

Biomarker Identification for Oropharyngeal Cancer

CT
Overseen ByClinical Trials Referral Office
No Placebo GroupAll trial participants will receive the active study treatment (no placebo)

What You Need to Know Before You Apply

What is the purpose of this trial?

This trial aims to find a specific biomarker (a biological indicator) for a type of throat cancer linked to the human papillomavirus (HPV). Researchers seek to identify this marker in individuals with HPV-related oropharyngeal cancer and confirm its absence in those without the cancer. Participants provide blood and saliva samples, complete questionnaires, and share medical records to support the study. Ideal participants have consented to provide samples and have a clinical suspicion or diagnosis of head and neck cancer, salivary, or thyroid neoplasm.

As an unphased trial, this study offers participants the chance to contribute to groundbreaking research that could lead to earlier detection and improved treatment options for HPV-related throat cancer.

Do I have to stop taking my current medications for the trial?

The trial information does not specify whether you need to stop taking your current medications. It is best to discuss this with the trial coordinators or your doctor.

Why are researchers excited about this trial?

Researchers are excited about this trial because it focuses on finding biomarkers for oropharynx conditions through non-invasive methods. Unlike traditional treatments that primarily involve surgery, radiation, or chemotherapy, this approach involves collecting blood and saliva samples, reviewing medical records, and completing questionnaires. The unique aspect of this method is its potential to identify specific biomarkers that could lead to earlier detection and more personalized treatment options, which might improve patient outcomes and reduce side effects compared to current treatment methods.

Who Is on the Research Team?

KM

Kathryn M. Van Abel, MD

Principal Investigator

Mayo Clinic in Rochester

Are You a Good Fit for This Trial?

Inclusion Criteria

I can sign the consent form myself.
My biopsy will be tested for p16.
My tumor is considered p16 negative.
See 6 more

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Observational

Patients undergo blood sample collection, saliva sample collection, complete questionnaires and have their medical records reviewed

Up to 24 months

Follow-up

Participants are monitored for safety and effectiveness after treatment

4 weeks

What Are the Treatments Tested in This Trial?

Interventions

  • Non-Interventional Study

How Is the Trial Designed?

1

Treatment groups

Experimental Treatment

Group I: ObservationalExperimental Treatment1 Intervention

Find a Clinic Near You

Who Is Running the Clinical Trial?

Mayo Clinic

Lead Sponsor

Trials
3,427
Recruited
3,221,000+