Mango Consumption for Prediabetes

(MG3 Trial)

Age: 18 - 65

Sex: Any

Trial Phase: Academic

Sponsor: Clinical Nutrition Research Center, Illinois Institute of Technology

Must not be taking: Anti-inflammatories, Supplements

Disqualifiers: Smoking, Heart disease, Cancer, others

Compensation: Varies

Number of Visits: 6

Duration: 4 weeks

30 Participants Needed

Trial Summary

What is the purpose of this trial?

The purpose of this study is to investigate the effect of mango intake on metabolic and inflammatory responses relative to meals in individuals at risk of developing diabetes, as well as to understand how the beneficial compounds found in mangoes are absorbed and processed in the body.

Research Team

Indika Edirisinghe, PhD.

Principal Investigator

Illinois Institute of Technology

Britt Burton-Freeman, PhD.

Principal Investigator

Illinois Institute of Technology

Eligibility Criteria

This trial is for adults aged 20-60 with a BMI of 25-35, prediabetic blood sugar levels, and no major diseases. Participants must not smoke or take conflicting medications and should be able to adhere to the study's diet and visit schedule. Pregnant individuals, those on extreme diets, or with recent significant weight changes are excluded.

Inclusion Criteria

I am between 20 and 60 years old.

My BMI is between 25 and 35.

I am generally healthy without serious organ problems.

Exclusion Criteria

Have fasting blood glucose above 125 milligrams per deciliter

Smoke, vape, or use marijuana

Have blood pressure above 160/100 millimeters of Mercury

Timeline

Screening

Participants are screened for eligibility to participate in the trial

1 hour

1 visit (in-person)

Pre-Study

Participants receive detailed instructions on study procedures and preparation

30-45 minutes

1 visit (in-person)

Treatment

Participants consume mango or control beverage relative to meals over four study-day visits

4 weeks

4 visits (in-person)

Follow-up

Participants are monitored for safety and effectiveness after treatment

1 week

Treatment Details

Interventions

• Mango

Trial Overview The study examines how eating mangoes affects metabolic and inflammatory responses in people at risk for diabetes. It compares the effects of mango consumption against a control beverage to see how these foods influence health markers related to diabetes.

Participant Groups

Group I: Mango With Meal Experimental Treatment 1 Intervention

1 cup (165 grams) of mango with standardized breakfast

Group II: Mango Before Meal Experimental Treatment 1 Intervention

1 cup (165 grams) of mango before standardized breakfast

Group III: Mango After Meal Experimental Treatment 1 Intervention

1 cup (165 grams) of mango after standardized breakfast

Group IV: Control (no mango) Placebo Group 1 Intervention

Control beverage (230 grams) with standardized breakfast

Who Is Running the Clinical Trial?

Clinical Nutrition Research Center, Illinois Institute of Technology

Lead Sponsor

Trials

55

Recruited

3,000+

National Mango Board

Collaborator

Trials

7

Recruited

300+