Mango Consumption for Obesity

(MG2 Trial)

Overseen By Indika Edirisinghe, Ph.D

Age: 18 - 65

Sex: Any

Trial Phase: Academic

Sponsor: Clinical Nutrition Research Center, Illinois Institute of Technology

Must not be taking: Antioxidants, Anti-inflammatories, Lipid-lowering, others

Disqualifiers: Smoking, Hypertension, Diabetes, Vascular disease, Cancer, others

Compensation: Varies

Number of Visits: 4

Duration: 4 weeks

What You Need to Know Before You Apply

What is the purpose of this trial?

The trial aims to explore how regular mango consumption affects gut health, inflammation, and insulin sensitivity in overweight or obese individuals with chronic low-grade inflammation. Participants will consume either a mango-based drink (using Mangifera indica, commonly known as Tommy Atkins mango) or a similar-tasting placebo drink. The study seeks individuals with a BMI of 25 or higher who are generally healthy but show signs of inflammation and do not smoke, have mango allergies, or take certain medications. As an unphased trial, this study offers a unique opportunity to contribute to understanding the health benefits of mangoes.

Will I have to stop taking my current medications?

You may need to stop taking certain medications, especially if they could interfere with the study, like anti-inflammatory drugs or lipid-lowering medications. If you're taking dietary supplements, you might need a 30-day break from them before starting the trial.

Is there any evidence suggesting that this trial's treatments are likely to be safe?

Studies have shown that eating mangoes regularly is safe for most people, including those who are overweight or obese. One study found that freeze-dried mango did not lead to weight gain in obese individuals and even had some positive effects. Another study suggested that mangoes might help improve blood sugar levels and reduce inflammation, common issues for those who are overweight.

Research on animals has also shown promising results. For example, mangoes helped lower blood sugar and reduce body fat in mice, working as well as some medicines for reducing fat.

These findings suggest that eating mangoes is generally safe and might even offer health benefits. However, it is important to consult a healthcare provider before starting any new treatment. ^{1 2 3 4 5}

Why are researchers excited about this trial?

Unlike the standard treatments for obesity, which often involve medications or surgical interventions, this innovative approach uses mango as the active ingredient. Mango is rich in fiber and bioactive compounds, which may help in managing weight by enhancing satiety and improving metabolism. Researchers are excited about this because it offers a natural, potentially side-effect-free alternative to conventional obesity treatments, making it an attractive option for those seeking a more holistic approach to weight management.

What evidence suggests that mango consumption might be an effective treatment for obesity?

This trial will compare the effects of a mango beverage with a control beverage on health issues related to being overweight. Research has suggested that eating mangoes might help control blood sugar and reduce inflammation, common concerns for those who are overweight. While mangoes don't directly cause weight loss, they also don't lead to weight gain. The fiber in mangoes can help lower blood sugar levels, making them a potentially good choice for improving overall health. However, some studies indicate that mangoes don't significantly affect inflammation related to obesity. Overall, adding mangoes to one's diet might help manage certain health risks. ^{1 2 3 4 6}

Who Is on the Research Team?

Indika v, Ph.D

Principal Investigator

Illinois Insititute of Technology

Are You a Good Fit for This Trial?

This trial is for men and women aged 20-60 with a BMI ≥ 25 kg/m2 and chronic low-grade inflammation, but otherwise in good health. Participants should not be on medications that affect the study outcomes, such as anti-inflammatories or lipid-lowering drugs, and must not have had significant weight changes recently. Smokers or those with certain medical conditions are excluded.

Inclusion Criteria

BMI ≥ 25 kg/m2

Nonsmokers (Past smokers can be allowed if they have abstinence for minimum of 2 years

I am between 20 and 60 years old with a CRP level between >1.0 and ≤10.

Exclusion Criteria

Women who are lactating

You drink more than 4 cups of coffee or tea per day.

I am a smoker.

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

1 visit

1 visit (in-person)

Pre-study

Participants complete a 3-day food diary and receive counseling to follow a limited polyphenolic diet

7 days

Treatment

Participants consume either a mango or control beverage and attend 3 Test Day Visits for assessments

4 weeks

3 visits (in-person)

Follow-up

Participants are monitored for safety and effectiveness after treatment

4 weeks

What Are the Treatments Tested in This Trial?

Interventions

• Control
• Mango

Trial Overview The trial is examining how eating mangoes regularly affects gut bacteria, inflammation levels, and insulin sensitivity in overweight/obese individuals. It involves comparing a control group to one consuming mangoes to understand the fruit's potential anti-inflammatory benefits.

How Is the Trial Designed?

Group I: Mango beverage Experimental Treatment 1 Intervention

Mango composite served as a frozen drink

Group II: Control beverage Placebo Group 1 Intervention

Energy matched Control frozen drink

Who Is Running the Clinical Trial?

Clinical Nutrition Research Center, Illinois Institute of Technology

Lead Sponsor

Trials

55

Recruited

3,000+

Food and Drug Administration (FDA)

Collaborator

Trials

184

Recruited

1,553,000+

Citations

1. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov/articles/PMC4155986/

Mango Supplementation Improves Blood Glucose in ... Our findings indicate that regular consumption of freeze-dried mango by obese individuals does not negatively impact body weight but provides a positive effect ...

2. sciencedirect.com sciencedirect.com/science/article/pii/S093947532100541X

Effects of fresh mango consumption on cardiometabolic ... Mangos may improve certain risk factors associated with overweight and obesity including improved glycemic control and reduced inflammation.

3. clinicaltrials.gov clinicaltrials.gov/study/NCT05571800

Study Details | NCT05571800 | Effect of Mango ... The investigators hypothesize that daily consumption of one mango per day for 24 weeks will improve the indices of glycemic control, cardiovascular health, and ...

4. mango.org mango.org/wp-content/uploads/2017/10/Glucose_Lipids_Exec_Summary_Eng.pdf

Mango on Glucose and Lipid Parameters in High Fat Diet- ... The. Tommy Atkins variety of mango used in this study contains approximately 4% dietary fiber, and fiber has been shown to lower blood sugar levels in ...

5. journals.sagepub.com journals.sagepub.com/doi/10.1177/1178638817731770

Mango Supplementation Has No Effects on Inflammatory ... Our findings demonstrate that 12-week consumption of freeze-dried mango by obese individuals has no impact on obesity-related inflammation.

6. centerwatch.com centerwatch.com/clinical-trials/listings/NCT05571800/effect-of-mango-consumption-on-individuals-with-pre-diabetes

Effect of Mango Consumption on Individuals with Pre- ... This study is designed to explore the effect of mango consumption on glycemic indices, cardiovascular health, and body composition in overweight and obese ...