L-arginine for Human Performance
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial aims to determine if L-arginine, an amino acid supplement, can enhance performance in short bursts of intense exercise. Participants will perform activities such as grip strength tests, vertical jumps, and a cycling test after taking either L-arginine or a placebo (a harmless substance resembling the supplement). The trial seeks young, healthy adults who exercise regularly, at least three times a week for the past month. Non-smokers without major health issues and not on medication may be suitable candidates. As an unphased trial, this study offers a unique opportunity to contribute to the scientific understanding of supplements and exercise performance.
Will I have to stop taking my current medications?
Yes, you cannot participate in the trial if you are taking medication for any condition.
Is there any evidence suggesting that L-arginine is likely to be safe for humans?
Research has shown that L-arginine is generally safe for use. Studies have found it can improve blood flow and lower blood pressure. However, some individuals might experience mild side effects such as nausea, stomach pain, or diarrhea. These side effects are usually not serious, and most people tolerate them well. Overall, L-arginine is considered safe for oral consumption and has been linked to enhanced exercise performance without causing serious issues.12345
Why are researchers excited about this trial?
L-arginine is unique because it is a naturally occurring amino acid that may enhance human performance by boosting nitric oxide production in the body. Unlike traditional supplements or treatments that often focus on energy or muscle mass, L-arginine's potential lies in its ability to improve blood flow and oxygen delivery to muscles during anaerobic exercises. Researchers are excited about this treatment because it could offer a safe, simple, and natural way to improve performance in activities like grip strength, vertical jumps, and cycling, without the need for synthetic performance enhancers.
What evidence suggests that L-arginine might enhance anaerobic exercise performance?
Research has shown that L-arginine can improve exercise performance. Some studies suggest it benefits endurance activities by increasing nitric oxide, which enhances blood flow and reduces fatigue. However, less evidence exists regarding its effects on short, intense activities like those in this trial. Participants will receive either L-arginine or a placebo before completing anaerobic exercise tasks. The treatment is expected to enhance performance based on its mechanism of action in the body.34678
Are You a Good Fit for This Trial?
This trial is for young adults aged 18-39 who are healthy and moderately active, exercising at least an hour a day, three days a week for the past month. Smokers or those with heart, metabolic, nerve diseases or mental health issues can't join. Also excluded are people on medication or allergic to L-arginine or dextrose.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants complete two exercise sessions after ingesting either a placebo or L-arginine, with a one-week wash-out period between sessions
Follow-up
Participants are monitored for safety and effectiveness after treatment
What Are the Treatments Tested in This Trial?
Interventions
- L-arginine
Find a Clinic Near You
Who Is Running the Clinical Trial?
University of Manitoba
Lead Sponsor