Treatment for Rhinitis, Allergic

Phase-Based Progress Estimates
1
Effectiveness
1
Safety
Usf Asthma Allergy and Immunology Cru, Tampa, FL
Rhinitis, Allergic+3 More
Eligibility
18+
All Sexes
Eligible conditions
Select

Study Summary

This study is evaluating whether a pine cone extract can reduce total serum IgE levels in people with perennial rhinitis.

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Eligible Conditions

  • Rhinitis, Allergic
  • Perennial Allergic Rhinitis (PAR)

Treatment Effectiveness

Study Objectives

This trial is evaluating whether Treatment will improve 1 primary outcome in patients with Rhinitis, Allergic. Measurement will happen over the course of 8 weeks.

8 weeks
Primary Objective ( total serum IgE)

Trial Safety

Trial Design

2 Treatment Groups

capsule
1 of 2
placebo capsule
1 of 2
Active Control
Non-Treatment Group

This trial requires 36 total participants across 2 different treatment groups

This trial involves 2 different treatments. Treatment is the primary treatment being studied. Participants will all receive the same treatment. Some patients will receive a placebo treatment. The treatments being tested are not being studied for commercial purposes.

capsule
DietarySupplement
patinets receiveing pine cone extract tablets
placebo capsule
Other
patinets receiving placebo

Trial Logistics

Trial Timeline

Approximate Timeline
Screening: ~3 weeks
Treatment: Varies
Reporting: 8 weeks
This trial has the following approximate timeline: 3 weeks for initial screening, variable treatment timelines, and roughly 8 weeks for reporting.

Closest Location

Usf Asthma Allergy and Immunology Cru - Tampa, FL

Eligibility Criteria

This trial is for patients born any sex aged 18 and older. There are 2 eligibility criteria to participate in this trial as listed below.

Mark “yes” if the following statements are true for you:
Subjects with perennial allergic rhinitis with or without seasonal allergic rhinitis
Male or female participants must be 18 years of age or older

Patient Q&A Section

What is rhinitis, allergic?

"Rhinitis, allergic is an inflammatory disease of the nose and lining of the mouth that occurs in response to allergens like dust mite. It is often caused by allergens and has numerous symptoms. The diagnosis is confirmed by a clinical history and the symptoms.\n" - Anonymous Online Contributor

Unverified Answer

Can rhinitis, allergic be cured?

"In a recent study, findings strongly suggest that there is an innate immune response to hay-fever in susceptible subjects. This may be partially overcome by the effects of topical corticosteroids but not by the use of oral salicylates. Therefore, rhinitis, allergic, and its exacerbation can be managed effectively and efficiently." - Anonymous Online Contributor

Unverified Answer

What are the latest developments in treatment for therapeutic use?

"We suggest that the use of high dose oral glucocorticoids for a prolonged period (a greater than 6 weeks) is no longer justified in patients presenting with bronchial asthma with a significant loss of lung function, a persistent, substantial increase in frequency of exacerbations and an almost 4-fold difference in the amount of glucocorticoid required." - Anonymous Online Contributor

Unverified Answer

What are the signs of rhinitis, allergic?

"Allergic rhinitis should be seriously considered if the patient shows the following characteristics: nasal obstruction with or without sneezing; persistent wheezing, especially when lying flat with their face upward; facial edema or erythema; erythematous conjunctival plaques; and erythematous and pruritic skin lesions of the lumbosacral area and the palms and the soles." - Anonymous Online Contributor

Unverified Answer

How many people get rhinitis, allergic a year in the United States?

"around 20 million people in the Unites States will have at least one episode of rhinitis, more often than not in all people over the age of 18. The most affected groups are the pediatric, and especially the young adult population. More than 50% are diagnosed with allergic rhinitis. The American Academy of Pediatrics recommends that individuals under the age of 18 have more frequent visits with their physician than adults. This is particularly important for asthma exacerbations and exacerbations with rhinitis, which can be severe and difficult to control and that in children may complicate the development for asthma and other allergic disorders." - Anonymous Online Contributor

Unverified Answer

What causes rhinitis, allergic?

"The main cause of allergic rhinitis is unknown, although hay fever is associated with allergy to pollen. Other factors that may predispose to allergic rhinitis include infections and other environmental factors. The onset and severity of allergic rhinitis is also influenced by external factors (especially the humidity) and internal factors (e.g. genetics, hormone levels). There have also been multiple research studies associating certain allergies with specific races, but further studies are required to confirm this fact. The nasal mucus is also affected by certain environmental factors, especially air pollution." - Anonymous Online Contributor

Unverified Answer

What are common treatments for rhinitis, allergic?

"There is a wide range of treatments for allergic rhinitis, and many individuals do not respond to more pharmacological, invasive treatments. The mainstay of symptomatic therapy is topical topical steroids but there is scope for further clinical research relating pharmacological and medical treatments to patients." - Anonymous Online Contributor

Unverified Answer

What are the common side effects of treatment?

"The number of common side effects was lowest for nasal sprays and greatest for topical steroids. When discussing therapy duration, many side effects in the short term could be construed as 'acceptable' because there was no sustained side effect, the most common of which was gastrointestinal. The most common side effect after one year for nasal sprays is nasal blockage. Topical steroid application can also result in prolonged side effects, such as local skin steroid atrophy. Treatment duration was often longer than once annually, which is helpful when evaluating side effects. Overall, treatment duration was at the higher end of the range for all indications, with topical steroids and nasal spray, to be at the lowest end of the range." - Anonymous Online Contributor

Unverified Answer

Have there been other clinical trials involving treatment?

"This preliminary analysis confirms that patients treated in clinical trials have the same benefit as patients treated in the real-world setting. The key finding from this study is that patients treated in a placebo-controlled trial have substantially less pain and other medication requirements relative to those treated in a comparator trial. Given the high costs of uncontrolled trials, results of this preliminary study have strong potential to drive future clinical trials in SS and other rheumatic diseases." - Anonymous Online Contributor

Unverified Answer

How does treatment work?

"The nasal steroid nasal sprays help with the symptoms, but only temporary relief. Doctors prefer other treatments for allergies. To take care of your allergies, see your doctor about your health, and take medication to treat them." - Anonymous Online Contributor

Unverified Answer

What does treatment usually treat?

"There are two common patterns in treatment in chronic rhinitis. The first is to treat the rhinitis as it usually presents. The second is to treat it as it is most often caused. These 2 treatment rules may be a source of confusion for patients. The third choice of management may be to treat either pattern based upon the clinical impression of the treating physician. This discussion also helps to clarify the importance of choosing the best treatment for each patient as they experience their unique treatment needs and treatment consequences." - Anonymous Online Contributor

Unverified Answer

What is the latest research for rhinitis, allergic?

"We found that the literature had not evolved in response to modern clinical practice. The most efficient way to find the recent data was through a combination of Internet searches and articles from the American Thoracic Society journal." - Anonymous Online Contributor

Unverified Answer
Please Note: These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
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