Pine Cone Extract for Allergic Rhinitis
(PCE Trial)
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial explores whether an extract from pine cones can lower IgE levels, a type of antibody often elevated in allergies, in individuals with perennial rhinitis, a condition causing chronic runny noses and sneezing. Participants will receive either a capsule containing the pine cone extract or a placebo (a non-active capsule) to compare effects. Suitable candidates are adults with perennial allergic rhinitis, with or without additional seasonal allergies. As an unphased trial, this study offers participants the chance to contribute to groundbreaking research that could lead to new treatments for allergy sufferers.
Will I have to stop taking my current medications?
The trial does not specify if you need to stop taking your current medications, but you cannot participate if you are receiving subcutaneous allergen immunotherapy or monoclonal anti-IgE (omalizumab).
Is there any evidence suggesting that this trial's treatments are likely to be safe?
Research has shown that pine cone extract offers various health benefits. For example, one study found it has strong anti-HIV effects, acting against certain viruses. Another study highlighted its antibacterial and antifungal properties, which can benefit skin health.
While detailed safety information is limited, available data suggests that products with pine cone extract can be used safely with some precautions. Wearing gloves and eye protection when handling the extract is recommended to avoid prolonged contact. This precaution indicates the need for care, not that the extract is inherently dangerous.
Although specific human trial data for pine cone extract is lacking, its use in other approved products suggests a basic level of safety. However, as this trial examines its effects on perennial rhinitis in humans, any new safety information will be crucial.12345Why are researchers excited about this trial's treatment?
Pine cone extract is unique because it offers a natural alternative for managing perennial rhinitis, a condition traditionally treated with antihistamines, nasal corticosteroids, and decongestants. Unlike these standard treatments, pine cone extract is derived from a natural source and is being studied for its potential to specifically lower serum IgE levels, which are linked to allergic reactions. Researchers are excited about this treatment's potential to offer a more targeted approach with fewer side effects, making it an appealing option for individuals seeking natural remedies.
What evidence suggests that pine cone extract might be an effective treatment for perennial rhinitis?
This trial will compare the effects of pine cone extract with a placebo. Research suggests that pine cone extract, specifically a compound called PPC, might help with allergies. In mice, PPC lowered levels of IgE, a substance often elevated in people with allergies, and reduced IL-4, a protein linked to allergic reactions. Another study found that PPC can boost the immune system by promoting T cell growth, which is important for fighting infections. While these findings are promising, they primarily come from animal studies, and limited information exists on how PPC works in humans.678910
Who Is on the Research Team?
Dennis Ledford, M.D.
Principal Investigator
Division of Allergy and Immunology, USF
Are You a Good Fit for This Trial?
Inclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants receive either placebo or 32mg PPC daily for 8 weeks
Follow-up
Participants are monitored for safety and effectiveness after treatment
What Are the Treatments Tested in This Trial?
Interventions
- Pine Cone Extract
- Placebo
Find a Clinic Near You
Who Is Running the Clinical Trial?
University of South Florida
Lead Sponsor