100 Participants Needed

Reishi Mushroom Extract for Sleep

MA
Overseen ByMatthew Amsden
No Placebo GroupAll trial participants will receive the active study treatment (no placebo)

What You Need to Know Before You Apply

What is the purpose of this trial?

This trial explores how a daily dose of Reishi mushroom extract (1:4 Reishi Liquid Extract) might improve sleep quality and reduce stress levels. The focus includes sleep quality, time to fall asleep, frequency of waking at night, and morning refreshment. It also examines whether this extract can boost daytime energy and decrease stress. Suitable candidates are U.S. residents who can read English and are willing to follow the trial rules. However, individuals with allergies, chronic illnesses, or those taking blood thinners should not participate. As an unphased trial, this study offers a unique opportunity to contribute to groundbreaking research on natural sleep aids and stress relief.

Do I need to stop taking my current medications for the trial?

The trial information does not specify if you need to stop taking your current medications. However, if you are on anticoagulants (blood thinners), you cannot participate in the trial.

Is there any evidence suggesting that Reishi mushroom extract is likely to be safe for humans?

Studies have shown that taking Reishi mushroom extract orally is likely safe for up to one year. However, some individuals might experience side effects such as nausea, dizziness, insomnia, and dry mouth. In certain cases, reports have indicated liver problems and persistent diarrhea.

Research also suggests that Reishi mushrooms may alleviate stress and sleep issues, potentially enhancing sleep quality. Despite these benefits, awareness of possible side effects remains important. Prospective trial participants should monitor their body's reactions to Reishi mushroom extract.12345

Why are researchers excited about this trial?

Unlike the standard sleep aids, which often include medications like melatonin supplements or prescription drugs, the Reishi Mushroom Extract offers a natural alternative derived from a medicinal mushroom. Researchers are excited about this treatment because it utilizes a unique active ingredient, the Reishi mushroom, which is known for its calming and immune-boosting properties. Additionally, the liquid extract form allows for rapid absorption, potentially offering quicker onset of effects compared to traditional pill forms. This novel approach not only targets sleep improvement but may also support overall wellness, making it an intriguing option for those seeking a natural remedy.

What evidence suggests that Reishi mushroom extract might be an effective treatment for sleep?

Research has shown that Reishi mushroom extract might improve sleep quality. In some animal studies, the extract helped animals fall asleep faster and sleep longer. One study found that it improved sleep in people with chronic insomnia by helping them fall asleep quicker and sleep longer. This trial will evaluate the effects of a 1:4 Reishi Liquid Extract on sleep, with participants acting as their own control. Although more research on humans is needed, these early results are promising for improving sleep and reducing stress.678910

Are You a Good Fit for This Trial?

This trial is for US residents who can read and understand English, are willing to follow the study protocol, and do not have chronic illnesses, allergies, mental health disorders, liver disease or are on anticoagulants. Pregnant/nursing women and children/adolescents are also excluded.

Inclusion Criteria

US resident
Willing and able to follow the requirements of the protocol
Can read and understand English

Exclusion Criteria

Immunocompromised individuals
Individuals with chronic illnesses
Individuals with allergies
See 5 more

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

1 week

Treatment

Participants take 1ml of Reishi mushroom extract daily, 30 mins before bed

6-7 weeks
Remote monitoring

Follow-up

Participants are monitored for changes in perceived stress and sleep disturbance levels

4-5 weeks

What Are the Treatments Tested in This Trial?

Interventions

  • 1:4 Reishi Liquid Extract

Trial Overview

The trial studies the effects of a Reishi mushroom extract taken before bed on sleep quality (duration, onset latency, nighttime awakenings) and stress levels. It aims to see if it improves restfulness and daytime energy.

How Is the Trial Designed?

1

Treatment groups

Experimental Treatment

Group I: Single arm where participants act as their own controlExperimental Treatment1 Intervention

Find a Clinic Near You

Who Is Running the Clinical Trial?

Efforia, Inc

Lead Sponsor

Trials
3
Recruited
1,200+

Citations

The anti-fatigue and sleep-aiding effects vary significantly ...

This study aims to delve into the anti-fatigue and sleep-aiding effects of various formulations containing Ganoderma lucidum extracts.

Exploration of the anti-insomnia mechanism of Ganoderma by ...

In animal studies, Ganoderma extract reduced sleep latency and prolonged sleep duration, which might be related to tumour necrosis factor (TNF) ...

Ganoderma lucidum spore extract improves sleep ...

Results: Treatment with 720 mg/kg RGLS for 14 days significantly improved the reduction of total sleep time, rapid eye movement (REM) sleep time, and non-REM ...

Extract of Ganoderma lucidum prolongs sleep time in rats

The present study showed that 3 days of GLE administration (80 mg/kg, ig) significantly prolonged total sleep time and NREM sleep time without influencing SWS ...

Mushrooms for Sleep: The 2025 Science-Backed Guide to ...

The Wang & Wang study (2022) demonstrated significant improvements in 60 chronic insomnia patients, showing reduced sleep onset time and ...

Symptom improvements and adverse effects with Reishi ...

If they answered yes, a list of AEs was then presented: poor appetite, dizziness, insomnia, dry month, headache, constipation, facial flushing, ...

Reishi - Special Subjects - Merck Manual Professional ...

Nausea, insomnia, liver toxicity, anorexia, and chronic diarrhea have been reported. Although safety of long-term use has been reported, there is no information ...

Reishi Mushroom: MedlinePlus Supplements

Are there safety concerns? Reishi mushroom extract is POSSIBLY SAFE when taken by mouth appropriately for up to one year. Reishi mushroom is ...

Ganoderma lucidum (Lingzhi or Reishi) - NCBI - NIH

lucidum acts to replenish Qi, ease the mind, and relieve cough and asthma, and it is recommended for dizziness, insomnia, palpitation, and shortness of breath.

What are the Benefits and Risks of Reishi Mushrooms?

According to some previous studies, using reishi mushrooms can improve issues such as stress and insomnia. Additionally, reishi mushrooms offer ...