Mango Consumption for Obesity

(MG2 Trial)

Overseen By Indika Edirisinghe, Ph.D

Age: 18 - 65

Sex: Any

Trial Phase: Academic

Sponsor: Clinical Nutrition Research Center, Illinois Institute of Technology

Must not be taking: Antioxidants, Anti-inflammatories, Lipid-lowering, others

Disqualifiers: Smoking, Hypertension, Diabetes, Vascular disease, Cancer, others

Compensation: Varies

Number of Visits: 4

Duration: 4 weeks

60 Participants Needed

Trial Summary

What is the purpose of this trial?

The primary objective of this project is to provide new knowledge through a comprehensive set of analyses that investigate the complex interplay between regular mango intake, gut microbial structure/ function, mechanisms of inflammation and insulin sensitivity in over weight (OW)/obese (OB) human subjects with chronic low-grade inflammation.

Research Team

Indika v, Ph.D

Principal Investigator

Illinois Insititute of Technology

Eligibility Criteria

This trial is for men and women aged 20-60 with a BMI ≥ 25 kg/m2 and chronic low-grade inflammation, but otherwise in good health. Participants should not be on medications that affect the study outcomes, such as anti-inflammatories or lipid-lowering drugs, and must not have had significant weight changes recently. Smokers or those with certain medical conditions are excluded.

Inclusion Criteria

BMI ≥ 25 kg/m2

Nonsmokers (Past smokers can be allowed if they have abstinence for minimum of 2 years

I am between 20 and 60 years old with a CRP level between >1.0 and ≤10.

Exclusion Criteria

Women who are lactating

You drink more than 4 cups of coffee or tea per day.

I am a smoker.

Timeline

Screening

Participants are screened for eligibility to participate in the trial

1 visit

1 visit (in-person)

Pre-study

Participants complete a 3-day food diary and receive counseling to follow a limited polyphenolic diet

7 days

Treatment

Participants consume either a mango or control beverage and attend 3 Test Day Visits for assessments

4 weeks

3 visits (in-person)

Follow-up

Participants are monitored for safety and effectiveness after treatment

4 weeks

Treatment Details

Interventions

• Control
• Mango

Trial Overview The trial is examining how eating mangoes regularly affects gut bacteria, inflammation levels, and insulin sensitivity in overweight/obese individuals. It involves comparing a control group to one consuming mangoes to understand the fruit's potential anti-inflammatory benefits.

Participant Groups

Group I: Mango beverage Experimental Treatment 1 Intervention

Mango composite served as a frozen drink

Group II: Control beverage Placebo Group 1 Intervention

Energy matched Control frozen drink

Who Is Running the Clinical Trial?

Clinical Nutrition Research Center, Illinois Institute of Technology

Lead Sponsor

Trials

55

Recruited

3,000+

Food and Drug Administration (FDA)

Collaborator

Trials

184

Recruited

1,553,000+