Synovial Fluid Withdrawal or PRP Injection for ACL Tear
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial explores how two different treatments can reduce knee swelling after an ACL tear. Participants will either have fluid withdrawn from their knee, receive an injection of platelet-rich plasma (PRP) from their blood, or undergo both treatments. The goal is to determine which method best aids swelling and recovery. Ideal candidates for this trial have a recent ACL rupture, noticeable swelling, and are scheduled for ACL reconstruction surgery. As an unphased trial, this study offers a unique opportunity to contribute to medical knowledge and potentially benefit from innovative treatments.
Do I need to stop my current medications for this trial?
The trial information does not specify whether you need to stop taking your current medications. It's best to discuss this with the trial coordinators or your doctor.
Is there any evidence suggesting that this trial's treatments are likely to be safe?
Research has shown that Platelet-Rich Plasma (PRP) is generally safe for use in the knee. In past studies, patients who received PRP after ACL (anterior cruciate ligament) surgery experienced better knee function and less pain in the short to medium term. Most people tolerate PRP well. Additionally, PRP has been used in other treatments without major safety issues, which increases trust in its use. These studies have reported no major serious side effects from PRP. Overall, PRP appears to be a safe choice for those considering it as part of their ACL recovery.12345
Why are researchers excited about this trial's treatments?
Researchers are excited about the use of Platelet-Rich Plasma (PRP) for ACL tears because it harnesses the body's natural healing processes. Unlike standard treatments such as physical therapy or surgery, PRP involves injecting concentrated platelets from the patient's own blood into the affected area, potentially speeding up recovery and improving tissue regeneration. Additionally, the trial compares PRP with synovial fluid withdrawal, aiming to understand its effectiveness better. This approach could offer a less invasive and more biologically harmonious alternative to traditional methods, making it an exciting area of exploration for potentially enhancing ACL tear recovery.
What evidence suggests that this trial's treatments could be effective for ACL tears?
This trial will compare the effects of synovial fluid withdrawal with the administration of platelet-rich plasma (PRP) for anterior cruciate ligament (ACL) tears. Research has shown that PRP can improve knee stability after ACL surgery. Studies have found that PRP reduces pain and enhances knee function in the short and medium term. Specifically, patients who received PRP reported significant improvements in their knee condition 12 months after surgery. However, PRP might not offer long-term benefits for knee symptoms and function. Overall, PRP could be a promising option for enhancing recovery after an ACL injury.12346
Who Is on the Research Team?
Adam Yanke, MD, PhD
Principal Investigator
Associate Professor and Surgeon
Are You a Good Fit for This Trial?
This trial is for individuals with a sudden ACL tear and possibly associated conditions like arthritis. Participants should be scheduled for surgery and able to visit the clinic beforehand. Details on specific inclusion or exclusion criteria are not provided, but typically would involve age, overall health status, and absence of conditions that might interfere with the study.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Preoperative Treatment
Participants undergo synovial fluid withdrawal and/or PRP injection at the preoperative clinic visit
Surgery
Participants undergo surgery with synovial fluid withdrawal at the time of surgery
Follow-up
Participants are monitored for safety and effectiveness after surgery
What Are the Treatments Tested in This Trial?
Interventions
- Platelet-Rich Plasma (PRP)
- Synovial Fluid Withdrawal
Trial Overview
The study is testing whether withdrawing excess knee joint fluid at different times (during surgery or before) or injecting Platelet-Rich Plasma (PRP) affects swelling after an acute ACL rupture. It's comparing these interventions to see which one helps more.
How Is the Trial Designed?
3
Treatment groups
Experimental Treatment
Active Control
Subjects randomized to ARM 2 will have 2 synovial fluid withdrawals one at the preoperative visit and one at the time of surgery. Platelet-Rich Plasma (PRP) preparation and injection will happen at the preoperative clinic visit.
Subjects randomized to Arm 3 will have 3mL withdrawal of synovial fluid at the preoperative visit and 1 synovial fluid withdrawal at the time of surgery
Subjects randomized to Arm 1 will have 2 synovial fluid withdrawals; one at the preoperative clinic visit and one at the time of surgery
Find a Clinic Near You
Who Is Running the Clinical Trial?
Rush University Medical Center
Lead Sponsor
Arthroscopy Association of North America (AANA)
Collaborator
Citations
Effects of Platelet-Rich Plasma on Clinical Outcomes After ...
PRP applied alongside ACLR could reduce postoperative pain and improve knee function in the short and medium terms but is ineffective in the long term.
Platelet-rich plasma in anterior cruciate ligament ...
Our findings provide moderate evidence that PRP can significantly enhance knee stability post-ACL reconstruction.
3.
frontiersin.org
frontiersin.org/journals/bioengineering-and-biotechnology/articles/10.3389/fbioe.2025.1625271/fullThe impact of platelet-rich plasma injection on anterior ...
The PRP group exhibited significant improvement in IKDC scores at 12 months post-operatively (mean difference: 2.09, P = 0.01, I2 = 23%), while Lysholm scores ...
NCT07185802 | Clinical Outcome of Intra Articular Injection ...
This clinical trial will evaluate the effectiveness of platelet-rich plasma (PRP) injections for patients with anterior cruciate ligament (ACL) ...
Intra-Articular Platelet-Rich Plasma Injection After Anterior ...
In this study among patients with ACLR, the addition of postoperative PRP injection did not significantly improve knee symptoms and function.
Conservative Treatment Using Platelet-Rich Plasma ...
In the present study, all 10 patients were able to return to their pre-injury levels quickly and in good condition, with good ligament repair, ...
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