PLDR Radiation for Pancreatic Cancer
Trial Summary
Will I have to stop taking my current medications?
The trial does not specify if you need to stop taking your current medications, but if you have had chemotherapy before joining, you must have a 2-week period without it before starting the trial.
What data supports the effectiveness of the treatment PLDR for pancreatic cancer?
Research on similar radiation treatments for pancreatic cancer, like intensity modulated radiation therapy (IMRT) and stereotactic body radiation therapy (SBRT), shows that increasing the radiation dose can improve survival and control the cancer better without causing severe side effects. This suggests that PLDR, which is a type of radiation treatment, might also be effective.12345
Is PLDR radiation generally safe for humans?
PLDR radiation therapy has been shown to reduce the risk of damage to normal tissues compared to other radiation techniques, which suggests it is generally safe for humans. Studies have demonstrated that PLDR can lower the dose received by organs at risk, such as the kidneys and small bowel, in treatments for pancreatic and prostate cancer.678910
How does the PLDR treatment for pancreatic cancer differ from other treatments?
PLDR (Pulsed Low-Dose Rate) radiation therapy is unique because it delivers radiation in smaller, more frequent doses, which may help minimize damage to healthy tissues compared to traditional radiation methods. This approach is different from standard treatments that often use higher doses in fewer sessions.1112131415
What is the purpose of this trial?
Standard chemoradiation, followed by surgery are standard treatment plan for patients suffering from pancreatic adenocarcinoma. Due to damage to the surrounding healthy tissue caused by standard radiation, this study uses a new type of radiation plan- pulsed low-dose rate (PLDR) radiation , in combination with chemotherapeutic drug, gemcitabine, given weekly along with the radiation.
Eligibility Criteria
This trial is for adults over 18 with non-metastatic pancreatic cancer not ready for immediate surgery. They may have had prior chemo, but must have a washout period before joining. Participants need to be able to perform daily activities (ECOG status 0-2) and agree to use birth control. Excluded are those with previous radiation therapy for pancreatic cancer, uncontrolled illnesses, or certain conditions like scleroderma.Inclusion Criteria
Exclusion Criteria
Timeline
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants receive pulsed low-dose-rate (PLDR) radiation and weekly gemcitabine chemotherapy
Surgery
Standard surgery to remove the cancer after consultation with a surgeon
Follow-up
Participants are monitored for safety and effectiveness after treatment
Treatment Details
Interventions
- PLDR
Find a Clinic Near You
Who Is Running the Clinical Trial?
Fox Chase Cancer Center
Lead Sponsor