Protein Beverage for Muscle Outcomes
(VIM Trial)
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial examines a special protein drink to assess its effects on muscle building. Researchers aim to compare a new, less invasive method of measuring muscle growth with traditional, more invasive techniques. Participants will consume a protein beverage mixed with safe markers (stable isotope tracers) to track changes in muscle and body protein. The trial suits individuals aged 18-35 who exercise regularly, maintain a normal body size, and can refrain from extra physical activity for two days before a session. As an unphased trial, it offers a unique opportunity to contribute to innovative research on muscle growth measurement.
Will I have to stop taking my current medications?
The trial does not specify whether you need to stop taking your current medications. However, if you are using hormonal contraceptives, you would not be eligible to participate.
What prior data suggests that this method is safe for estimating protein synthesis?
Research shows that treatments using stable isotopes, such as the Protein + Stable Isotope Tracer Beverage, are safe for humans. These isotopes do not emit radiation and are not harmful to the body. The beverage combines these tracers with protein to study muscle protein synthesis.
Other research has used this method to safely measure muscle changes. Reviewed studies do not report any serious side effects or negative reactions. Current evidence suggests the treatment is well-tolerated.12345Why are researchers excited about this trial?
Unlike traditional protein supplements that focus merely on increasing muscle mass, the new protein + stable isotope tracer beverage is unique because it allows researchers to measure muscle protein synthesis and whole-body protein synthesis in real-time. This is achieved through the inclusion of stable isotopes \[2H5\]Phenylalanine and \[1-13C\]Phenylalanine, which offer a detailed look at how effectively muscles are built and repaired. Researchers are excited about this treatment as it could lead to more precise and personalized nutrition strategies for muscle growth and recovery, potentially optimizing results far beyond current protein supplementation methods.
What evidence suggests that this beverage is effective for muscle protein synthesis?
Research shows that eating protein helps the body build muscle. Scientists use safe markers called stable isotope tracers to track protein processing, and these have shown reliable results. One study found that increasing protein intake, along with certain building blocks of protein like leucine, improved muscle building over time. In this trial, participants will consume the Protein + Stable Isotope Tracer Beverage, which could help the body use protein more effectively to support muscle growth. For those looking to build muscle, this beverage might be a promising option based on current research.35678
Who Is on the Research Team?
Daniel Moore, Ph.D
Principal Investigator
University of Toronto, Faculty of KPE
Are You a Good Fit for This Trial?
This trial is for individuals interested in participating in research related to protein metabolism. Specific eligibility criteria are not provided, so it's important to contact the study organizers for detailed inclusion and exclusion requirements.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants consume isoenergetic, isonitrogenous beverages enriched with stable isotopes to measure muscle and whole-body protein synthesis
Follow-up
Participants are monitored for safety and effectiveness after treatment
What Are the Treatments Tested in This Trial?
Interventions
- Protein + Stable Isotope Tracer Beverage
Trial Overview
The study tests a non-invasive method called IAAO (indicator amino acid oxidation) that estimates the impact of dietary protein on whole-body protein synthesis as an alternative to muscle biopsies.
How Is the Trial Designed?
1
Treatment groups
Experimental Treatment
Participants will consume 12 half-hourly (6 hours) isoenergetic, isonitrogenous beverages containing 0.9g/kg fat-free mass/day protein. Drinks will be enriched with stable isotopes \[2H5\]Phenylalanine and \[1-13C\]Phenylalanine, which will respectively allow for determination of muscle protein synthesis and whole-body protein synthesis over the subsequent 6 hours of feeding.
Find a Clinic Near You
Who Is Running the Clinical Trial?
University of Toronto
Lead Sponsor
Citations
A novel stable isotope tracer method to measure muscle ...
This new method of measuring muscle protein FBR during physiological non-steady state gives reliable results and allows simultaneous measurement of muscle ...
Understanding the effects of nutrition and post-exercise ...
In this review, we focus on the application of stable isotope tracers to elucidate the impact of protein ingestion and exercise on skeletal muscle protein ...
A validation of the application of D 2 O stable isotope tracer ...
In the present data, we further validate the use of D2O in measuring turnover in skeletal muscle (16, 18, 33, 50) by highlighting for the first time the ...
Investigating muscle protein synthesis using deuterium oxide ...
This review highlights that protein quantity, protein quality and enhancing leucine content can increase long-term muscle protein synthesis.
5.
clinicalnutritionopenscience.com
clinicalnutritionopenscience.com/article/S2667-2685(21)00012-7/fulltextUnderstanding the effects of nutrition and post-exercise ...
In this review, we focus on the application of stable isotope tracers to elucidate the impact of protein ingestion and exercise on skeletal ...
Assessing Muscle Protein Synthesis Rates In Vivo in Humans
A validation of the application of D 2 O stable isotope tracer techniques for monitoring day-to-day changes in muscle protein subfraction synthesis in humans.
Investigating muscle protein synthesis using deuterium oxide
In contrast, stable isotopes do not emit radiation and are safe ... Application of stable isotope tracers to measure muscle protein synthesis (MPS) ...
Muscle Protein Synthesis and Whole-Body ...
In this manuscript, we review the effects, advantages, disadvantages, and knowledge gaps pertaining to supplemental free-form EAA, intact protein, and protein- ...
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