Cryotherapy for Exercise-Induced Muscle Damage

AN
Overseen ByAlvaro N Gurovich, PT, PhD

What You Need to Know Before You Apply

What is the purpose of this trial?

This trial aims to explore whether cryotherapy (applying extreme cold) can reduce damage and inflammation after exercise-induced muscle injuries. The study will compare three groups: one with no treatment, one using room-temperature cold packs, and one using very cold packs. Researchers aim to determine if cryotherapy lessens muscle damage, swelling, and oxidative stress, which can worsen injuries. The trial seeks healthy, non-smoking individuals without recent serious injuries or heart problems. As an unphased trial, participants can contribute to groundbreaking research that may improve recovery methods for muscle injuries.

Will I have to stop taking my current medications?

The trial information does not specify whether you need to stop taking your current medications. However, it does mention avoiding anti-inflammatories, so you might need to stop those. Please consult with the trial coordinators for more details.

What prior data suggests that cryotherapy is safe for exercise-induced muscle damage?

Cryotherapy, which involves using cold on the body, is generally well-tolerated. Research has shown it can reduce swelling and soreness after exercise. For instance, one study found that cryotherapy lessened muscle soreness and swelling following exercise-related damage. Another study demonstrated that cold water therapy, a type of cryotherapy, accelerated recovery after exercise.

However, its effect on muscle function remains unclear. Only a small number of participants reported significant improvements in muscle performance. Thus, while cryotherapy is safe and effective for reducing swelling and soreness, it may not significantly enhance muscle performance for everyone.

Overall, cryotherapy is widely used and considered safe for most people. Consulting a healthcare provider is recommended to determine if it's suitable.12345

Why are researchers excited about this trial?

Researchers are excited about cryotherapy for exercise-induced muscle damage because it offers a new way to reduce muscle soreness and speed up recovery. Unlike traditional treatments like rest, ice packs, and anti-inflammatory medications, cryotherapy involves applying extremely cold temperatures directly to the muscles, which may help reduce inflammation more effectively. This method could potentially provide quicker relief and allow athletes to get back to their training routines faster. By directly targeting the damaged tissue with cold therapy, this approach has the potential to enhance recovery in a way that current options do not.

What evidence suggests that cryotherapy might be an effective treatment for exercise-induced muscle damage?

Research has shown that cryotherapy, which uses cold temperatures, can aid muscle recovery after exercise. In this trial, one group of participants will receive cryotherapy, involving a 15-minute cold (-5°C) cold-pack immediately after exercise-induced muscle damage and then for 4 more days every 24 hours. One study found that cryotherapy reduced muscle soreness and improved muscle and nerve coordination. Another study demonstrated that combining cold with compression lowered signs of swelling and stress in the body. Cryotherapy also helped muscles recover faster and maintain performance after exercise-induced damage. While more studies on humans are needed, these findings suggest that cryotherapy might effectively reduce soreness and speed up recovery from exercise-related muscle damage.678910

Are You a Good Fit for This Trial?

This trial is for individuals experiencing chronic surgical pain or muscle damage from exercise. Participants should be interested in testing the effects of cryotherapy—a cold treatment—on their condition. Specific eligibility details are not provided, so it's assumed that a broad range of adults could qualify.

Inclusion Criteria

My blood pressure is within the normal range.
Apparently healthy
Non-smokers (all tobacco products including e-cigarettes)

Exclusion Criteria

I have not had any bone or muscle injuries in the last 6 months.
I have a heart condition or high blood pressure.
Pregnancy

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

1 day
1 visit (in-person)

Treatment

Participants undergo exercise-induced muscle damage and receive cryotherapy or room temperature cold-pack treatment

5 days
5 visits (in-person)

Follow-up

Participants are monitored for functional assessments and biomarker analysis

7 days
1 visit (in-person)

What Are the Treatments Tested in This Trial?

Interventions

  • Cryotherapy
Trial Overview The study investigates whether applying cryotherapy after inducing muscle damage through eccentric exercise can reduce secondary tissue injury and improve recovery by lowering inflammation and oxidative stress.
How Is the Trial Designed?
3Treatment groups
Active Control
Placebo Group
Group I: Control-controlActive Control1 Intervention
Group II: CryotherapyActive Control2 Interventions
Group III: ControlPlacebo Group1 Intervention

Find a Clinic Near You

Who Is Running the Clinical Trial?

University of Texas, El Paso

Lead Sponsor

Trials
17
Recruited
3,000+

Citations

Cryotherapy Models and Timing-Sequence Recovery of ...Given that whole-body cryotherapy enhanced muscle recovery and reduced muscle-performance decrements after exercise-induced muscle damage, this method was a ...
The effects of hydrotherapy and cryotherapy on recovery from ...We found that CWT was the best for recovering biochemical markers CK, and CRYO was best for muscle soreness and neuromuscular recovery.
Effect of Cold Compression and Ice Therapy on Muscle ...Conclusions. Cold compression therapy was more effective than ice or placebo in promoting muscle recovery after plyometric exercise by enhancing ...
Effects of combining cold exposure and compression on ...Results: Cryocompression significantly accelerated muscle recovery by reducing PLFFD and inflammation markers (salivary interleukin-1 beta and ...
5.pubmed.ncbi.nlm.nih.govpubmed.ncbi.nlm.nih.gov/39294614/
The effects of hydrotherapy and cryotherapy on recovery ...We found that CWT was the best for recovering biochemical markers CK, and CRYO was best for muscle soreness and neuromuscular recovery.
Whole-Body Cryotherapy in Athletes: From Therapy to ...Whole-body cryotherapy has been demonstrated to be a preventive strategy against the deleterious effects of exercise-induced inflammation and soreness.
Impact of different doses of cold water immersion (duration ...This study synthesized findings from RCTs on the effects of various doses of cold water immersion (CWI) on recovery from acute exercise-induced ...
Isolated and Combined Effects of Cold, Heat and Hypoxia ...With regard to muscle function, only 34% reported benefits, which appears to be quite ineffective.
Cryocompression Therapy for Recovery from Eccentric ...Conclusion: Cryocompression reduced limb swelling and muscle soreness, as well as post-exercise-induced muscle damage, and NWC mitigated limb swelling, but none ...
Recovery From Exercise-Induced Muscle DamageConclusions: CWI was more effective than WBC in accelerating recovery kinetics for countermovement-jump performance at 72 h postexercise. CWI also demonstrated ...
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