Tryptophan for Protein Absorption
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial examines how well the body absorbs tryptophan, an important amino acid, from corn. Tryptophan plays a key role in protein synthesis, and understanding its absorption can improve dietary recommendations, especially as the global population grows. Participants should be in good health, aged between 60 and 90, and have a body mass index (BMI) of less than 30. This study may interest those seeking to optimize plant-based protein intake, such as from corn. As an unphased trial, it offers a unique opportunity to contribute to nutritional science and enhance dietary guidelines.
What prior data suggests that tryptophan is safe for human consumption?
Studies have shown that tryptophan, a necessary nutrient, is generally safe in moderate amounts. For example, research indicates that healthy women who took up to 5 grams per day of L-tryptophan experienced no negative effects. This suggests that the body tolerates tryptophan well when used in normal dietary amounts.
Additionally, tryptophan is already included in some dietary supplements, offering reassurance about its safety. Overall, the available evidence suggests that tryptophan is safe, especially when consumed in amounts typically found in food.12345Why are researchers excited about this trial?
Researchers are excited about using tryptophan in this trial because it explores a new way to enhance protein absorption, particularly from maize, a common dietary staple. Unlike existing protein supplements or dietary adjustments that focus broadly on increasing protein intake, this trial uses the IAAO (Indicator Amino Acid Oxidation) method to specifically measure how well tryptophan is metabolically available when maize is prepared by moist cooking. This could lead to more effective dietary strategies, especially in regions where maize is a primary food source, potentially improving nutritional outcomes without the need for additional supplements.
What evidence suggests that tryptophan is effective for protein absorption?
Research has shown that tryptophan, a vital building block for proteins in the body, is well-absorbed from white African cornmeal, with about 80% available for use. This is important because cornmeal is a key food for many people and a major protein source for vegetarians worldwide. One study found that increased dietary tryptophan can lead to better health, such as lower death rates in some patients. Consuming more tryptophan-rich foods, especially cornmeal, can help meet protein needs, essential for growth and overall health. This trial will specifically assess the metabolic availability of tryptophan in maize prepared by a moist cooking method.16789
Who Is on the Research Team?
Glenda Courtney Martin, PhD, RD
Principal Investigator
The Hospital for Sick Children
Are You a Good Fit for This Trial?
This trial is for healthy adults over the age of 60 who are interested in contributing to research on protein absorption from plant sources like cornmeal. The study focuses on understanding how well an essential amino acid, tryptophan, is absorbed by the body.Inclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants consume a controlled diet with graded intakes of tryptophan to measure its metabolic availability
Follow-up
Participants are monitored for safety and effectiveness after treatment
What Are the Treatments Tested in This Trial?
Interventions
- Tryptophan
Find a Clinic Near You
Who Is Running the Clinical Trial?
The Hospital for Sick Children
Lead Sponsor