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Behavioural Intervention

BCI-Controlled Devices for Motor Disorders

N/A
Recruiting
Led By Jose del R. Millan, PhD
Research Sponsored by University of Texas at Austin
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up immediately after each intervention session and one-day after all sessions
Awards & highlights

Study Summary

This trial is testing whether or not a brain-computer interface (BCI) can help people with low spatial resolution differentiate patterns of activity associated with different hand movements of the same limb.

Who is the study for?
This trial is for people with certain motor disabilities (like stroke, spinal cord injury, or muscular diseases) and healthy individuals with normal vision. Participants must understand English and be able to consent. Those with serious illnesses, attention/cognitive issues preventing focus during sessions, heavy central nervous system medication, or conditions affecting EEG/EMG data collection can't join.Check my eligibility
What is being tested?
The study tests brain-computer interfaces (BCI) that read brain activity to control devices without movement. It focuses on whether neuromuscular electrical stimulation (NMES), when paired with motor imagery-based BCI, improves the differentiation of hand movement patterns in the same limb.See study design
What are the potential side effects?
Potential side effects are not explicitly listed but may include discomfort from EEG/EMG equipment or skin irritation from electrical stimulation devices used during the trial.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~immediately after each intervention session and up to one week after all sessions
This trial's timeline: 3 weeks for screening, Varies for treatment, and immediately after each intervention session and up to one week after all sessions for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Change in the BCI command delivery performance
Change in the focality and Strength of SMR Modulation
Secondary outcome measures
Change in focality of fMRI activation for different imagined movements
Changes in electroencephalography functional connectivity
Changes in motor-evoked potential amplitude
+3 more

Trial Design

4Treatment groups
Experimental Treatment
Active Control
Group I: TESS BCI - Standard MI TaskExperimental Treatment2 Interventions
Transcutaneous Electrical Spinal Stimulation (TESS) is applied for 20 minutes prior to BCI training sessions. Following TESS, BCI training is performed with visual feedback contingent to motor imagery as detected by a closed-loop BCI.
Group II: NMES BCI - Difficult MI TaskExperimental Treatment1 Intervention
BCI training is performed with NMES instead of Visual feedback. NMES is delivered over the flexors/extensors of the forearm contingent to the imagination of same-hand wrist and fingers flexion versus extension as detected by a closed-loop BCI.
Group III: Visual BCI - Standard MI TaskActive Control1 Intervention
Conventional BCI training is performed with visual feedback contingent to the imagination of right versus left hand movements as detected by a closed-loop BCI.
Group IV: Visual BCI - Difficult MI TaskActive Control1 Intervention
Conventional BCI training is performed with visual feedback contingent to the imagination of same-hand wrist and fingers flexion versus extension as detected by a closed-loop BCI.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Visual Feedback
2016
N/A
~420

Find a Location

Who is running the clinical trial?

University of Texas at AustinLead Sponsor
359 Previous Clinical Trials
81,653 Total Patients Enrolled
3 Trials studying Multiple Sclerosis
276 Patients Enrolled for Multiple Sclerosis
Jose del R. Millan, PhDPrincipal InvestigatorThe University of Texas at Austin
1 Previous Clinical Trials
32 Total Patients Enrolled

Media Library

Non-invasive BCI-controlled Assistive Devices (Behavioural Intervention) Clinical Trial Eligibility Overview. Trial Name: NCT05183152 — N/A
Multiple Sclerosis Research Study Groups: TESS BCI - Standard MI Task, Visual BCI - Standard MI Task, NMES BCI - Difficult MI Task, Visual BCI - Difficult MI Task
Multiple Sclerosis Clinical Trial 2023: Non-invasive BCI-controlled Assistive Devices Highlights & Side Effects. Trial Name: NCT05183152 — N/A
Non-invasive BCI-controlled Assistive Devices (Behavioural Intervention) 2023 Treatment Timeline for Medical Study. Trial Name: NCT05183152 — N/A
Multiple Sclerosis Patient Testimony for trial: Trial Name: NCT05183152 — N/A
~33 spots leftby Dec 2025