Ambulation for Frailty in Lung Transplant Patients
(iFRAIL Trial)
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial explores whether assisted walking (ambulation) can help lung transplant patients recover faster and improve their overall health during hospitalization. The goal is to determine if this approach can reduce hospital stays and lessen the need for rehabilitation. Eligible participants must have undergone a lung transplant and be able to walk, even with some assistance. As an unphased trial, this study allows patients to contribute to innovative research that could enhance recovery strategies for future lung transplant recipients.
Do I need to stop my current medications for this trial?
The trial information does not specify whether you need to stop taking your current medications. It's best to discuss this with the trial coordinators or your doctor.
What prior data suggests that this ambulation protocol is safe for lung transplant patients?
Research shows that early mobility, such as walking, is generally safe for lung transplant patients. Studies have found that this practice can enhance their mobility with minimal risk. Early movement often results in stronger muscles and improved overall function.
Importantly, there have been no major reports of complications from this activity. Patients typically tolerate walking well, allowing them to move safely with supervision. The goal is to aid lung transplant patients in recovering faster and more effectively.12345Why are researchers excited about this trial?
Researchers are excited about this trial because it focuses on ambulation, or walking, as a novel approach to help frail lung transplant patients improve their mobility. Unlike standard physical therapy, which typically involves exercises performed in a stationary position, this method involves patients actively walking with assistance. This approach may enhance recovery by building strength and endurance, potentially leading to better post-transplant outcomes. The trial aims to find out if this proactive, movement-based technique can make a difference in the recovery process compared to traditional methods.
What evidence suggests that ambulation is effective for improving frailty in lung transplant patients?
This trial will compare an ambulatory intervention with no intervention for lung transplant patients. Research has shown that assisted walking can reduce frailty in these patients. One study found that exercise programs made lung transplant candidates stronger and more active. Another study found that lung transplant patients who stayed active experienced better recovery outcomes. These findings suggest that walking could enhance recovery and shorten hospital stays for lung transplant patients.15678
Who Is on the Research Team?
Marie Budev, DO
Principal Investigator
The Cleveland Clinic
Are You a Good Fit for This Trial?
This trial is for adults on the lung transplant waiting list who can walk with or without help and are not bed/wheelchair-bound. They must understand the study, speak English, be admitted to a specific hospital floor post-ICU, and have a certain score on a frailty scale. It's not for those under 18, in urgent work-up for transplant, already hospitalized before transplant day, needing mechanical breathing support or multi-organ transplants.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Pre-Transplant Assessment
Evaluation of frailty and physical performance before lung transplant
Post-Transplant Treatment
Ambulator-assisted physical activity intervention and standard physical therapy
Follow-up
Participants are monitored for safety, effectiveness, and frailty changes after treatment
What Are the Treatments Tested in This Trial?
Interventions
- Ambulation
Find a Clinic Near You
Who Is Running the Clinical Trial?
The Cleveland Clinic
Lead Sponsor